Michael E. Phelps

University of California, Los Angeles

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Johannes Czernin

University of California, Los Angeles

Heinrich R. Schelbert

University of California, Los Angeles

Sung‐Cheng Huang

University of California, Los Angeles

David E. Kuhl

Canadian Blood Services

Jorge R. Barrio

University of California, Los Angeles

Daniel Silverman

Howard Hughes Medical Institute

John C. Mazziotta

University of California, Los Angeles

Nagichettiar Satyamurthy

Oslo University Hospital

Edward J. Hoffman

University of Pittsburgh

Simon R. Cherry

University of California, Davis

Cooperative Institutions

University of California, Los Angeles

361

UCLA Health

UCLA Medical Center

Institute for Molecular Medicine

UCLA Jonsson Comprehensive Cancer Center

Harvard University

Memorial Sloan Kettering Cancer Center

Los Angeles Medical Center

University of California, San Francisco

Ronald Reagan UCLA Medical Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Biological imaging and the molecular basis of dopaminergic diseases

Biochemical Pharmacology (1997)

Jorge R. Barrio Sung C. Huang Michael E. Phelps

MPTP

10.1016/s0006-2952(97)00031-2

Cite

Citations (55)

A tabulated summary of the FDG PET literature.

PubMed (2002)

Sahil Gambhir Johannes Czernin Judy Schwimmer Daniel Silverman R. Edward Coleman

TO THE EDITOR: We read and re-read your outstanding supplement titled “A Tabulated Summary of the FDG PET Literature” ([1][1]). It helps take the world literature and put it in perspective. This has already helped us discuss the pros and cons of PET imaging in pancreatic carcinoma with a

PET Imaging

Source

Cite

Citations (942)

Local cerebral metabolism during partial seizures

Neurology (1983)

Jerome Engel David E. Kuhl Michael E. Phelps Rebecca Rausch Marc R. Nuwer

Intericta1 and ictal fluorodeoxyglucose scans were obtained with positron CT from four patients with spontaneous recurrent partial seizures, one with epilepsia partialis continua, and one with a single partial seizure induced by electrical stimulation of the hippocampus. Ictal metabolic patterns were different for each patient studied. Focal and generalized increased and decreased metabolism were observed. Ictal hypermetabolism may exceed six times the interictal rate and could represent activation of excitatory or inhibitory synapses in the epileptogenic region and its projection fields. Hypometabolism seen on ictal scans most likely reflects postictal depression and may indicate projection fields of inhibited neurons. No quantitative relationship between alterations in metabolism and EEG or behavioral measurements of ictal events could be demonstrated.

Hypermetabolism

Epilepsia partialis continua

Complex partial seizures

10.1212/wnl.33.4.400

Cite

Citations (206)

Positron Emission Tomography: Human Brain Function and Biochemistry

Science (1985)

Michael E. Phelps John C. Mazziotta

Positron emission tomography (PET) is an analytical imaging technique that provides a way of making in vivo measurements of the anatomical distribution and rates of specific biochemical reactions. This ability of PET to measure and image dynamic biochemistry builds a bridge between the basic and clinical neurosciences founded on the commonality of the types of measurements made. Clinical findings with PET in humans are suggesting hypotheses that can be tested rigorously in the basic science laboratory.

Brain Function

PET Imaging

10.1126/science.2860723

Cite

Citations (469)

Additional file 1: Figure S1

Mark Lazari Kevin M. Quinn Shane B. Claggett Jeffrey J. Collins Gaurav J. Shah

Source

Cite

Citations (0)

KINETIC STUDIES OF HUMAN BRAIN TUMORS WITH POSITRON COMPUTED TOMOGRAPHY (PCT)

Clinical Nuclear Medicine (1984)

Randall A. Hawkina Michael E. Phelps Sung‐Cheng Huang Joseph Wapenski Allan W. Silberman

We studied 9 patients with primary and metastatic brain tumors with PCT. All subjects had kinetic F-18 fluorodeoxyglucose (FDG) studies. A modified version of the FDG model permitted estimates of the rate constants k1*, k2*, k3* and k4* as well as a fifth parameter representing cerebral blood volume (CBV). 6 subjects had CBF studies with 0–15 water, 4 subjects had CBV studies with 0–15 CO and 3 subjects had BBB kinetic studies the Ga-68 EDTA. Estimated values of CBV determined kinetically with FDG averaged 6.09 (± 1.35)cc/100gm in tumors compared to 7.47 (± 2.60)cc/100gm measured directly with 0–15 CO. The ratio of the relative CBV (determined kinetically with FDG versus directly with CO) in gray matter and tumors (compared to global values) averaged 1.02 (± 0.18) in these same 4 subjects. Simulation studies on the impact of CBV upon glucose metabolic rates (CMRG1c) determined with FDG indicated a larger overestimation of CMRG1c as CBV increased. The estimated CMRG1c determined with and without a CBV correction approached the same value in the actual patient studies as CBV decreased, in agreement with the simulation results. CBF and CMRG1c measurements together permitted calculation of net glucose extraction (GER). We found an inverse relationship between CBF and GER. Quantitative estimates of BBB permeability demonstrated no dramatic change in FDG rate constants as a function of BBB permeability changes. These studies indicate: 1) kinetic estimates of CBV in tumor and normal tissue is possible with FDG and 2) the relationships between CBF, GER and BBB permeability is quantifiable in human tumors with PCT.

