Robert L. Becker

Center for Devices and Radiological Health

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Ulrika V. Mikel

Armed Forces Institute of Pathology

Timothy J. O’Leary

University of Maryland, College Park

Ian W. McLean

Armed Forces Institute of Pathology

Jason S. White

Carolina Urology Partners

Alison E. Director‐Myska

Defense Threat Reduction Agency

R. E. Fields

University of Wisconsin–Madison

Jeff McCurdy

University of Ottawa

Charles L. Hitchcock

The Ohio State University

J. Nath

West Virginia University

Stefan E. Pambuccian

Arizona State University

Cooperative Institutions

Armed Forces Institute of Pathology

National Cancer Institute

National Institutes of Health

Johns Hopkins University

United States Food and Drug Administration

Center for Drug Evaluation and Research

Armed Forces Institute of Pathology

Uniformed Services University of the Health Sciences

Harvard University

Walter Reed Army Institute of Research

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Development and regulatory strategies for drug and diagnostic co-development

Pharmacogenomics (2010)

Lois M. Hinman Kevin Carl Brian B. Spear Ronald A. Salerno Robert L. Becker

At the 5th FDA–Drug Industry Association (DIA) Workshop on 'Pharmacogenomics in Drug Development and Regulatory Decision Making', track four focused on the current thinking and issues in the co-development of therapeutic drugs or biologics, and their companion diagnostic products. Identification and validation of genomic and other biomarkers are becoming important components of drug-development strategies, and recent successes show the power of personalized approaches to change the benefit–risk paradigm for new drugs.

Pharmacogenomics

Drug Development

Identification

Regulatory Science

10.2217/pgs.10.141

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Citations (15)

Elastic scattering of 3.2 MeV neutrons from many elements

Nuclear Physics (1966)

Robert L. Becker William G. Guindon G.J. Smith

Nuclear cross section

Scattering cross-section

10.1016/0029-5582(66)90851-0

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Citations (40)

Total Cross Sections of Light Elements for (α, n) Neutrons

Physical Review (1956)

Robert L. Becker H. H. Barschall

The usefulness of the ${\mathrm{Be}}^{9}(\ensuremath{\alpha}, n)$ and the ${\mathrm{C}}^{13}(\ensuremath{\alpha}, n)$ reactions as sources of monoenergetic neutrons of variable energy was investigated. Measurements of the yield of the ${\mathrm{C}}^{13}(\ensuremath{\alpha}, n)$ reaction are presented. Total cross sections for elements of atomic number from 3 to 9 were measured for neutron energies between 4.4 and 5.6 Mev and between 7.6 and 8.6 Mev. The results give some information about energy levels in ${\mathrm{C}}^{13}$ and ${\mathrm{O}}^{17}$.

10.1103/physrev.102.1384

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Citations (32)

Cytometry and Morphometry of Malignant Fibrous Histiocytoma of the Extremities

The American Journal of Surgical Pathology (1991)

Robert L. Becker Ltcol David Venzon Ernest E. Lack Ulrika V. Mikel

Flow cytometry and nuclear morphometry were compared with traditional pathologic grading techniques for predicting the course of malignant fibrous histiocytoma of the extremities. Clinical, pathologic, and flow/morphometric variables from 53 cases were tested by Cox regression for prediction of distant recurrence and mortality. Tumor grading based on extent of tumor necrosis was a significant predictor for both disease-free survival (p = .014) and overall survival (p = .003). The fraction of nuclei in the S + G2M segment of DNA histograms was significant for disease-free survival (p = .007), and remained significant (p = .033) in a joint Cox model with necrosis-based grade (p = .004 for the bivariate model). Relative risk for recurrence varied nearly 10x between the 10th and 90th percentiles of grade and (S + G2M)1/2. Overall survival was predicted by a nuclear shape feature termed “R” (p = .000008), the casewise difference (residual) between expected and observed nuclear perimeter as a function of average Feret diameter. In a bivariate Cox model, relative risk of mortality varied 35x between the 10th and 90th percentiles of grade and R. Cytometric and morphometric data contain information about recurrence-free and overall survival beyond that available from more usual clinical and pathologic features. It seems likely that nuclear morphometry, in particular, will prove to be a useful aid for estimating the prognosis of patients with malignant fibrous histiocytoma of the extremities.

