Weichang Xue

Chinese Academy of Sciences

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Amit Bandyopadhyay

Washington State University

Susmita Bose

Washington State University

Xuanyong Liu

Chinese Academy of Sciences

Chuanxian Ding

Chinese Academy of Sciences

Xuebin Zheng

Ningbo University

B. Vamsi Krishna

Kalasalingam Academy of Research and Education

Vamsi Krishna Balla

Central Glass and Ceramic Research Institute

K.D.K. Luk

Chinese University of Hong Kong

William W. Lu

University of Hong Kong

Chuanxian Ding

Shanghai Institute of Ceramics

Cooperative Institutions

Chinese Academy of Sciences

Washington State University

Shanghai Institute of Ceramics

University of Chinese Academy of Sciences

Shougang Institute of Technology

Research Institute of Technology (Russia)

Chinese University of Hong Kong

University of Hong Kong

Central Glass and Ceramic Research Institute

Suzhou Institute of Nano-tech and Nano-bionics

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Plasma-sprayed diopside coatings for biomedical applications

Surface and Coatings Technology (2004)

Weichang Xue Xuanyong Liu Xuebin Zheng Chuanxian Ding

Diopside

Simulated body fluid

10.1016/j.surfcoat.2003.12.018

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Citations (57)

Processing and biocompatibility evaluation of laser processed porous titanium

Acta Biomaterialia (2007)

Weichang Xue B. Vamsi Krishna Amit Bandyopadhyay Susmita Bose

Biocompatibility

10.1016/j.actbio.2007.05.009

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Citations (442)

In vivo evaluation of plasma-sprayed titanium coating after alkali modification

Biomaterials (2004)

Weichang Xue Xuanyong Liu Xuebin Zheng Chuanxian Ding

Surface Modification

Titanium oxide

10.1016/j.biomaterials.2004.09.003

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Citations (91)

RF LDMOS with excellent robustness for wideband application

2015 Asia-Pacific Microwave Conference (APMC) (2015)

Zhengdong Liu Yuanxin Liu Dajie Zeng Weichang Xue Yaohui Zhang

A RF LDMOS with an additional P-type implant below channel region is presented to achieve high ruggedness. With the help of this implantation, the device shows significantly improved snapback performance. Besides on-wafer TLP test, we propose a more rigorous `open'-circuit test to demonstrate this fantastic robustness. The Faraday shield and drift region is finely engineered to achieve optimum Rds(on)-BV trade-off. A 1um-drift length device is shown to achieve more than 300mA/mm saturation current and 1.6W/mm power density at 1dB compression, while maintaining HCI immunity. A power amplifier is implemented from 400MHz to 470MHz to verify the broadband performance.

LDMOS

Robustness

Wideband

10.1109/apmc.2015.7413377

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Citations (1)

In vivo evaluation of plasma-sprayed wollastonite coating

Biomaterials (2004)

Weichang Xue Xuanyong Liu Xuebin Zheng Chuanxian Ding

Wollastonite

Biocompatibility

Bone tissue

10.1016/j.biomaterials.2004.09.027

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Citations (234)

In vivo evaluation of plasma sprayed hydroxyapatite coatings having different crystallinity

Biomaterials (2003)

Weichang Xue Shunyan Tao Xuanyong Liu Xuebin Zheng Chuanxian Ding

10.1016/s0142-9612(03)00545-3

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Citations (174)

Calcium Phosphate‐Based Resorbable Ceramics: Influence of MgO, ZnO, and SiO₂ Dopants

Journal of the American Ceramic Society (2006)