10.1097/00003072-198409001-00011

Cite

Citations (0)

Data from 18F-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers

Nicolaos Palaskas Steven M. Larson Nikolaus Schultz Evangelia Komisopoulou Justin Wong

<div>AbstractIn contrast to normal cells, cancer cells avidly take up glucose and metabolize it to lactate even when oxygen is abundant, a phenomenon referred to as the Warburg effect. This fundamental alteration in glucose metabolism in cancer cells enables their specific detection by positron emission tomography (PET) following i.v. injection of the glucose analogue 18F-fluorodeoxy-glucose (18FDG). However, this useful imaging technique is limited by the fact that not all cancers avidly take up FDG. To identify molecular determinants of 18FDG retention, we interrogated the transcriptomes of human-cancer cell lines and primary tumors for metabolic pathways associated with 18FDG radiotracer uptake. From ninety-five metabolic pathways that were interrogated, the glycolysis, and several glycolysis-related pathways (pentose phosphate, carbon fixation, aminoacyl-tRNA biosynthesis, one-carbon-pool by folate) showed the greatest transcriptional enrichment. This “FDG signature” predicted FDG uptake in breast cancer cell lines and overlapped with established gene expression signatures for the “basal-like” breast cancer subtype and MYC-induced tumorigenesis in mice. Human breast cancers with nuclear MYC staining and high RNA expression of MYC target genes showed high 18FDG-PET uptake (P < 0.005). Presence of the FDG signature was similarly associated with MYC gene copy gain, increased MYC transcript levels, and elevated expression of metabolic MYC target genes in a human breast cancer genomic dataset. Together, our findings link clinical observations of glucose uptake with a pathologic and molecular subtype of human breast cancer. Furthermore, they suggest related approaches to derive molecular determinants of radiotracer retention for other PET-imaging probes. Cancer Res; 71(15); 5164–74. ©2011 AACR.</div>

Basal (medicine)

10.1158/0008-5472.c.6502157.v1

Cite

Citations (0)

Impact of 18F-FDG PET on managing patients with colorectal cancer: the referring physician's perspective.

PubMed (2001)

Joubin Meta Marc Seltzer C Schiepers Daniel Silverman Maryam Ariannejad

Whole-body PET imaging with 18F-FDG has been used successfully to stage colorectal cancer. However, the impact of FDG PET on patient management from the referring physician's point of view has not been determined.A questionnaire was sent to referring physicians to determine whether and how PET altered the management of colorectal cancer patients. Management changes, when present, were classified as intermodality (e.g., medical to surgical, surgical to radiation, medical to no treatment) or intramodality (e.g., altered medical, surgical, or radiotherapy approach).Of 60 responses from referring physicians, changes in clinical stage were reported for 25 patients (42%). Among these, the disease was upstaged in 20 patients (80%) and downstaged in 5 patients (20%). The PET findings contributed to intermodality management changes in 22 of the 60 patients (37%), intramodality changes in 11 patients (18%), a combination of management changes in 4 patients (7%), and no change in 19 patients (32%). Two of the 60 patients (3%) had other changes, and no response to this question was received for the remaining 2 patients (3%). As a result of PET findings, physicians avoided major surgery in 41% of patients for whom surgery was the intended treatment.This survey-based study of referring physicians shows that FDG PET had a major impact on the management of colorectal cancer patients and contributed to changes in clinical stage and major management decisions in >40% of patients.

Source

Cite

Citations (122)

Comprar Physics in Nuclear Medicine, 4th Edition | Michael E. Phelps | 9781416051985 | Saunders

Michael E. Phelps Simon R. Cherry

Tienda online donde Comprar Physics in Nuclear Medicine, 4th Edition al precio 103,94 € de Michael E. Phelps | Simon R. Cherry, tienda de Libros de Medicina, Libros de Radiologia - Medicina Nuclear

Nuclear medicine imaging

Source

Cite

Citations (0)

Oral18F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: Demonstration of principle

American Journal of Primatology (1997)

Zoe Allen Martinez Mark Colgan Lewis R. Baxter Javier Quintana Stefan Siegel

We describe a method of orally administering 18F-fluoro-2-deoxyglucose (FDG) for positron emission tomography (PET) scans to determine local cerebral metabolic rates for glucose (LCMRGlc), normalized to that of whole brain, in fully conscious, non-restrained primates. Oral FDG-PET studies were performed in both non-restrained and chaired monkeys, and in one human where results could be compared with traditional intravenous FDG administration. The oral route of FDG administration gave images and whole brain-normalized PET LCMRGlc results comparable to those obtained by the intravenous route. This oral FDG-PET method may provide a useful means by which to obtain measures of LCMRGlcs for brain structures, relative to each other, in non-restrained, non-drugged primates in field and laboratory studies. This method might also have clinical applications for PET studies of children.

Deoxyglucose

10.1002/(sici)1098-2345(1997)42:3<215::aid-ajp4>3.0.co;2-

Cite

Citations (14)