Grading (engineering)

10.1097/00000478-199110000-00006

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Citations (30)

Pulmonary nodules resembling bronchioloalveolar carcinoma in adolescent cancer patients.

PubMed (1988)

William D. Travis R. Ilona Linnoila M. Horowitz Robert L. Becker Harvey I. Pass

Carcinoembryonic antigen

Solitary pulmonary nodule

Nodule (geology)

Source

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Citations (27)

Comparison of in-vivo skin models for near-infrared laser exposure

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (1999)

Thomas A. Eggleston Michael A. Mitchell Thomas E. Johnson Robert L. Becker William P. Roach

Current safety standards for lasers operating in the 1400 to 10,000 nm wavelength region are based on few observations at specific wavelengths using in vivo models that may not represent an accurate correlation to human integument. Based on experimental results conducted with Yorkshire pigs, these standards may not accurately reflect the potential for laser injury when humans are exposed to these wavelengths. It is our belief that one of the primary damage mechanisms involved in these laser injuries is due to energy absorption by skin pigmentation, or melanin. Qualitatively, Yorkshire pigs lack melanin in their skin when compared to a more highly pigmented animal, such as the Yucatan minipig. It is hypothesized that the Yucatan minipig is a more appropriate model for pigmented human skin. By comparing histologic samples taken from various locations on Yucatan minipigs and Yorkshire pigs, and comparing these to potential locations of skin exposure on humans, we present a discussion for the establishment of more appropriate locations for in vivo laser exposure studies.

Human skin

Animal model

Integument

10.1117/12.350981

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Citations (1)

Total Fast Neutron Cross Sections of Co, Ga, Se, Cd, Te, Pt, Au, Hg, and Th

Physical Review (1953)

M. Walt Robert L. Becker A. Okazaki R. E. Fields

The total neutron cross sections of Co, Ga, Se, Cd, Te, Pt, Au, Hg, and Th were measured as a function of neutron energy from 0.1 to 3 Mev. An estimate of the error caused by neutrons scattered into the detector was made by measuring the apparent cross section as a function of sample diameter. The results give additional evidence that, neglecting resonance structure, total structure, total neutron cross-section curves have characteristic shapes which change slowly with atomic weight.

10.1103/physrev.89.1271

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Citations (33)

Morphometric Distinction of Sclerosing Adenosis from Tubular Carcinoma of the Breast

Pathology - Research and Practice (1992)

Robert L. Becker Ulrika V. Mikel Timothy J. O’Leary

Discriminant function analysis

Breast carcinoma

10.1016/s0344-0338(11)80242-6

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Citations (13)

Charged particle discrimination in a CsI(T1) detector

Nuclear Instruments and Methods (1961)

J. A. Biggerstaff Robert L. Becker M. T. McEllistrem

Alpha particle

α particles

Particle (ecology)

10.1016/s0029-554x(61)80127-4

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Citations (28)

DNA Analysis of cardiac myxomas: Flow cytometry and image analysis

Human Pathology (1991)

Jeffrey D. Seidman Jules J. Berman Charles L. Hitchcock Robert L. Becker Wolfgang J. Mergner

Cardiac myxoma is the most common primary tumor of heart, but there is a longstanding controversy over whether it is a true neoplasm or a reactive lesion. We analyzed 24 cardiac myxomas from 22 patients: 22 by DNA flow cytometry and five by image analysis. Two myxomas were aneuploid; one of those analyzed by flow cytometry, and the other by image analysis. Proliferative fractions (S + G2/M) were high in three tumors from patients with multiple myxomas (mean, 15.9%; SD, 4.0%) as compared with 12 solitary uncomplicated myxomas (mean, 7.7%; SD, 6.0%). S-phase and proliferative fractions were low in embolic, recurrent, and solitary myxomas. The presence of aneuploidy in some myxomas supports a neoplastic origin for this tumor.

10.1016/0046-8177(91)90137-e

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Citations (22)