Amit Bandyopadhyay Sheldon A. Bernard Weichang Xue Susmita Bose

Resorbable calcium phosphate (CaP)‐based biomaterials are important because they can significantly improve health care by shortening the time necessary for restoration of functional loading of grafted bones. Although synthetic CaPs show exceptional similarities to natural bone, however, they are deficient in one major area, in that they do not have the same mineral content of bone. The focus of our work is to understand the influence of dopants on the physical, mechanical, and biological properties of tricalcium phosphate (TCP) resorbable ceramics with special emphasis toward in vitro strength degradation and cell–materials interactions as a function of time. For this purpose, β‐TCP was doped with magnesia (MgO), zinc oxide (ZnO), and silica (SiO 2 ). Those dopants were added as individual dopants, and their binary and ternary compositions. It was found that these dopants significantly influenced densification behavior and as sintered microstructures of TCP. In vitro mineralization studies in simulated body fluids (SBF) for 12 weeks showed apatite growth on the highly porous compositions either on the surface or inside. From scanning electron microscopic analysis it was evident that surface degradation occurred on all compositions in SBF. Compression strengths for samples up to 12 weeks in SBF showed that it is possible to tailor strength loss behavior through compositional modifications. The highest compression strength was found for binary MgO–ZnO doped TCP. Overall, samples showed either a similar strength level during the 12 weeks test period, or a continuous decrease or a continuous increase in strength depending on dopant chemistry or amount. In vitro human osteoblast cell culture was used to determine influence of dopants on cell‐materials interactions. All samples were non‐toxic and biocompatible. Dopant chemistry also influenced adhesion, proliferation, and differentiation of osteoblastic precursor cell line 1 (OPC1) cells on these matrices.

Simulated body fluid

10.1111/j.1551-2916.2006.01207.x

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Citations (221)

Polycaprolactone coated porous tricalcium phosphate scaffolds for controlled release of protein for tissue engineering

Journal of Biomedical Materials Research Part B Applied Biomaterials (2009)

Weichang Xue Amit Bandyopadhyay Susmita Bose

Abstract Polycaprolactone (PCL) was coated on porous tricalcium phosphate (TCP) scaffolds to achieve controlled protein delivery. Porous TCP scaffolds were fabricated using reticulated polyurethane foam as sacrificial scaffold with a porosity of 70–90 vol %. PCL was coated on sintered porous TCP scaffolds by dipping‐drying process. The compressive strength of TCP scaffolds increased significantly after PCL coating. The highest strength of 2.41 MPa at a porosity of 70% was obtained for the TCP scaffold coated with 5% PCL solution. Model protein bovine serum albumin (BSA) was encapsulated efficiently within the PCL coating. The amount of BSA encapsulation was controlled by varying proteins' composition in the PCL coating. The FTIR analysis confirmed that BSA retained its structural conformation and did not show significant denaturization during PCL coating. The release kinetics in phosphate buffer solution indicated that the protein release was controlled and sustained, and primarily dependant on protein concentration encapsulated in the PCL coating. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009

Polycaprolactone

Bovine serum albumin

10.1002/jbm.b.31464

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Citations (81)

Spherical and Anisotropic Hydroxyapatite Nanocrystals

Nanotechnologies for the Life Sciences (2009)

Susmita Bose Weichang Xue Ashis Banerjee Amit Bandyopadhyay

Abstract The sections in this article are Introduction Bone Structure Hydroxyapatite and its Crystal Structure Synthetic HA Nanocrystals: Application to Bone Replacement and Drug/Protein Delivery Bone Replacement Drug Delivery Synthesis of Hydroxyapatite Nanocrystals Wet Chemical Precipitation Sol–Gel Process Biomimetic Synthesis Hydrothermal Method Mechanochemical Powder Synthesis Solid‐State Reactions Microwave‐Assisted Synthesis Emulsion Process Surfactants Reverse Micelles Effect of Ageing Effect of Metal Ion Concentration Other Processes Characterization of Hydroxyapatite Nanocrystals Composition and Phase Analysis Nanoparticle Characterization for Size and Morphology Biological Characterization In Vitro Evaluation Methods: Simulated Body Fluids and Cell Culture In Vivo Animal Testing Toxicology of HA Nanoparticles Bulk Structures Using Hydroxyapatite Nanocrystals Microwave Sintering of Nanopowders Future Trends High‐Strength HA using Nano‐ HA and Dopants HA Scaffolds in Tissue Engineering Nanoscale HA Coatings for Load‐Bearing Implants HA in Drug/Protein Delivery

Characterization

10.1002/9783527610419.ntls0148

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Citations (2)

Functionally graded Co–Cr–Mo coating on Ti–6Al–4V alloy structures

Acta Biomaterialia (2007)

B. Vamsi Krishna Weichang Xue Susmita Bose Amit Bandyopadhyay

Biocompatibility

Titanium alloy

Brazing

10.1016/j.actbio.2007.10.005

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Citations (183)