Hyun Chul Lim

Severance Hospital

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Hyojin Park

Gangnam Severance Hospital

Young Hoon Youn

Gangnam Severance Hospital

Jie‐Hyun Kim

Gangnam Severance Hospital

Sang In Lee

Pusan National University

Hye‐Kyung Jung

Ewha Womans University Medical Center

Jeong Eun Shin

Dankook University Hospital

Kyung Ho Song

National Health Insurance Service Ilsan Hospital

Suck Chei Choi

Wonkwang University

Joong Goo Kwon

Catholic University of Daegu

Tae Hee Lee

Soonchunhyang University

Cooperative Institutions

Yonsei University

Severance Hospital

Sungkyunkwan University

Gangnam Severance Hospital

Seoul National University

Catholic University of Korea

Samsung Medical Center

Korea University

Ajou University

Seoul National University Hospital

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한국인 헬리코박터 파일로리 감염 치료 근거 기반 임상진료지침 개정안 2020

Hye-Kyung Jung Seung Joo Kang Yong Chan Lee Hyo‐Joon Yang Seon-Young Park

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Clinical Experience of Central Resection and Fusion Procedure for Bifid Thumb

The Journal of the Korean Orthopaedic Association (1987)

Jaewon Chang S.H. Lee Hyun Chul Lim Su-Young Bae

10.4055/jkoa.1987.22.3.805

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CCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells

Immunobiology (2012)

Bunsoon Choi Hyun Chul Lim Eun‐So Lee A.K.M. Mostafa Anower Seonghyang Sohn

CCR7 and its ligand, CCL21, are known to establish microenvironments for the initiation of immune responses in secondary lymphoid tissue. It has also been reported that CCR7 ligand gene-deleted mice have defects in lymphocyte homing. In addition, the injection of the CCR7 ligand was shown to induce the expression of memory T cells. In this study, we analyzed the expression of CCR7 and its ligand in HSV-induced Behçet's disease (BD)-like inflammation of mice. Additionally, plasmids containing the CCR7 ligand CCL19 or CCL21, pcDNA3.1-CCL19 or pcDNA3.1-CCL21, respectively, were injected into symptomatic mice, and changes in the population of memory T cells were determined. After administration of pcDNA3.1-CCL21, the frequencies of CD8+CD44+, CD8+CD62L− memory T cells were significantly up-regulated and the symptoms were not deteriorated when compared to the control vector injected group. Specifically, the difference in frequencies of CCR7+ peripheral blood mononuclear cells between active BD patients and inactive BD patients was similar to that of HSV-induced BD-like mice. These results suggest that CCR7, its ligand, and CD8+ memory cells are correlated with the regulation of BD symptoms.

CCL19

CCL21

Memory T cell

10.1016/j.imbio.2012.07.003

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The increase in balloon size to over 15 mm does not affect the development of pancreatitis after endoscopic papillary large balloon dilatation for bile duct stone removal.

Young Hoon Youn Hyun Chul Lim Jae Hoon Jahng Sung Ill Jang Jung Hwan You

Endoscopic papillary large balloon dilatation (EPLBD) after endoscopic sphincterotomy (EST) has recently become widely used for common bile duct (CBD) stone removal, but many clinicians remain concerned about post-procedural pancreatitis with increasing the balloon size to over 15 mm. We aimed to evaluate the safety and efficacy of EPLBD with a relatively large balloon (15–20 mm) after EST and to evaluate the factors related to post-EPLBD pancreatitis. A retrospective review was undertaken of the endoscopic database of 101 patients with CBD stones who underwent EPLBD using a larger balloon size of over 15 mm (15–20 mm). Clinical parameters, endoscopic data, and outcomes were analyzed. The mean age of the subjects was 69 years. All patients had a dilated CBD of over 11 mm (mean = 22.6 mm). The mean size of balloon used in EPLBD was 17.1 ± 1.9 mm (range 15–20 mm). Mechanical lithotripsy was required in seven patients (6.9%). The rate of complete stone removal in the first session was 92.1%. Post-procedural pancreatitis developed in five cases (5.4%), but none were graded as severe. The smaller dilatation of the CBD, longer cannulation time, and longer time for stone removal were associated with post-procedural pancreatitis, but larger size of balloon did not affect the development of post-EPLBD pancreatitis. EPLBD with a large balloon of over 15 mm with EST is an effective and safe procedure with a very low probability of severe post-procedural pancreatitis. Post-EPLBD pancreatitis was not associated with larger balloon size, but was associated with longer procedure time and smaller dilatation of the CBD.

