bleed glucose concentration, and serum insulin levEl, and no chnnge of }]lasma glucagun level.Thc vattern of these parameters changes between before and after ergometer eNercise showed no
In order to investigate the antianginal effects of celiprolol (NBP-582), a randomized double-blind crossover study controlled with placebo was carried out in 17 patients with stable effort angina pectoris. Multistage treadmill exercise testing was performed before and at 4, 7, and 24 hr after a single oral administration of 400mg celiprolol or placebo. The exercise testing was terminated at moderate angina pain.The treadmill exercise duration showed no statistically significant time effects or order effects either before or after administration of the test drugs.Celiprolol significantly prolonged exercise duration, time to angina, and time to onset of ST-segment depression≥0.1mV at 4, 7, and 24hr after administrationin comparison with placebo. However, there was no significant difference in time to angina disappear ance at 4, 7, and 24 hr after administration between celiprolol and placebo.Celiprolol significantly reduced systolic blood pressure at rest in a standing position and peak exercise, and peak exercise at 4 and 7hr after administration respectively in comparison with placebo. At 24hr after administration, tendency of reduction of systolic blood pressure was observed at peak exercise.There was no significant difference in diastolic blood pressure at 4, 7, and 24hr after administration between celiprolol and placebo. Celiprolol significantly reduced heart rate and pressure rate product (PRP) at peak exercise at 4, 7, and 24hr after administration in comparison with placebo.No significant difference in ST deviation was observed at peak exercise at 4, 7, and 24hr after administration between celiprolol and placebo. A tendentious or significant prolongation of alleviated exercise-induced ST depression (ST SXT) was observed at 4hr or at 7and 24hr after administration.Celiprolol significantly reduced heart rate, PRP, and ST deviation during exercise over 24hr.These results indicate that celiprolol significantly increases exercise tolerance in patients with stable effort angina pectoris over 24hr after a single oral administration of 400mg. It is concluded that celiprolol is a clinically useful antianginal agent.
400KeV Ag+ ions were irradiated to the (100) surfaces of 9.5m% Y2O3 stabilized ZrO2 with the doses ranging from 5×1015 ions/cm2 to 5×1017 ions /cm2 at room temperature in order to investigate the correlations between the state of implanted Ag and the suppression of crack initiation.1) Ag precipitated as particles in orienting the (200) face of Ag. The sizes of the Ag particles were ranging from 2nm(5×1016ions/cm2)to 11nm (5×1017ions/cm2).2) Knoop hardness of the surface of ZrO2 increased by about 20-30% by Ag+ ion-irradiation at the doses less than 5×1016ions/cm2 and decreased at the doses larger than 1×1017ions/cm2.3) Vickers indentation crack at a loads of 0.25N was completely suppressed in the surface of ZrO2 irradiated to a dose of 5×1017ions/cm2.4) The suppression of the crack initiation may be ascribed to the influence of the nanometer composite layer containing max. 23at% Ag.
Near-maximal treadmill exercise testing was performed on 26 normal individuals (NL) and 78 patients with coronary artery disease (CAD) using a modified Bruce's protocol. Exercise-induced changes in orthogonal P wave measurements were made automatically, using an averaging technique, immediately before and 30sec after treadmill exercise to assess their diagnostic significance in evaluation of left ventricular (LV) function in CAD patients. The maximal inferior and posterior components of the P wave and the maximal P-vector magnitude in the frontal and left sagittal planes showed a statistically significant increase after treadmill exercise both in NL and CAD patients. These changes were considered to be physiological responses of the P wave to dynamic exercise. The percent changes of the maximal horizontal P-vector magnitude (%Hmax) were significantly higher after treadmill exercise in CAD patients than in NL. In patients with effort angina pectoris and without a previous myocardial infarction, the %Hmax showed a highly significant negative correlation with the percent changes of the LV ejection fraction (r=0.66, p<0.01), measured by exercise RI angiography. These results suggest that the exercise-induced increase in %Hmax reflects transient impairment of LV function during exercise. It was concluded that a %Hmax of more than 120% provided a useful, noninvasive index for assessing LV function in treadmill exercise testing.
