DataExpo GAKG DeepReport Navigation

Copyright©2015-2024 Acemap, Inc. Shanghai Jiao Tong University. All rights reserved.

沪ICP备18028330号

LK

Liping Kang

Chinese Academy of Medical Sciences & Peking Union Medical College

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Baiping Ma

Beijing Radiation Center

Zong‐Huai Liu

Shaanxi Normal University

Heshui Yu

Tianjin University of Traditional Chinese Medicine

Yang Zhao

Nanjing University of Chinese Medicine

Lanping Guo

Chinese Academy of Medical Sciences & Peking Union Medical College

Luqi Huang

Chinese Academy of Medical Sciences & Peking Union Medical College

Zhibin Lei

Shaanxi Normal University

Tiegui Nan

Chinese Academy of Medical Sciences & Peking Union Medical College

Cheng‐Qi Xiong

Beijing Radiation Center

Zhi-Lai Zhan

Chinese Academy of Medical Sciences & Peking Union Medical College

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

China Academy of Chinese Medical Sciences

University of Chinese Academy of Sciences

Sun Yat-sen University

Shanghai Jiao Tong University

Ministry of Agriculture and Rural Affairs

Shaanxi Normal University

Peking University

Sichuan University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Identification of cell-type-specific genes associated with autism by integrating gene expression and alternative polyadenylation profiles

2021 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) (2024)

Xingyu Bi Liping Kang Xiaohui Wu

Identification

Cell type

10.1109/bibm62325.2024.10821945

Cite

Citations (0)

[Rapid detection of zearalenone in Coicis Semen based on ELISA].

Yunxiang Liu Peng-Chao Gao Zhi-Lai Zhan Liping Kang Tiegui Nan

Zearalenone(ZEN) is a toxic metabolite produced by Fusarium culmorum, F. graminearum, F. tricinctum, and other fungi, with estrogenic characteristics. Exposure to or ingestion of ZEN during pregnancy can cause reproductive dysfunction, miscarriage, stillbirth, and malformation, and seriously endanger human life and health. The detection methods for ZEN in the Chinese Pharmacopoeia(2020 edition) are liquid chromatography(LC) and liquid chromatography-mass spectrometry(LC-MS), and it is stipulated that ZEN should not exceed 500 μg in 1 000 g of Coicis Semen. Although these detection methods by instruments can achieve the qualitative and quantitative analysis of ZEN in Coicis Semen, their high detection cost and long periods hinder the rapid screening of a large number of samples in the field. In this study, the synthesized ZEN hapten was conjugated with bovine serum albumin(BSA) and ovalbumin(OVA) to obtain the complete ZEN antigen. By virtue of antibody preparation techniques, ZEN monoclonal antibody 4F6 was prepared, which showed 177.5%, 137.1%, and 109.7% cross-reactivity with ZEN structural analogs zearalanol, zearalenone, and α-zearalenol, respectively, and no cross-reactivity with other fungal toxins such as aflatoxin. Direct competitive enzyme-linked immunosorbent assay(dcELISA) based on ZEN monoclonal antibody 4F6 was developed for the determination of ZEN in Coicis Semen with an IC_(50) of 1.3 μg·L~(-1) and a detection range of 0.22-21.92 μg·L~(-1). The recoveries were 83.91%-105.3% and the RSD was 4.4%-8.0%. The established dcELISA method was used to determine the ZEN residuals in nine batches of Coicis Semen samples, and the results were validated by LC-MS. The correlation between the two detection methods was found to be 0.993 9, indicating that the established dcELISA could be used for the rapid qualitative and quantitative detection of ZEN residuals in Coicis Semen.

10.19540/j.cnki.cjcmm.20221211.101

Cite

Citations (0)

Clinical significance of baseline Epstein–Barr virus DNA for recurrent or metastatic primary pulmonary lymphoepithelioma-like carcinoma

Future Oncology (2023)

Qihua Zou Kongjia Luo Liping Kang Caiwen Huang Jianliang Mai

Background: This study aimed to evaluate the clinical significance of baseline Epstein-Barr virus (EBV) DNA in recurrent or metastatic primary pulmonary lymphoepithelioma-like carcinoma (PLELC). Methods: 75 patients with baseline EBV DNA were included. The relationships between baseline EBV DNA and clinical characteristics, survival and objective response rate were analyzed. Results: The baseline EBV DNA levels were related to the liver, chest wall, distant lymph node(s) or multiple sites of distant metastasis. The high baseline EBV DNA group (≥41,900 copies/ml) was related to shorter progression-free and overall survival in univariate analysis and remained significant for progression-free survival in multivariate analysis. Conclusion: The baseline EBV DNA is a valuable biomarker for predicting prognosis and reflecting tumor burden in recurrent or metastatic PLELC.

Clinical Significance

Univariate analysis

10.2217/fon-2023-0722

Cite

Citations (2)

Preparation and capacitance behavior of manganese oxide hollow structures with different morphologies via template-engaged redox etching

Journal of Power Sources (2013)

Yan Gu Jianwei Cai Mingze He Liping Kang Zhibin Lei

Horizontal scan rate

Specific surface area

10.1016/j.jpowsour.2013.03.125

Cite

Citations (48)

Metabolite profiling of steroidal glycosides in the rhizome of Aspidistra sichuanensis using UPLC/Q-TOF MS E

International Journal of Mass Spectrometry (2017)

Jie Peng Yang Zhao Xu Lu Liping Kang Jiang-ming Cui

Fragmentation

10.1016/j.ijms.2017.02.007

Cite

Citations (14)

[Dead heart of pith-decayed Scutellariae Radix: a study based on multi-omics].