Balloon dilation

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2022 Seoul Consensus on Clinical Practice Guidelines for Functional Constipation

Journal of Neurogastroenterology and Motility (2023)

Young Sin Cho Yoo Jin Lee Jeong Eun Shin Hye‐Kyung Jung Seon‐Young Park

Young Sin Cho, Yoo Jin Lee, Jeong Eun Shin, Hye-Kyung Jung, Seon-Young Park, Seung Joo Kang, Kyung Ho Song, Jung-Wook Kim, Hyun Chul Lim, Hee Sun Park, Seong-Jung Kim, Ra Ri Cha, Ki Bae Bang, Chang Seok Bang, Sung Kyun Yim, Seung-Bum Ryoo, Bong Hyeon Kye, Woong Bae Ji, Miyoung Choi, In-Kyung Sung, and Suck Chei Choi,; the Korean Society of Neurogastroenterology and Motility. J Neurogastroenterol Motil 2023;29:271-305. https://doi.org/10.5056/jnm23066

10.5056/jnm23066

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2019 Seoul Consensus on Esophageal Achalasia Guidelines

Journal of Neurogastroenterology and Motility (2020)

Hye‐Kyung Jung Su Jin Hong Oh Young Lee John E. Pandolfino Hyojin Park

Esophageal achalasia is a primary motility disorder characterized by insufficient lower esophageal sphincter relaxation and loss of esophageal peristalsis. Achalasia is a chronic disease that causes progressive irreversible loss of esophageal motor function. The recent development of high-resolution manometry has facilitated the diagnosis of achalasia, and determining the achalasia subtypes based on high-resolution manometry can be important when deciding on treatment methods. Peroral endoscopic myotomy is less invasive than surgery with comparable efficacy. The present guidelines (the "2019 Seoul Consensus on Esophageal Achalasia Guidelines") were developed based on evidence-based medicine; the Asian Neurogastroenterology and Motility Association and Korean Society of Neurogastroenterology and Motility served as the operating and development committees, respectively. The development of the guidelines began in June 2018, and a draft consensus based on the Delphi process was achieved in April 2019. The guidelines consist of 18 recommendations: 2 pertaining to the definition and epidemiology of achalasia, 6 pertaining to diagnoses, and 10 pertaining to treatments. The endoscopic treatment section is based on the latest evidence from meta-analyses. Clinicians (including gastroenterologists, upper gastrointestinal tract surgeons, general physicians, nurses, and other hospital workers) and patients could use these guidelines to make an informed decision on the management of achalasia.

10.5056/jnm20014

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Citations (98)

Su1871 Effects of DA-9701, a Prokinetic Agent on Gastric Motor Function in Guinea Pig; In Vivo and In Vitro Study

Gastroenterology (2015)

Hyun Chul Lim Hyojin Park Young Ju Lee

Prokinetic agent

10.1016/s0016-5085(15)31807-2

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T2060 The Clinical Course of Post-Infectious Irritable Bowel Syndrome: An Eight-Year Follow-up Study

Gastroenterology (2010)

Hyun Chul Lim Jie‐Hyun Kim Young Hoon Youn Hyojin Park Sang In Lee

10.1016/s0016-5085(10)62873-9

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Endoscopic Role for the Management of Postoperative Intraluminal Complications of Laparoscopic Assistant Gastrectomy

Gastrointestinal Endoscopy (2009)

Kee Myung Lee Sun-Gyo Lim Su Jin Jeon Sung Jae Shin Jin Hong Kim

Endoscopic treatment

Billroth I

10.1016/j.gie.2009.03.494

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Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro

Yonsei Medical Journal (2008)

Hyun Chul Lim Young Gyun Kim Jung Hyun Lim Hee Sun Kim Hyojin Park

Purpose: Itopride hydrochloride (itopride) inhibits acetylcholinesterase (AChE) and antagonizes dopamine D2 receptor, and has been used as a gastroprokinetic agent.However, its prokinetic effect on the small bowel or colon has not yet been thoroughly investigated.The aim of this study was to investigate the effects of itopride on motor functions of the ileum and colon in guinea pigs.Materials and Methods: The distal ileum was excised and the activity of peristaltic contraction was determined by measuring the amplitude and propagation velocity of peristaltic contraction.The distal colon was removed and connected to the chamber containing Krebs-Henseleit solution (K-H solution).Artificial fecal matter was inserted into the oral side of the lumen, and moved toward the anal side by intraluminal perfusion via peristaltic pump.Colonic transit times were measured by the time required for the artificial feces to move a total length of 10 cm with 2-cm intervals.Results: In the ileum, itopride accelerated peristaltic velocity at higher dosage (10 -10 -10 -6 M) whereas neostigmine accelerated it only with a lower dosage (10 -10 -10 -9 M).Dopamine (10 -8 M) decelerated the velocity that was recovered by itopride infusion.Itopride and neostigmine significantly shortened colonic transit at a higher dosage (10 -10 -10 -6 M).Dopamine (10 -8 M) delayed colonic transit time that was also recovered after infusion of itopride.Conclusion: Itopride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor.

Peristalsis

Prokinetic agent

Ascending colon

10.3349/ymj.2008.49.3.472

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Citations (24)