Janine A. Smith

Sydney Children’s Hospitals Network

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Robert B. Nussenblatt

National Eye Institute

Scott M. Whitcup

Doheny Eye Institute

Charles E. Egwuagu

National Institutes of Health

Kelly K. Nichols

University of Alabama at Birmingham

Chi‐Chao Chan

National Institutes of Health

Grace A. Levy-Clarke

West Virginia University

Ronald Buggage

Sanofi (France)

Gary N. Foulks

University of Louisville

Stanley R. Pillemer

MacroGenics (United States)

Michael E. Stern

Cornell University

Cooperative Institutions

National Institutes of Health

National Eye Institute

Ophthalmology Associates (United States)

Harvard University

National Cancer Institute

Research to Prevent Blindness

Johns Hopkins University

Massachusetts Eye and Ear Infirmary

University of Illinois Chicago

Smith-Kettlewell Eye Research Institute

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(CL-231)DRY EYE DIAGNOSTIC TESTS AND SURVEYS: PERFORMANCE AND ASSOCIATION

Optometry and Vision Science (2000)

Kelly K. Nichols Janine A. Smith

1Ohio State University, College of Optometry, Columbus, OH; 2The National Eye Institute, National Institutes of Health, Bethesda, MD.

Association (psychology)

10.1097/00006324-200012001-00006

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Citations (0)

Keratitis caused by candida glabrata in a patient with chronic granulomatous disease

American Journal of Ophthalmology (2001)

Ali R. Djalilian Janine A. Smith Thomas J. Walsh Harry L. Malech Michael R. Robinson

Candida glabrata

Chronic Granulomatous Disease

Fungal Keratitis

10.1016/s0002-9394(01)01091-1

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Citations (28)

Current Patterns in the Use of Diagnostic Tests in Dry Eye Evaluation

Cornea (2008)

Janine A. Smith Kelly K. Nichols Edward K Baldwin

Purpose: To clarify the roles of objective signs and subjective symptoms in the diagnosis and management of dry eye by describing their use by a group of expert practitioners. Dry eye signs and symptoms do not always correlate well, and there is currently some controversy over the ideal roles of signs and symptoms and their actual use in clinical practice. Methods: A balanced panel of 16 participants in a scientific roundtable on dry eye reviewed 4 patient case studies and completed surveys ranking common diagnostic procedures assessing symptoms and signs by the order in which they would be used. Results: Symptom assessment was the predominant diagnostic method. The objective tests most commonly used during the initial examination were tear breakup time (93%), corneal staining (85%), tear film assessment (76%), conjunctival staining (74%), and the Schirmer test (54%). Most panelists used multiple tests, with a median of 6 tests used in the initial examination. Conclusions: Subjective symptoms and objective signs are both important in the diagnosis and management of dry eye, with the patient's symptoms and history playing a critical role. Most clinicians use objective signs in dry eye management. However, currently available diagnostic tests do not correlate reliably with symptom severity. Research aimed at developing accurate, objective, responsive measures of dry eye severity is needed.

Signs and symptoms

Artificial tears

10.1097/01.ico.0000611384.81547.8d

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Citations (60)

The Ocular Complications of Smallpox and Smallpox Immunization

Archives of Ophthalmology (2004)

Janine A. Smith

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Ophthalmology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Ophthalmology journal

10.1001/archopht.122.9.1407-a

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Citations (5)

What Leads to Dryness?

Janine A. Smith MD Serena Morrison

Abstract Sjogren’s Syndrome affects the exocrine glands, which produce saliva and tears. Two of the key features of Sjogren’s syndrome are dry eye (also called keratoconjunctivitis sicca or KCS) and dry mouth (also called xerostomia). What is the cause of this dryness? In this chapter, the normal function and disease-related dysfunction of the lacrimal and salivary glands affected in Sjogren’s syndrome will be discussed. Then theories about the cause of the dryness will be considered.

