Juan A. Vílchez

Santa Lucía University General Hospital

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Francisco Marı́n

Centro de Investigación en Red en Enfermedades Cardiovasculares

Mariano Valdés

Hospital Universitario Virgen de la Arrixaca

Joaquim Casal

Universitat Politècnica de Catalunya

Vanessa Roldán

Hospital General Universitario Morales Meseguer

Diana Hernández‐Romero

Universidad de Murcia

Josep Arnaldos

Universitat Politècnica de Catalunya

Vicente Vicente

Instituto de Salud Carlos III

Gregory Y.H. Lip

University of Liverpool

Sergio Manzano‐Fernández

Hospital Universitario Virgen de la Arrixaca

Eulàlia Planas

Universitat Politècnica de Catalunya

Cooperative Institutions

Hospital Universitario Virgen de la Arrixaca

Instituto Murciano de Investigación Biosanitaria

Universidad de Murcia

Centro de Investigación en Red en Enfermedades Cardiovasculares

Centro de Investigación Biomédica en Red

Universitat Politècnica de Catalunya

Santa Lucía University General Hospital

University of Birmingham

Hospital General Universitario Morales Meseguer

Universitat Autònoma de Barcelona

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New Trends in Biomarkers and Diseases Research: An Overview

Juan A. Vílchez María Dolores Albaladejo-Otón Ana M. Moreno-Fuentes África de Béjar-Almira Anna Hernández‐Aguilera

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Comparative Determination and Monitoring of Biomarkers of Necrosis and Myocardial Remodeling between Radiofrequency Ablation and Cryoablation

Pacing and Clinical Electrophysiology (2012)

Diana Hernández‐Romero Francisco Marı́n Vanessa Roldán Pablo Peñafiel-Verdú Juan A. Vílchez

Background Biomarkers of necrosis and inflammation have been found raised after radiofrequency ablation (RF). There is scarce information on biomarkers’ behavior after cryoablation. Our aim was to study biomarkers of necrosis, inflammation, and interstitial remodeling after two different approaches: RF versus cryoablation. Methods We studied 22 consecutive patients with atrial flutter who underwent RF (10) or cryoablation (12). All patients underwent electrophysiological study and subsequent ablation. Peripheral samples were collected before the procedure, immediately after, the following day, 3 days, 1 week, 1 month, and 2 months after ablation. Samples were assayed for biomarkers of inflammation (high sensitive C‐reactive protein [hs‐CRP]) and tissue remodeling (C‐propeptide of type I procollagen [CICP], matrix metalloproteinase 2 [MMP‐2], matrix metalloproteinase 9 [MMP‐9], and metallopeptidase inhibitor 1 [TIMP‐1]). We also determined biomarkers of tissue necrosis (creatine kinase [CK], its MB isoenzyme, cardiac troponin I [TnI], and troponin T (TnT)] in samples obtained immediately after ablation, 6 hours postablation, and 12 hours postablation. Results Bidirectional isthmus block was achieved in all patients. We found significantly higher levels of CK, CK‐MB, and TnI after cryoablation compared to RF ablation for all timing samples. These necrosis biomarkers showed significant differences depending on the time (all P < 0.001), and the interaction between the time and the used ablation approach (P = 0.005, P < 0.001, and P < 0.001, respectively). For patients who undergoing RF ablation, MMP‐2 showed the greatest changes depending on the interaction between time and number of applications (P = 0.041), whereas for patients who undergoing cryoablation, CK was the most relevant biomarker depending on the interaction between time and number of applications (P = 0.006). Conclusions We show higher levels of necrosis and myocardial injury biomarker after cryoablation versus RF. However, we found higher remodeling processes after RF. Our data support previous publications showing different lesion formation in cryoablation and RF. (PACE 2013; 36:31–36)

Cryoablation

10.1111/pace.12017

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Plasma levels of Von Willebrand factor are increased in patients with hypertrophic cardiomyopathy

Thrombosis Research (2010)

Francisco Cambronero Juan A. Vílchez Antonio García‐Honrubia Francisco Ruíz-Espejo Victoria Moreno

Plasma levels

10.1016/j.thromres.2010.01.010

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Citations (17)

P3850Refining stroke and bleeding risk prediction by adding consecutive biomarkers to CHA2DS2-VASc and HAS-BLED scores

European Heart Journal (2018)

Juan Manuel Caravaca María Asunción Esteve‐Pastor Juan A. Vílchez Josefa Gálvez Vicente Vicente

CHA2DS2–VASc score

Stroke

Stroke risk

10.1093/eurheartj/ehy563.p3850

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Characteristics and laboratory findings on admission to the emergency department among 2873 hospitalized patients with COVID-19: the impact of adjusted laboratory tests in multicenter studies. A multicenter study in Spain (BIOCOVID-Spain study)

Scandinavian Journal of Clinical and Laboratory Investigation (2021)

Luis García de Guadiana‐Romualdo Daniel Morell‐García Cristian Morales‐Indiano Josep Miquel Bauçà Maria José Alcaide Martín

