Bridget T. Hill

Alfred Health

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Richard D. H. Whelan

The Honourable Society of Lincoln's Inn

L A Price

Novartis (United Kingdom)

Louise K. Hosking

GlaxoSmithKline (United Kingdom)

Anna Kruczynski

Pierre Fabre (France)

Chantal Etiévant

Pierre Fabre (France)

Sharon A. Shellard

The Honourable Society of Lincoln's Inn

Dominique Perrin

Merck (Germany)

Wolfram C. M. Dempke

Ludwig-Maximilians-Universität München

Jean‐Marc Barret

Centre National de la Recherche Scientifique

Angela S. Bellamy

The Honourable Society of Lincoln's Inn

Cooperative Institutions

Pierre Fabre (France)

Centre National de la Recherche Scientifique

Heidelberg University

Kiel University

Inserm

University of Tübingen

The Honourable Society of Lincoln's Inn

National Cancer Institute

Goethe University Frankfurt

University College London

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Eighteenth-century Women

Routledge eBooks (2013)

Bridget T. Hill

When it was first published in 1984, this book filled an acknowledged gap in the social history of the period and made available hitherto inaccessible sources. The work draws on newspapers and journals, memoirs, diaries, courtesy books, county surveys and records, but also on the literature of the period, its novels, poetry and plays. It examines the role assigned to women in eighteenth-century society and the education thought fitting to perform it. It looks at attitudes to courtship and marriage, chastity and sexual passion. It explores the role of women as wives and mothers, as spinsters and widows, and focuses on the living and working experience of women whether in the home, agriculture, industry or domestic service. It contrasts the expectations of the rich and the poor, the leisured lady and the underpaid female agricultural labourer, the unmarried mother and the prostitute.

Courtesy

Passion

Romance

10.4324/9780203104071

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Citations (4)

Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid

Cancer Chemotherapy and Pharmacology (1998)

Anna Kruczynski Françis C. Colpaert Jean-Pierre Tarayre Pierre Mouillard Jacques Fahy

Vinorelbine

Vinca alkaloid

Vinca

10.1007/s002800050764

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Citations (114)

Some effects of chlorambucil on enzymes of glutathione metabolism in drug-sensitive and -resistant strains of the Yoshida ascites sarcoma

Biochemical Journal (1969)

Kenneth R. Harrap Robert Jackson Bridget T. Hill

1. Yoshida ascites cells from a strain sensitive to chemotherapy with alkylating agents contained elevated activities of the two enzymes directly responsible for glutathione synthesis, in comparison with a resistant cell strain. The activities of the glutathione-degrading enzyme gamma-glutamyltranspeptidase were comparable in both cell strains. 2. After parenteral administration of chlorambucil to rats carrying either strain of tumour, the activities of the glutathione-synthetic enzymes increased in the sensitive cells, but remained unchanged in the resistant cells. Drug treatment was without effect on the gamma-glutamyltranspeptidase activity of either cell strain. 3. The activities of a number of enzymes concerned in the oxidoreduction of glutathione remained unchanged after the administration of chlorambucil to rats carrying either strain of cells.

Chlorambucil

Strain (injury)

Neoplasm

10.1042/bj1110603

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Citations (7)

Zelluläre Grundlagen der Interaktionen zwischen Zytostatika und ionisierenden Strahlen

Springer eBooks (1992)

Wolfram C. M. Dempke Bridget T. Hill R. Osieka

10.1007/978-3-642-76187-4_56

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Over-expression of P-glycoprotein and glutathione S-transferase PI in MCF-7 cells selected for vincristine resistancein vitro

International Journal of Cancer (1992)

Richard D. H. Whelan Clare J. Waring C. Roland Wolf John D. Hayes Louise K. Hosking

