Hai-Jun Hu

Shanghai University of Traditional Chinese Medicine

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Zhengtao Wang

State Administration of Traditional Chinese Medicine of the People's Republic of China

Li Yang

Shanghai University of Traditional Chinese Medicine

Zhu‐Zhen Han

State Administration of Traditional Chinese Medicine of the People's Republic of China

Yingbo Yang

Shanghai University of Traditional Chinese Medicine

Yanhong Shi

City of Hope

Shusheng Zhang

Zhengzhou University

Yue Zhou

Shanghai Ocean University

Yue Zhou

Shanghai Jiao Tong University

Yanhong Shi

Anhui Agricultural University

Yang Li

State Key Laboratory of Hydraulics and Mountain River Engineering

Cooperative Institutions

Shanghai University of Traditional Chinese Medicine

State Administration of Traditional Chinese Medicine of the People's Republic of China

Chinese Academy of Sciences

Shanghai Jiao Tong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai University

Shanghai Innovative Research Center of Traditional Chinese Medicine

Sichuan University

Kunming Medical University

Fujian Medical University

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Dammarane-type triterpene oligoglycosides from the leaves and stems of Panax notoginseng and their antiinflammatory activities

Journal of Ginseng Research (2017)

Juan Li Rufeng Wang Yue Zhou Hai-Jun Hu Yingbo Yang

Inflammation is widespread in the clinical pathology and closely associated to the progress of many diseases. Triterpenoid saponins as a key group of active ingredients in

Panax notoginseng

Dammarane

Araliaceae

Terpene

10.1016/j.jgr.2017.11.008

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Citations (33)

Abietane Diterpenoids from the Roots of Clerodendrum trichotomum and Their Nitric Oxide Inhibitory Activities

Journal of Natural Products (2018)

Hai-Jun Hu Yue Zhou Zhu‐Zhen Han Yanhong Shi Shu‐Sheng Zhang

Twelve new abietane diterpenoids (1-12) and 31 known analogues (13-43) were isolated from a medicinal Chinese herb, Clerodendrum trichotomum Thunberg. The absolute configurations of 1-3 were established on the basis of ECD and X-ray crystallography data, whereas that of 4 was elucidated by comparison of experimental and calculated ECD data. Eight diterpenoids, 15,16-dehydroteuvincenone G (1), trichotomin A (4), 2α-hydrocaryopincaolide F (7), villosin C (20), 15-dehydro-17-hydroxycyrtophyllone A (22), demethylcryptojaponol (38), 6β-hydroxydemethylcryptojaponol (39), and trichotomone (43), exerted inhibitory effects against NO production with IC50 values of 5.6-16.1 μM. The structure-activity relationships of the isolated diterpenoids are also estimated.

Abietane

10.1021/acs.jnatprod.7b00814

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Citations (24)

Bioactive Diterpenoids and Flavonoids from the Aerial Parts of Scoparia dulcis

Journal of Natural Products (2014)

Qing Liu Qiming Yang Hai-Jun Hu Li Yang Yingbo Yang

Six new diterpenoids, 4-epi-7α-O-acetylscoparic acid A (1), 7α-hydroxyscopadiol (2), 7α-O-acetyl-8,17β-epoxyscoparic acid A (3), neo-dulcinol (4), dulcinodal-13-one (5), and 4-epi-7α-hydroxydulcinodal-13-one (6), and a new flavonoid, dillenetin 3-O-(6″-O-p-coumaroyl)-β-D-glucopyranoside (10), along with 12 known compounds, were isolated from the aerial parts of Scoparia dulcis. The 7S absolute configuration of the new diterpenoids 1-4 and 6 was deduced by comparing their NOESY spectra with that of a known compound, (7S)-4-epi-7-hydroxyscoparic acid A (7), which was determined by the modified Mosher's method. The flavonoids scutellarein (11), hispidulin (12), apigenin (15), and luteolin (16) and the terpenoids 4-epi-scopadulcic acid B (9) and betulinic acid (19) showed more potent α-glucosidase inhibitory effects (with IC50 values in the range 13.7-132.5 μM) than the positive control, acarbose. In addition, compounds 1, 11, 12, 15, 16, and acerosin (17) exhibited peroxisome proliferator-activated receptor gamma (PPAR-γ) agonistic activity, with EC50 values ranging from 0.9 to 24.9 μM.

