Yu Yan

Affiliated Hospital of Southwest Medical University

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Guofu Hou

Nankai University

Zhiyuan Xu

Jinan University

Yaya Song

Nankai University

Xiaodan Zhang

Nankai University

Ying Lu

Guangxi University

Wenzheng Shi

Shanghai Ocean University

Ying Zhao

Jiangsu Normal University

Roeland Van Wijk

Leiden University

Qian Huang

Nankai University

Jingxiang Pang

Shandong First Medical University

Cooperative Institutions

Chinese Academy of Sciences

Nankai University

Collaborative Innovation Center of Chemical Science and Engineering Tianjin

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Jiao Tong University

Central South University

Pfizer (United States)

Nanjing University

University of Chinese Academy of Sciences

Sichuan University

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Research Field

OPTM dataset

Zenodo (CERN European Organization for Nuclear Research) (2023)

Yu Yan

Oxidative PTM dataset for MIND-S

10.5281/zenodo.7655827

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Multiple Proteins Interact with the fushi tarazu Proximal Enhancer†

Molecular and Cellular Biology (1993)

Wei Han Yu Yan Nihal Altan Leslie Pick

The expression of the Drosophila segmentation gene fushi tarazu (ftz) is controlled at the level of transcription. The proximal enhancer, located approximately 3.4 kb upstream of the transcription start site, directs lacZ fusion gene expression in a ftz-like seven-stripe pattern in transgenic fly embryos. We have taken a biochemical approach to identify DNA-binding proteins that regulate ftz gene expression through the proximal enhancer. DNase I footprinting and methylation interference experiments with staged Drosophila embryo nuclear extracts identified nine protein binding sites in the proximal enhancer. Ten different sequence-specific DNA-binding complexes that interact with eight of these sites were identified. Some interact with multiple sites, while others bind to single sites in the enhancer. Two of the complexes that interact with multiple sites appear to contain the previously described ftz regulators, FTZ-F1 and TTK/FTZ-F2. These in vitro studies allowed us to narrow down the proximal enhancer to a 323-bp DNA fragment that contains all of the protein binding sites. Expression directed by this minimal enhancer element in seven ftz-like stripes in transgenic embryos is identical to that directed by the full-length enhancer. Internal deletions of several sites abolish reporter gene expression in vivo. Thus, the ftz proximal enhancer, like other cell-type-specific eukaryotic enhancers, interacts with an array of proteins that are expected to mediate the establishment, maintenance, and repression of transcription of the ftz gene in seven stripes in the developing embryo.

Enhancer trap

Enhancer RNAs

Transcription

10.1128/mcb.13.9.5549-5559.1993

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Citations (14)

The safety analysis of live working on 500/220kV four-parallel lines on the same tower

Qi Yang Dehua Zou C.S. Tong Zengming Xia Yu Yan

With obvious economic and social benefits, fourparallel lines on the same tower is widely used and has high reliability requirements, the use of live working to carry out maintenance is particularly important. This paper takes 500/220kV four-parallel lines on the same tower as the research object. First, through the analysis of the risk of 500kV and 220kV line typical operation position, it can be found that the typical location operation risk is less than 1.0×10 ^-5 , and the workers can safely work. Secondly, the body surface field strength distribution of live working worker under the condition of equal potential is obtained by using the finite element method to calculate and analyze. The calculation shows that the strength of each part of the worker in 220 kV transmission line is obviously larger than that of 500kV lines, the strength of the worker's feet reachs a maximum of 2138kV/m, but the field strength inside the shielding clothes would be limited to the safe range when the workers put on shielding efficiency greater than 43.08dB. Therefore, by taking appropriate measures, the workers can safely carry out live working on the 500/220kV line.

