Electrocardiograph, Freecod data collecting system and dynamics GPS are utilized to study the relationship between augmentation of heart rate and distance, as well as driving velocity. Two models are obtained. The prediction results are compared and consistent with each other, so the models are correct validated by each other. This research can help us to analyze the effects of driving environment on drivers' physiological conditions and also offer theory for driver management.
Objective To investigate the effect of rhPTH (1-34) and elcatonin on bone metabolism and serum secreted protein acidic and rich in cysteine ( SPARC ) in postmenopausal women with osteoporosis.Methods One hundred and twenty-four postmenopausal women with osteoporosis were randomly divided into 2 groups:One group was treated with recombinant human parathyroid hormone ( 1-34 ) [ rhPTH ( 1-34 ) ] 200 U/d by subcutaneous injection (PTH group,n =89 )and another group was treated with elcatonin 20 U/week by intramuscular injection (CT group,n =35 ) for 12 months.All patients received a basic therapy with oral calcium ( Ca 600 mg+ Vit D3125 U,q..d.).The bone mineral density ( BMD ) of lumbar spine( L2-4 ),the left femoral neck,greater trochanter,and Ward's triangle,serum calcium and phosphate were measured by baseline,6 months' and 12 months.Levels of serum bone-specific alkaline phosphatase( BSAP),serum secreted protein acidic and rich in cysteine (SPARC)were determined by an ELISA assay.Results By 12 months,rhPTH ( 1-34 ) treatment significantly increased the lumbar spine L2-4 BMD 7.9％ (P＜0.05),serum calcium 8.3 ％ ( P＜ 0.05 ),serum BSAP 93.4％ ( P＜ 0.05 ),serum SPARC by 12.6％[ ( 195.68±59.57 vs 173.81 ±81.33 ) pμg/L,P＜0.05 ].Elcatonin therapy increased the lumbar spine L2-4 BMD by 3.2％ (P＜0.05) at the end of 12 months,but elcatonin did not influence serum calcium,BSAP and SPARC.The rhPTH( 1-34 ) increased lumbar spine L2-4 BMD more than elcatonin did at 12 months( P＜0.05 ).Conclusion rhPTH (1-34) could promote the bone anabolism more effectively than elcatonin did.Serum SPARC may play an important role in promoting osteogenesis by rhPTH.
Key words:
Recombinant human parathyroid hormone (1-34); Elcatonin; Osteoporosis; Secreted protein acidic and rich in cysteine
Based on chromogenic reaction of quaternary ammonium salt type cationic surfactants with 1-(4-nitrophenyl)-3-(4-phenylazophenyl)triazene(cadion NPPAPT),a new method for spectrophotometric determination of polypropylene oxide quaternary ammonium salt type cationic surfactant(CP-60) was established.Test results showed that the maximum wavelength is 382 nm.Within range of mass concentration of surfactant solution 0~0.13 mg·L-1,the relationship between the absorption and the concentration follows Beer's law.This method was directly applied to quaternary ammonium salt type cationic surfactants of the smaller relative molecular weight such as dodecyldimethylbenzylammonium chloride(1227) and cetylpyridinium bromide(CPB),and satisfactory results were also obtained.
Objective To investigate changes in serum sclerostin (SO) in postmenopausal women before and after treatment with recombinant human parathyroid hormone (1-34) [rhPTH (1-34)],and to explore the relationship of serum SO with estradiol (E2),and bone mineral density (BMD).Methods Ninety-five postmenopausal women were divided into normal BMD group (n =41) and osteoporosis group (n =54).Body mass index,alkaline phosphatase (ALP),serum E2,calcium,phosphate,and SO were determined in both groups.The patients in osteoporosis group were treated with rhPTH (1-34) 20 μg/d by subcutaneous injection and oral calcium 500 mg/d for 12 months.Serum calcium,serum phosphate,BMD,serum ALP,serum E2,and sclerostin were determined in osteoporosis group by 6 months and 12 months of treatment.Results (1) Serum level of SO in osteoporosis group was raised significantly as compared with normal BMD group (P ＜ 0.05) ; E2 and BMD were negatively correlated with SO; age and postmenopausal years were positively correlated with SO (P ＜ 0.05).(2) Serum SO was reduced gradually with treatment of rhPTH (1-34) by 6 months and 12 months (P ＜ 0.05).Conclusions Serum SO was increased in postmenopausal women,which was related to E2 and BMD,and was reduced gradually with treatment of rhPTH (1-34).SO may participate in the development of postmenopausal osteoporosis.
Key words:
Recombinant human parathyroid hormone (1-34) ; Sclerostin; Osteoporosis; Postmenopausal
Reciprocal theorem method(RTM) is generalized to solve the problem of bending of thick rectangular plate under concentrated load based on Reissner's theory.The exact solution and the analysis of the thick plate with simply supported edges are given.
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