Betulinic acid

Acarbose

Terpene

10.1021/np500150f

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Citations (41)

Three new C-glycosyflavones with acetyl substitutions from Swertia mileensis

Journal of Natural Medicines (2018)

Xiaolong Liu Yanhong Shi Hai-Jun Hu Jia Li Chunge Li

10.1007/s11418-018-1225-7

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Citations (10)

The relationship between atmospheric water vapor and temperature in simulations of climate change

Geophysical Research Letters (2000)

Hai-Jun Hu Robert J. Oglesby Barry Saltzman

Atmospheric moisture ( Q ) and temperature ( T ) relationships simulated by two general circulation models (GCMs) and that of a recent operational analysis are intercompared. The GCMs represent two important stages of model development, with the earlier one using a simplistic convective adjustment scheme and the more recent one employing a more physically‐realistic convective parameterization. While the models agree in some fundamental qualitative aspects of the Q‐T relationship, they differ quantitatively in the correlations of Q with T , and in the vertical dependencies of moistening to increasing CO 2 . As the sophistication of convective parameterizations has increased, model sensitivity to changes in atmospheric CO 2 has decreased markedly. This study indicates the reduction in sensitivity is primarily due to a reduction in simulated moisture amount along with changes in vertical distributions. While the more recent model shows clear signs of improvements, there is also indication that it may have underestimated the Q‐T correlations, leading to a somewhat lower climate sensitivity with increasing CO 2 .

Atmospheric Circulation

Lapse rate

Atmospheric models

10.1029/2000gl011680

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Citations (15)

Bioactive constituents from Clerodendrum trichotomum and their α-glucosidase inhibitory and PPAR-γ agonist activities

Fitoterapia (2024)

Yingbo Yang Qian Zhang Jia Wang Hai-Jun Hu Meng Wang

10.1016/j.fitote.2024.106266

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Citations (1)

Structure–inhibition relationship of phenylethanoid glycosides on angiotensin-converting enzyme using ultra-performance liquid chromatography-tandem quadrupole mass spectrometry

RSC Advances (2015)

Pengfei Li Meng Qi Hai-Jun Hu Qing Liu Qiming Yang

The structure–inhibition relationship of phenylethanoid glycosides against ACE was investigated by an improved UPLC-MS/MS method. The number of hydroxyl groups and structural steric hindrance were critical for the ACEI of phenylethanoid glycosides.

Phenylethanoid

Tandem

10.1039/c5ra05027h

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Citations (8)

CCDC 1571272: Experimental Crystal Structure Determination

The Cambridge Structural Database (2018)

Hai-Jun Hu Yue Zhou Zhu‐Zhen Han Yanhong Shi Shusheng Zhang

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1pr16p

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Citations (0)

Chemical transformation and target preparation of saponins in stems and leaves of Panax notoginseng

Journal of Ginseng Research (2016)

Rufeng Wang Juan Li Hai-Jun Hu Jia Li Yingbo Yang

Notoginsenoside Ft1 is a promising potential candidate for cardiovascular and cancer disease therapy owing to its positive pharmacological activities. However, the yield of Ft1 is ultralow utilizing reported methods. Herein, an acid hydrolyzing strategy was implemented in the acquirement of rare notoginsenoside Ft1.Chemical profiles were identified by ultraperformance liquid chromatography coupled with quadruple-time-of-flight and electrospray ionization mass spectrometry (UPLC-Q/TOF-ESI-MS). The acid hydrolyzing dynamic changes of chemical compositions and the possible transformation pathways of saponins were monitored by ultrahigh-performance LC coupled with tandem MS (UHPLC-MS/MS).Notoginsenoside Ft1 was epimerized from notoginsenoside ST4, which was generated through cleaving the carbohydrate side chains at C-20 of notoginsenosides Fa and Fc, and vina-ginsenoside R7, and further converted to other compounds via hydroxylation at C-25 or hydrolysis of the carbohydrate side chains at C-3 under the acid conditions. High temperature contributed to the hydroxylation reaction at C-25 and 25% acetic acid concentration was conducive to the preparation of notoginsenoside Ft1. C-20 epimers of notoginsenoside Ft1 and ST4 were successfully separated utilizing solvent method of acetic acid solution. The theoretical preparation yield rate of notoginsenoside Ft1 was about 1.8%, which would be beneficial to further study on its bioactivities and clinical application.

Hydroxylation

Panax notoginseng

Biotransformation

Chemical structure

10.1016/j.jgr.2016.08.009

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Citations (19)

CCDC 1571267: Experimental Crystal Structure Determination

The Cambridge Structural Database (2018)

Hai-Jun Hu Yue Zhou Zhu‐Zhen Han Yanhong Shi Shusheng Zhang

10.5517/ccdc.csd.cc1pr11j

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Citations (0)