Jin-Xiu Qian Yapeng Wang Huaizhu Li Yan-Meng Liu Yihan Wang

Dead heart is an important trait of pith-decayed Scutellariae Radix. The purpose of this study was to clarify the scientific connotation of the dead heart using multi-omics. Metabolomics and transcriptomics combined with multivariate statistical analysis such as principal component analysis(PCA) and partial least squares discriminant analysis(PLS-DA) were used to systematically compare the differences in chemical composition and gene expression among phloem, outer xylem and near-dead xylem of pith-decayed Scutella-riae Radix. The results revealed significant differences in the contents of flavonoid glycosides and aglycones among the three parts. Compared with phloem and outer xylem, near-dead xylem had markedly lowered content of flavonoid glycosides(including baicalin, norwogonin-7-O-β-D-glucuronide, oroxylin A-7-O-β-D-glucuronide, and wogonoside) while markedly increased content of aglycones(including 3,5,7,2',6'-pentahydroxy dihydroflavone, baicalin, wogonin, and oroxylin A). The differentially expressed genes were mainly concentrated in KEGG pathways such as phenylpropanoid metabolism, flavonoid biosynthesis, ABC transporter, and plant MAPK signal transduction pathway. This study systematically elucidated the material basis of the dead heart of pith-decayed Scutellariae Radix with multiple growing years. Specifically, the content of flavonoid aglycones was significantly increased in the near-dead xylem, and the gene expression of metabolic pathways such as flavonoid glycoside hydrolysis, interxylary cork development and programmed apoptosis was significantly up-regulated. This study provided a theoretical basis for guiding the high-quality production of pith-decayed Scutellariae Radix.

Pith

Phenylpropanoid

Flavonoid Biosynthesis

Wogonin

KEGG

10.19540/j.cnki.cjcmm.20230414.101

Cite

Citations (0)

[Effects of different drying methods on content of main chemical compounds in Callicarpae Nudiflorae Folium].

Xiaoyan Hou Xiao-Yan Lan Li-Wan Zhu Zi‐Dong Qiu Xiang Li

This study aims to identify the main chemical compounds, investigate the effects of different drying methods on the quality, and determine the appropriate drying method of Callicarpae Nudiflorae Folium. UPLC-UV-Q-TOF-MS was employed to characterize and identify 35 main compounds, including phenylethanoid glycosides, flavonoids, and iridoids in Callicarpae Nudiflorae Folium. A method for the simultaneous determination of 8 compounds with strong UV absorption and high content was established to evaluate the quality of Callicarpae Nudiflorae Folium dried by different methods. UPLC-UV-Q-TOF-MS combined with principal component analysis(PCA) was employed to compare the Callicarpae Nudiflorae Folium samples treated by microwave drying at different power(119, 231, and 385 W), drying in the shade, sun drying, and oven drying at different temperatures(50, 60, 70, 80, 90, and 100 ℃). The total content of decaffeoyl acteoside, picroside Ⅲ, galuteolin, forsythin B, acteoside, isoacteoside, 6-hydroxyluteolin-7-glucoside, and caffeic acid in Callicarpae Nudiflorae Folium, as well as the content of most compounds, decreased with the rise in drying temperature and with the decrease in microwave power. Considering the content of compounds, low carbon, and energy saving, microwave drying at 231 W, low-temperature drying, or natural drying is recommended for the production of Callicarpae Nudiflorae Folium. This study provides a scientific basis for the selection of drying methods for Callicarpae Nudiflorae Folium at the place of origin and for the improvement of quality standards.

Folium of Descartes

Content (measure theory)

10.19540/j.cnki.cjcmm.20240815.301

Cite

Citations (0)

Region-specific constitutive modeling of the plantar soft tissue

Biomechanics and Modeling in Mechanobiology (2018)

Haihua Ou Peng Zhan Liping Kang Jialiang Su Xiao Hu

Hyperelastic material

Indentation

10.1007/s10237-018-1032-9

Cite

Citations (9)

Supplementary Tables 1-2 from Inhibition of JNK Signaling Overcomes Cancer-Associated Fibroblast-Mediated Immunosuppression and Enhances the Efficacy of Immunotherapy in Bladder Cancer

Chengying Cui H Zhang Congcong Yang Mingwei Yin Xinkun Teng

<p>Supplementary Tables 1-2</p>

Immunosuppression

Cancer Immunotherapy

10.1158/0008-5472.28032359

Cite

Citations (0)

Pennogenin tetraglycoside stimulates secretion-dependent activation of rat platelets: Evidence for critical roles of adenosine diphosphate receptor signal pathways

Thrombosis Research (2012)

Yue Cong Xiaolan Liu Liping Kang Zu‐Yin Yu Zhenhu Zhao

Dense granule

Apyrase

Adenosine diphosphate

P2Y receptor

Granule (geology)

10.1016/j.thromres.2012.02.001

Cite

Citations (17)

More pages