Dryness

KERATOCONJUNCTIVITIS SICCA

Dry mouth

Xerophthalmia

Schirmer test

Exocrine gland

Sicca syndrome

Sjögren syndrome

Lacrimal apparatus

Keratoconjunctivitis

10.1093/oso/9780195172287.003.0004

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Citations (0)

Maintenance of water balance in the twice-stabbed ladybird beetle,Chilocorus cacti(Coleoptera: Coccinellidae), despite heavy infestation by the mite,Hemisarcoptes cooremani(Acari: Acariformes)

International Journal of Acarology (1999)

Jay A. Yoder Marilyn A. Houck Burel R. Goodin Janine A. Smith

Abstract Large numbers (up to 400/elytron) of heavily sclerotized deutonymphs of the mite, Hemisarcoptes cooremani, attach to the elytral hypodermis of desert-inhabiting beetles, Chilocorus cacti, for transport and feeding. A potential physiological benefit to beetles of tolerating attached mites in dry habitats may be a reduction of the surface area-to-volume ratio of exposed evaporatory tissue (decreased water loss), especially during flight. In this study, infested beetles were observed to have identical water balance characteristics as nonparasitized beetles, indicating that mites provide no extra, mechanical advantage to the beetle in terms of increased water conservation. The beetles were not distinguished by having a low water content, high tolerance for dehydration, or ability to absorb water vapor from the atmosphere. Their ability to retain water (low net water loss rate that compares favorably to values for diapausing beetles that maximize water conservation during quiescence), however, helps adapt them to a dry environment, supports the behavior of reflex bleeding, and probably aids in the toleration of their interaction with Hemisarcoptes.

10.1080/01647959908684172

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Citations (4)

Therapeutic potential of CDK5 inhibitors to promote corneal epithelial wound healing

Expert Opinion on Therapeutic Patents (2005)

Peggy S. Zelenka Janine A. Smith

AbstractCyclin-dependent kinase 5 (CDK5) is generally considered to be a neuron-specific enzyme, and CDK5 inhibitors have most often been claimed for pharmacologic use in neurodegenerative diseases. However, recent findings indicate that CDK5 also has important functions in some non-neuronal cells, where it regulates such processes as differentiation, senescence, adhesion and migration. In particular, CDK5 activity has been shown to increase adhesion and decrease migration of corneal epithelial cells, both in vitro and in transgenic mouse models. Conversely, inhibition of CDK5 activity significantly enhances closure of corneal epithelial defects, suggesting a novel therapeutic use for CDK5 inhibitors. This review evaluates the therapeutic potential of currently available CDK5 inhibitors for this application and considers the types of corneal epithelial defects that may benefit from such treatment.Keywords:: corneacyclin-dependent kinasediabetic keratopathyepitheliuminfectious keratitisneurotrophic keratopathywound healing

Cyclin-dependent kinase 5

10.1517/13543776.15.7.875

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Citations (4)

A randomized, placebo‐controlled, double‐masked clinical trial of etanercept for the treatment of uveitis associated with juvenile idiopathic arthritis

Arthritis Care & Research (2005)

Janine A. Smith Darby J. S. Thompson Scott M. Whitcup Eric B. Suhler Grace Clarke

To investigate the safety and efficacy of etanercept in the treatment of uveitis associated with juvenile idiopathic arthritis (JIA).Children who met the American College of Rheumatology diagnostic criteria for JIA with active uveitis, who had anterior chamber cells of >/=1+ or requiring topical corticosteroid >/=3 times daily, and who were on a stable regimen for arthritis treatment were eligible. Study participants received etanercept (0.4 mg/kg) or placebo administered subcutaneously twice weekly for 6 months. All participants received open-label etanercept for an additional 6 months.Five patients received placebo and 7 received etanercept. Three of the 7 patients treated with etanercept and 2 of the 5 placebo-treated patients were considered ophthalmic successes (P = 1.0). One patient in each treatment group was considered a treatment failure. Three of the 7 etanercept-treated and 2 of the 5 placebo-treated patients were neither successes nor failures by our definition. There were no serious adverse events for any patient during the entire study period. Reports of minor infections were comparable in each treatment group, 71% for etanercept and 60% for placebo (P = 0.58).In this small pilot study there was no apparent difference in the anterior segment inflammation between patients treated with etanercept and placebo. The stringent criteria used to measure ophthalmic success of treatment and the small patient population limit the implications of our findings.

Regimen

10.1002/art.20904

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Citations (306)

Intraocular Levels of Methotrexate After Intravenous Administration

American Journal of Ophthalmology (1996)

Marc D. de Smet Virginia Stark-Vanes David Köhler Janine A. Smith Robert E. Wittes

10.1016/s0002-9394(14)70444-1

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Citations (52)

Hypergammaglobulinemia and Corneal Opacities in Patients with Human T-Cell Lymphotrophic Virus Type–1

American Journal of Ophthalmology (2006)