Michael Pape

Medizinische Hochschule Hannover

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Hans J. Hedrich

Medizinische Hochschule Hannover

G. Flatz

Chiang Mai University

Marion Laig

Thermo Fisher Scientific (United States)

J. Hundrieser

Medizinische Hochschule Hannover

C.-M. Prokop

Medizinische Hochschule Hannover

Barnali Das

Gauhati University

Torpong Sanguansermsri

University of Phayao

Wolf‐Dieter Ludwig

Charité - Universitätsmedizin Berlin

Norbert Bornfeld

National Center for Tumor Diseases

Naret Mularlee

Khon Kaen University

Cooperative Institutions

Medizinische Hochschule Hannover

Humboldt-Universität zu Berlin

Freie Universität Berlin

Chiang Mai University

Charité - Universitätsmedizin Berlin

University of Duisburg-Essen

Essen University Hospital

Ophthalmology Clinic

Universitätsklinik für Augenheilkunde

University of Veterinary Medicine Hannover, Foundation

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Localization of the Pfkfb 2 gene on rat Chromosome 13

Mammalian Genome (1996)

Michael Pape C.-M. Prokop Hans J. Hedrich

Human genetics

10.1007/s003359900288

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Citations (3)

Assessment of genomic instability in breast cancer and uveal melanoma by random amplified polymorphic DNA analysis

International Journal of Cancer (2002)

Sarantos Papadopoulos T. Benter Gerasimos Anastassiou Michael Pape Gerhard Schäller

Abstract Some types of cancer have been associated with abnormal DNA fingerprinting. We used random amplified polymorphic DNA (RAPD) to generate fingerprints that detect genomic alterations in human breast cancer. Primers were designed by choosing sequences involved in the development of DNA mutations. Seventeen primers in 44 different combinations were used to screen a total of 6 breast cancer DNA/normal DNA pairs and 6 uveal melanoma DNA/normal DNA pairs. Forty‐five percent of these combinations reliably detected quantitative differences in the breast cancer pairs, while only 18% of these combinations detected differences in the uveal melanoma pairs. Fourteen (32%) and 12 (27%) primers generated a smear or did not produce any band patterns in the first and second cases, respectively. Taking into account the ability of RAPD to screen the whole genome, our results suggest that the genomic damage in breast cancer is significantly higher than in uveal melanoma. Our study confirms other reports that the molecular karyotypes produced with random priming, called amplotypes, are very useful for assessing genomic damage in cancer. © 2002 Wiley‐Liss, Inc.

genomic DNA

DNA profiling

10.1002/ijc.10297

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Citations (44)

The distribution of the Hb Constant Spring gene in Southeast Asian populations

Human Genetics (1990)

Marion Laig Michael Pape J. Hundrieser G. Flatz Torpong Sanguansermsri

10.1007/bf00208939

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Citations (58)

Mediterranean types of ?-thalassemia in the German population