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HF

Hiroaki Fukuzawa

Boston Children's Hospital

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Co-Authors

Tsutomu Chiba

Kyoto University

Shigeo Takaishi

Kyoto University

Hiroshi Seno

Kyoto University

Mitsutaka Sawada

Tokyo Medical and Dental University

Takahisa Kayahara

Kurashiki Central Hospital

Yukari Morita

Kochi Medical School Hospital

Hiroshi Hiai

Kyoto University

Yukari Morita-Fujisawa

Kyoto University

Katsumasa Suzuki

Tokyo City University

Hiroaki Kitagawa

St. Marianna University School of Medicine

Cooperative Institutions

Kyoto University

University of Sydney

St. Marianna University School of Medicine

Shizuoka Children's Hospital

Boston Children's Hospital

The University of Tokyo

Yokohama City Seibu Hospital

Weatherford College

Kurashiki Central Hospital

Kaiser Permanente

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Research Field

Growth promoting effect of thioredoxin on intestinal epithelial cells.

Digestive Diseases and Sciences (2003)

Shigeo Takaishi Mitsutaka Sawada Hiroshi Seno Takahisa Kayahara Yukari Morita-Fujisawa

Paneth cell

10.1023/a:1021952132241

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Citations (10)

Candidate markers for stem and early progenitor cells, Musashi‐1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine

FEBS Letters (2003)

Takahisa Kayahara Mitsutaka Sawada Shigeo Takaishi Hirokazu Fukui Hiroshi Seno

Musashi‐1, a neural RNA‐binding protein, is important for maintaining neural stem cells. Both Musashi‐1 and Hes1, a transcriptional factor regulated by Musashi‐1, are expressed in the small intestine. Here we show that Musashi‐1 is present in a few epithelial cells just above the Paneth cells in the small intestinal crypt, the putative position of stem cells, whereas Hes1 is expressed in lower crypt cells just above the Paneth cells, including Musashi‐1‐positive cells. Musashi‐1 and Hes1 were not expressed in Paneth cells. Notably, Musashi‐1 and Hes1 were coexpressed in the crypt base columnar cells located between the Paneth cells. These findings suggest that not only the cells just above Paneth cells but also the crypt base columnar cells between the Paneth cells have stem cell characteristics.

Paneth cell

HES1

10.1016/s0014-5793(02)03896-6

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Citations (290)

Relapse of unilateral favorable histology Wilms’ tumor: Significant clinicopathological factors

Journal of Pediatric Surgery (2012)

Takeshi Aoba Naoto Urushihara Koji Fukumoto Shigeyuki Furuta Hiroaki Fukuzawa

Histology

10.1016/j.jpedsurg.2012.09.010

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Citations (15)

The growth promoting effect of mammalian thioredoxin and the redox regulation of intestinal epithelial regeneration

Gastroenterology (2000)

Shigeo Takaishi Mitsutaka Sawada Yukari Morita Hiroaki Fukuzawa Hiroshi Seno

Parasitic Disease

Tropical disease

Paratenic

Identification

10.1016/s0016-5085(00)84546-1

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Citations (0)

Identification of granulocyte-macrophage colony stimulating factor in the rat paneth cells by singie cell RT-PCR technique and cDNA array

Gastroenterology (2001)

Hiroaki Fukuzawa Mitsutaka Sawada Shigeo Takaishi Hiroshi Seno Takahisa Kayahara

Identification

10.1016/s0016-5085(08)83472-5

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Enhanced expression of transforming growth factor (TGF) -alpha precursor and TGF-beta1 during Paneth cell regeneration.

Digestive Diseases and Sciences (2001)

Hiroshi Seno Mitsutaka Sawada Hiroaki Fukuzawa Yukari Morita Shigeo Takaishi

Dithizone

10.1023/a:1010797609041

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Citations (15)

Identification of GM-CSF in Paneth cells using single-cell RT-PCR

Biochemical and Biophysical Research Communications (2003)

Hiroaki Fukuzawa Mitsutaka Sawada Takahisa Kayahara Yukari Morita-Fujisawa Katsumasa Suzuki

Paneth cell

10.1016/j.bbrc.2003.11.009

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Citations (50)