This study has provided evidence that exposure of the wild-type MCF-7 human breast carcinoma cell line to the mutagen ethyl methane sulphonate (EMS), followed by selection in vincristine (VCR), resulted in a stably-resistant subline, designated VCREMS, which expressed an approximately 14-fold level of resistance to VCR. This VCREMS subline showed cross-resistance (3-fold) to adriamycin (ADR) and to etoposide (3-fold), but not to cisplatin. The addition of a non-toxic concentration of verapamil (6.6 microM) significantly enhanced VCR cytotoxicity only in the resistant subline. This resistance was associated with over-expression of P-glycoprotein (Pgp), but without a concomitant increase in Pgp mRNA or gene amplification. In addition, activities of total glutathione S-transferases (GST) and glutathione peroxidase were elevated in this resistant subline, with over-expression of the GST-pi isozyme and its associated mRNA being identified, without gene amplification. This VCR-selected resistant MCF-7 cell line therefore provides another example of a breast carcinoma subline in which there is co-ordinate over-expression of both Pgp and GST-pi, without attributing a causal relationship to either event, and extends the range of anti-tumour drugs known to elicit modifications in glutathione metabolism.

MCF-7

P-glycoprotein

10.1002/ijc.2910520215

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Citations (44)

Women, work, and sexual politics in eighteenth-century England

Choice Reviews Online (1990)

Bridget T. Hill

Pinchbeck and after the social context women's work in the family economy the undermining of the family economy female servants in husbandry female apprenticeship housework domestic service ignored, unrecorded and invisible - some occupations of women the economics of courtship and marriage clarity and obscurity in the law relating to wives, property and marriage spinsters and spinsterhood widows.

10.5860/choice.28-0470

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Citations (64)

Collateral Sensitivity and Cross-Resistance

Handbook of experimental pharmacology (1984)

Bridget T. Hill

10.1007/978-3-642-69490-5_24

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Citations (16)

Effect of Chlorambucil on Thymidine Utilization by Yoshida Ascites Tumor Cells 2

JNCI Journal of the National Cancer Institute (1973)

Bridget T. Hill Martin H.N. Tattersall

Journal Article Effect of Chlorambucil on Thymidine Utilization by Yoshida Ascites Tumor Cells Get access Bridget T. Hill, Bridget T. Hill Chester Beatty Research Institute, Institute of Cancer Research, Fulham Road, London SW3 6JB U.K. Search for other works by this author on: Oxford Academic PubMed Google Scholar Martin H. N. Tattersall Martin H. N. Tattersall Chester Beatty Research Institute, Institute of Cancer Research, Fulham Road, London SW3 6JB U.K. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 51, Issue 4, October 1973, Pages 1387–1390, https://doi.org/10.1093/jnci/51.4.1387 Published: 01 October 1973 Article history Received: 26 June 1973 Accepted: 17 July 1973 Published: 01 October 1973

Chlorambucil

10.1093/jnci/51.4.1387

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Citations (3)

Characterization of DNA-strand breakage induced in V79 cells by F 11782, a catalytic inhibitor of topoisomerases

British Journal of Cancer (2000)

J-M Barret Bridget T. Hill Peggy L. Olive

DNA damage induced in V79 cells by F 11782, or 2",3"-bis pentafluorophenoxyacetyl-4',6'-ethylidene-beta-D glucoside of 4'-phosphate-4'-demethylepipodophyllotoxin 2N-methyl glucamine salt, a novel dual catalytic inhibitor of topoisomerases I and II, was investigated using both alkaline and neutral versions of the comet assay methodology. A comparison was then made of the DNA damage induced by F 11782 with that induced by either etoposide or camptothecin under comparable experimental conditions. The results revealed that F 11782 initially induced less DNA strand breaks that either etoposide or camptothecin and rejoined such breaks more slowly. However, unlike these other drugs, the extent of DNA damage induced by F 11782 increased linearly with time of incubation. F 11782 produced both DNA single- and double-strand breaks without any clear specificity relative to phase of the cell cycle, although proliferating cells were preferentially damaged. The marked time-dependency of induction of DNA strand breaks by F 11782 may serve to explain, at least in part, its major in vivo antitumour activities.

10.1054/bjoc.2000.1514

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Citations (16)

Synthesis of 9‐Acridinyl Sulfur Derivatives: Sulfides, Sulfoxides and Sulfones. Comparison of Their Activity on Tumor Cells.

ChemInform (2005)

Christiane Santelli‐Rouvier Jean‐Marc Barret Christopher M. Farrell Derek Sharples Bridget T. Hill

Abstract For Abstract see ChemInform Abstract in Full Text.

10.1002/chin.200519164

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Citations (1)