Identification of predictors for severe disease progression is key for risk stratification in COVID-19 patients. We aimed to describe the main characteristics and identify the early predictors for severe outcomes among hospitalized patients with COVID-19 in Spain. This was an observational, retrospective cohort study (BIOCOVID-Spain study) including COVID-19 patients admitted to 32 Spanish hospitals. Demographics, comorbidities and laboratory tests were collected. Outcome was in-hospital mortality. For analysis, laboratory tests values were previously adjusted to assure the comparability of results among participants. Cox regression was performed to identify predictors. Study population included 2873 hospitalized COVID-19 patients. Nine variables were independent predictors for in-hospital mortality, including creatinine (Hazard ratio [HR]:1.327; 95% Confidence Interval [CI]: 1.040-1.695, p = .023), troponin (HR: 2.150; 95% CI: 1.155-4.001; p = .016), platelet count (HR: 0.994; 95% CI: 0.989-0.998; p = .004) and C-reactive protein (HR: 1.037; 95% CI: 1.006-1.068; p = .019). This is the first multicenter study in which an effort was carried out to adjust the results of laboratory tests measured with different methodologies to guarantee their comparability. We reported a comprehensive information about characteristics in a large cohort of hospitalized COVID-19 patients, focusing on the analytical features. Our findings may help to identify patients early at a higher risk for an adverse outcome.

10.1080/00365513.2021.1881997

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Citations (23)

Apixaban Compared With Warfarin for Stroke Prevention in Atrial Fibrillation

Circulation (2013)

Pilar Gallego Juan A. Vílchez Deirdre A. Lane

C linical guidelines 1,2 advocate the use of oral anticoagu- lation, whether a vitamin K antagonist (VKA) or 1 of the novel agents, for stroke prevention in patients with atrial fibrillation who have ≥1 risk factors for stroke.The benefits of traditional oral anticoagulants (VKAs), in terms of a reduction in stroke and major bleeding events, are experienced only over a narrow therapeutic window (international normalized ratio [INR] of 2.0-3.0).Their intricate pharmacokinetic profile with a slow onset and offset of action and numerous drug, food, and alcohol interactions, as well as genetic, ethnicity, and age-related differences in dose response, necessitates regular INR monitoring.

Stroke

General hospital

Apixaban

10.1161/circulationaha.113.003132

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Citations (15)

The Effects of One-Anastomosis Gastric Bypass on Glucose Metabolism in Goto-Kakizaki Rats

Obesity Surgery (2016)

Lorea Zubiaga Rafael Abad Jaime Ruíz-Tóvar Pablo Enriquez Juan A. Vílchez

Carbohydrate Metabolism

10.1007/s11695-016-2138-8

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Citations (15)

Predicting the flammable region reach of propane vapor clouds

Journal of Loss Prevention in the Process Industries (2013)

Juan A. Vílchez Diana Villafañe Joaquim Casal

Flammability limit

Flammable liquid

Propane

Spillage

10.1016/j.jlp.2013.11.005

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Citations (6)

Cardiac troponin and COVID‐19 severity: Results from BIOCOVID study

European Journal of Clinical Investigation (2021)

Luis García de Guadiana‐Romualdo Daniel Morell‐García Olaia Rodríguez‐Fraga Cristian Morales‐Indiano Ana María Lourdes Padilla Jiménez

Abstract Background Myocardial injury is a common finding in COVID‐19 strongly associated with severity. We analysed the prevalence and prognostic utility of myocardial injury, characterized by elevated cardiac troponin, in a large population of COVID‐19 patients, and further evaluated separately the role of troponin T and I. Methods This is a multicentre, retrospective observational study enrolling patients with laboratory‐confirmed COVID‐19 who were hospitalized in 32 Spanish hospitals. Elevated troponin levels were defined as values above the sex‐specific 99th percentile upper reference limit, as recommended by international guidelines. Thirty‐day mortality was defined as endpoint. Results A total of 1280 COVID‐19 patients were included in this study, of whom 187 (14.6%) died during the hospitalization. Using a nonspecific sex cut‐off, elevated troponin levels were found in 344 patients (26.9%), increasing to 384 (30.0%) when a sex‐specific cut‐off was used. This prevalence was significantly higher (42.9% vs 21.9%; P < .001) in patients in whom troponin T was measured in comparison with troponin I. Sex‐specific elevated troponin levels were significantly associated with 30‐day mortality, with adjusted odds ratios (ORs) of 3.00 for total population, 3.20 for cardiac troponin T and 3.69 for cardiac troponin I. Conclusion In this multicentre study, myocardial injury was a common finding in COVID‐19 patients. Its prevalence increased when a sex‐specific cut‐off and cardiac troponin T were used. Elevated troponin was an independent predictor of 30‐day mortality, irrespective of cardiac troponin assay and cut‐offs to detect myocardial injury. Hence, the early measurement of cardiac troponin may be useful for risk stratification in COVID‐19.

Troponin T

10.1111/eci.13532

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Citations (58)

Historical analysis of accidents in the transportation of natural gas

Journal of Hazardous Materials (1996)

Helena Montiel Juan A. Vílchez Josep Arnaldos Joaquim Casal

Containment (computer programming)

10.1016/s0304-3894(96)01819-5

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Citations (93)