Line (geometry)

Field strength

Parallel

10.1109/icpre.2016.7871120

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Citations (2)

Apoptotic induction by mdm2 siRNA on human colorectal carcinoma cell lines LoVo

Harbin Yike Daxue xuebao (2006)

Yu Yan

Objective To investigate the effect of mdm2 Small interfering RNA(siRNA) on apoptosis in human colorectal carcinoma cell lines LoVo cells.Methods LoVo cells were transfected with mdm2 siRNA.RT-PCR and Western blot analysis of mdm2 mRNA and protein expression in LoVo cells.Growth curve,Flowcytometry,TUNEL assay and MTT colorimetry were used for determination of apoptosis in LoVo cells.Results Transfection of LoVo cells with mdm2 siRNA significantly inhibited MDM2 expression at both mRNA and protein level in LoVo cells;treatment of LoVo cells with mdm2 siRNA resulted in growth inhibition;this significantly increased apoptotic cell rate.mdm2 siRNA had an effect on induction of either early or late stage apoptosis.We also found that when combined with DDP,mdm2 siRNA significantly inhibited tumor growth with reductions in tumor cells compared with that seen with mdm2 siRNA.Conclusion Mdm2 siRNA effectively inhibits mdm2 gene expression in LoVo cells and leads to induction of apoptosis in LoVo cells.And it also enhances the sensitivity to DDP.The use of mdm2 siRNA technique may provide a novel therapeutic approach to treat tumors.

MTT assay

Growth inhibition

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Drift current induced tunable spin current in inverted-graphene based spin valve

Carbon (2025)

Jian Zhou Xianyang Lu Bing Zhao Jiaju Yang Yu Yan

Spin valve

Spin Current

10.1016/j.carbon.2025.120140

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Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol: Erratum

International Journal of Biological Sciences (2024)

Yucai Chen Tianyi Yuan Huifang Zhang Yu Yan Danshu Wang

[This corrects the article DOI: 10.7150/ijbs.20316.].

10.7150/ijbs.96249

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BCL6 overexpression in CD4+ T cells induces Tfh-like transdifferentiation and enhances antitumor efficiency of CAR-T therapy in pancreatic cancer

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2024)

Xuan Lin Zhengjie Dai Yesiboli Tasiheng Rulin Zhang Ruijie Wang

PDAC is a typical "cold tumor" characterized by low immune cell infiltration and a suppressive immune microenvironment. We previously observed the existence of a rare group of follicular helper T cells (Tfh) that could enhance antitumor immune responses by recruiting other immune cells in PDAC. In this study, we ectopically expressed BCL6 in CD4

Transdifferentiation

BCL6

10.1016/j.bbadis.2024.167346

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Citations (1)

One-Pot Synthesis of 1,4-Bridged Dihydroisoquinoline-3-ones from Isoquinolinium Salts and Cyclic 1,3-Diketones

Acta Chimica Sinica (2022)

Yin Yucheng Li‐Jing Leng Lin Xiaolong Yu Yan Tian Cai

余燕蔡甜罗群力 * (西南大学化学化工学院重庆市应用化学重点实验室重庆 400715) 摘要异喹啉盐具有两个亲电位点, 用它与双亲核试剂发生去芳构化/环化反应, 是高效构建异喹啉桥环结构的有效策略

10.6023/a22090408

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Citations (2)

Self‐Diffusion Effect Assisted TiO₂/Li₃PO₄ Electron Selective Passivating Contact in Silicon Solar Cells Approaching 23% Efficiency

Small (2024)

Zhiyuan Xu Yu Yan Wei Li Qianfeng Gao Yaya Song

Carrier selective contacts with passivation effects are considered to have a significant influence on the performance of crystalline silicon (c-Si) solar cells. It is essential for electron selective contact materials to meet the requirements of ultra-low contact resistance and excellent passivation effects. This work introduces a stack layer of Lithium Phosphate (Li

Passivation

Contact resistance

Carrier lifetime

10.1002/smll.202407398

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Phylogeneticanalysis of Maf Gene Family

Ludong University Journal (2014)

Yu Yan

Maf family proteins are a large number of transcriptional factors which include a characteristic basic region and a leucine zipper( b-Zip) motif. They play key roles in the hemacytopoiesis,pancreatic differentiation,and the lens development of eyes. However,the evolutionary process of Maf gene family is unknown. In this study,genome-wide survey of Maf gene family was performed,and chromosome location,gene structure,conserved protein motifs of Mafs were analyzed. To explore the evolution of Maf gene family with the struction of phylogenetic tree.

Motif (music)

Protein family

Conserved sequence

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