Eric Simon

Hochschule Magdeburg-Stendal

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Olivier Joffre

Institut de Recherche en Gestion

Jacob M. Hiller

University of Massachusetts Amherst

Kenneth D. Carr

New York University

Yvon Pesqueux

Conservatoire National des Arts et Métiers

Li-Qun Fan

Neoleukin Therapeutics (United States)

Stanley M. Crain

Albert Einstein College of Medicine

Jean-Pierre Noblet

École Supérieure des Sciences Commerciales d’Angers

Toni D. Wolinsky

Porsolt (France)

Tara Finnigan

Albert Einstein College of Medicine

Elliot A. Stein

National Institute on Drug Abuse

Cooperative Institutions

New York University

Columbia University Irving Medical Center

École Polytechnique Fédérale de Lausanne

ETH Zurich

Brookhaven National Laboratory

Centre National de la Recherche Scientifique

Inserm

National Institutes of Health

Massachusetts Institute of Technology

Institut national de recherche en informatique et en automatique

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Les "vérités" du diagnostic d’entreprise

HAL (Le Centre pour la Communication Scientifique Directe) (2009)

Eric Simon Olivier Joffre

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No-carrier-added (NCA) (±)-N-(3-[18F]fluoropropyl)-N-normetazocine-Synthesis and PET studies in a baboon

International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology (1987)

Chyng‐Yann Shiue Ren‐Rui Teng Lan-Qin Bai Alfred P. Wolf Carroll D. Arnett

Radioligand

Radiosynthesis

Opiate

PET Imaging

Specific activity

Biodistribution

10.1016/0883-2897(87)90141-3

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Citations (3)

La RCG : un premier bilan

HAL (Le Centre pour la Communication Scientifique Directe) (2010)

Eric Simon Olivier Joffre

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Inhibition of AXL Receptor Tyrosine Kinase Enhances Brown Adipose Tissue Functionality in mice

Figshare (2023)

Vissarion Efthymiou Lianggong Ding Miroslav Baláž Wenfei Sun Lucia Balážová

Data above include all raw data used for the creation of the graphs in Main and Supplementary Figures 1-6, as well as all raw western blots for Main and Supplementary Figures 1-6.

GAS6

10.6084/m9.figshare.23092469

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Alterations in δ opioid receptor levels in discrete areas of the neocortex and in the globus pallidus of the aging guinea pig: a quantitative autoradiographic study

Brain Research (1993)

Jacob M. Hiller Li-Qun Fan Eric Simon

The effect of aging on delta opioid receptors was examined in the brains of guinea pigs aged 1, 6, 24 and 36 months. Quantitative autoradiography was used to monitor the concentrations of delta receptors in various anatomical regions at five rostro-caudal levels. delta opioid receptor populations were found to be remarkably stable throughout the life span of this species. We have, however, discovered anatomical areas which offer striking exceptions. In the globus pallidus, progressive age-related losses of delta receptors reached 50% in the senescent animal. In contrast, laminae I, II of the lateral agranular frontal cortex and laminae I, II and III, IV of the primary somatosensory cortex demonstrated age-related increases in the concentrations of delta receptors ranging from 30 to 45%. These changes are discussed with the view to their being functionally related components of motor circuitry involving pyramidal and extrapyramidal elements.

δ-opioid receptor

Neocortex

Senescence

10.1016/0006-8993(93)91021-j

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Development of tolerance to opiates and opioid peptides in organotypic cultures of mouse spinal cord

Life Sciences (1979)

Stanley M. Crain Bea Crain Tara Finnigan Eric Simon

Opiate

Drug tolerance

10.1016/0024-3205(79)90426-0

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Citations (33)

Neuroscience (1992)

Jacob M. Hiller Liqing Fan Eric Simon

Investigation into the effect of aging on kappa opioid receptors in the brains of guinea-pigs was carried out in animals aged one, six, 24 and 36 months. Quantitative autoradiography was used to monitor the concentration of kappa receptors in various anatomic regions at five rostrocaudal levels in each age-group. Areas of high binding were found in the deep layers (laminae V, VI) of the neocortex and in the internal band of the periallocortical, dorsal agranular insular cortex. Among non-cortical areas examined, the nucleus accumbens and the substantia nigra possessed kappa binding levels equal to those seen in the deep neocortical layers. In all cases where an age-related change in the level of kappa receptors was detected, the direction of the change was one of decreased binding with advancing age. Statistical analysis of the binding data revealed that the one-month-old animal possessed the highest levels of kappa binding among all age groups examined. The vast majority of age-related changes in kappa binding levels occurred in laminae V and VI of neocortical regions. The per cent decreases (18-42%), as well as their age of onset (six to 36 months) varied in different anatomical regions. Possible mechanisms to explain the age-related decreases in kappa opioid binding are presented. The majority of the age-related decreases in kappa opioid binding are found in areas of the neocortex which are characterized by their motor, sensory and associative functions. It is within these three areas of function that diminutions in performance are most apparent in senescence.

Neocortex

κ-opioid receptor

Kappa

10.1016/0306-4522(92)90455-b

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Citations (9)

Gesetzesauslegung im Strafrecht.

Strafrechtliche Abhandlungen (2005)

Eric Simon

Abstract Gegen die richterliche Praxis der Gesetzesauslegung wird nicht selten der Vorwurf der Beliebigkeit erhoben, i. d. R. ohne ausreichende Materialbasis.Eric Simon unternimmt es daher, den Stand der Rechtsprechung zur Methode der Normkonkretisierung für den Bereich der Strafrechts umfassend aufzubereiten. Aufgrund der dort geltenden Formenstrenge (Art. 103 II GG) ist dieses Rechtsgebiet als Prüfstein für methodisches Vorgehen besonders geeignet. Ausdrückliche wie implizite Stellungnahmen des BGH zu Methodenfragen werden systematisiert und auf Widersprüche hin untersucht. Dabei orientiert sich der Autor am klassischen Auslegungskanon und setzt Schwerpunkte bei der grammatikalischen und historischen Auslegung, da dort entscheidende Weichen gestellt werden (Auslegungsgrenze, subjektive/objektive Theorie). Über den Kanon hinaus wird nach Anhaltspunkten für eine von der Rechtsprechung bevorzugte Rangfolge der Auslegungskriterien gesucht. Einsichten der Methodenlehre fließen stets in die Urteilsanalysen ein. Insgesamt entsteht ein wertender Rückblick auf 50 Jahre Auslegungspraxis des BGH.Ausgezeichnet mit dem Forschungsförderpreis der Freunde der Uni Mainz e. V. 2005.

10.3790/978-3-428-51692-6

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Citations (4)

Cross-linking of human 125I-β-endorphin to a μ-θ opioid receptor complex in rat striatum

European Journal of Pharmacology (1989)

Anton N. M. Schoffelmeer Yi-He Yao Eric Simon

Ventral striatum

10.1016/0014-2999(89)90085-x

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Citations (9)

Opiate Receptors and Endorphins:

Advances in Alcohol & Substance Abuse (1982)

Eric Simon

This review presents a chronological discussion of the discovery of opiate receptors and the endogenous opioid peptides. After a summary of the properties and distribution of the receptors and their endogenous ligands, the possible function of the endogenous opioid system is discussed. Evidence for a role of this system in endogenous pain modulation and in opiate addiction is presented. The nature of the evidence and the absence of definitive proof of a causal involvement of the opiate receptor-endorphin system are emphasized.

Opiate receptors

Endorphins

Opiate

Endogenous opioid

10.1300/j251v01n01_03

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Citations (6)