Effat Sadat Farboud

Tehran University of Medical Sciences

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Saman Ahmad Nasrollahi

Tehran University of Medical Sciences

Rassoul Dinarvand

Tehran University of Medical Sciences

Changiz Taghibiglou

University of Saskatchewan

Ebrahim Azizi

Texas Tech University

Shadi Farsaei

Isfahan University of Medical Sciences

Sanaz Mahmoodi

Tehran University of Medical Sciences

Hossein Khalili

Tehran University of Medical Sciences

Mohammad Erfan

Institut Teknologi Nasional Malang

Reza Aboofazeli

Shahid Beheshti University of Medical Sciences

Mansour Nassiri Kashani

Tehran University of Medical Sciences

Cooperative Institutions

Tehran University of Medical Sciences

University of Tehran

Shahid Beheshti University of Medical Sciences

Iran University of Medical Sciences

Imam Khomeini Hospital

Ministry of Health and Medical Education

Ahvaz Jundishapur University of Medical Sciences

Children's Medical Center

Isfahan University of Medical Sciences

Shiraz University of Medical Sciences

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Sildenafil in the treatment of pressure ulcer: a randomised clinical trial

International Wound Journal (2013)

Shadi Farsaei Hossein Khalili Effat Sadat Farboud Zahra Khazaeipour

Pressure ulcer (PrU)-related hospitalisation and mortality are critical issues in medical and surgical patients. Although animal studies have suggested the beneficial effects of sildenafil on wound healing, related clinical data are lacking. This is the first clinical study that has evaluated the effects of topical sildenafil on PrU healing in human subjects. Enrolled patients were randomly allocated to receive topical sildenafil (10%) ointment or placebo daily. Wound healing was assessed visually and photographically by the change in wound score according to two-digit Stirling scale. Decreases in grades of the PrUs were significantly higher in sildenafil group compared with placebo group (P < 0·001). In addition, surface areas of ulcers in sildenafil group were significantly reduced compared to the control group at day 14 of intervention (P = 0·007). It appears that these effects may be mediated by improvement of microvascular reperfusion in the skin and soft tissue. Further study to emphasise the role of topical sildenafil in the prevention or treatment of PrUs in hospitalised patients is required.

10.1111/iwj.12104

Cite

Citations (23)

Preparation and characterization of biodegradable urea-loaded microparticles as an approach for transdermal delivery

Journal of Microencapsulation (2006)

Azita Haddadi Effat Sadat Farboud Mohammad Erfan Reza Aboofazeli

This work describes the formulation and characterization of urea-loaded microspheres prepared using various polymers such as ethyl cellulose (EC), cellulose acetate phthalate (CAP) and poly (D,L-lactic-co-glycolic acid) (PLGA), along with the utilization of a solvent evaporation technique. The effect of various formulation parameters (i.e. polymer type and concentration, vehicle type, polymer solution/vehicle volume ratio, drug/polymer ratio, homogenizer and stirrer speed, sonication time and speed, type of washing solution, drying and separation method) on the characteristics of microspheres was also evaluated. Results obtained indicated that, in the presence of urea, highest rate of EC microsphere production could be obtained at a drug/polymer ratio of 1:2 and a polymer solution/vehicle volume ratio of 1:50. In some cases, crystallization of urea was observed during the encapsulation process using cellulose derivative polymers. CAP microparticles showed a rough and tortuous surface while EC microparticles had a wider range of particle size. However, with the PLGA polymer, much better desired microparticles with a smaller size range of 1–3 µm were obtained. In general, PLGA microspheres were spherical in shape and possessed smooth surfaces with less pores in comparison with those obtained by the other polymers. The yield of particle production and the extent of urea encapsulation in PLGA particles were measured to be 68.87% ± 5.3 and 40.5% ± 3.4, respectively. The release study from PLGA microspheres revealed that up to 70% of the drug was released within a few days, through a four-stage release pattern.

Microparticle

10.1080/02652040600789328

Cite

Citations (7)

Avena sativa: An Effective Natural Ingredient in Herbal Shampoos for the Treatment of Hair Greasiness

Zenodo (CERN European Organization for Nuclear Research) (2013)

Effat Sadat Farboud Gholamreza Amin Leyla Akbari

Aims: Evaluation of anti-greasiness properties of oat extract and oil in shampoos. Methodology: Seborrhea can cause greasiness in scalp and hair. There are few compounds currently in use to reduce sebaceous gland secretions. Avena sativa or oat is a plant containing saponins as active ingredients with cleansing activity. In a double blinded, randomized, placebo clinical study, we investigated anti-grease and cleansing effects of oat by comparing shampoos formulated from oat extract and oil with control shampoo. Sixty male and female volunteers aged 19 to 30 years old randomly received either oat oil/extract or placebo to the scalp for 5 minutes, twice per week for four weeks. Signs and symptoms such as scaling, greasiness and itching were assessed every week. Results:In vitro detergency test revealed better detergency power in extract and Research Article

Ingredient

Avena

10.5281/zenodo.7903

Cite

Citations (2)

Potential role of statins on wound healing: review of the literature

International Wound Journal (2011)

Shadi Farsaei Hossein Khalili Effat Sadat Farboud

Wound healing is a dynamic and complex biological process, which requires coordinated events including haemostasis, inflammation, proliferation, revascularisation and remodelling. Impaired wound healing is a common problem that occurs in both community and hospital settings. Various experimental and clinical studies have evaluated different modalities for the treatment of topical wounds, such as sugar, antibiotics, honey and phytotherapies; also statins have diverse pleiotropic effects that have been suggested to be useful to improve wound healing. Data derived from both animal and human studies showed that statins especially atorvastatin, simvastatin and pravastatin can accelerate the wound-healing process. However, further high-quality and evidence-based studies are needed to address the best statin drug, appropriate dose, the best administration route, duration of treatment and to determine correlation between pleiotropic effects of statins and their probable clinical benefits.

10.1111/j.1742-481x.2011.00888.x

Cite

Citations (88)

4% hydroquinone versus 4% hydroquinone, 0.05% dexamethasone and 0.05% tretinoin in the treatment of melasma: a comparative study

International Journal of Dermatology (2004)

Reyhaneh Astaneh Effat Sadat Farboud Mohammad Javad Nazemi

A randomized, controlled, double‐blind clinical study was conducted on 64 patients (phototypes III to V) with melasma, in order to compare 4% hydroquinone cream with a combination product, containing 4% hydroquinone, 0.05% tretinoin and 0.05% dexamethasone, that can be applied as a single cream. The aim of this study was to determine whether hydroquinone provides additional improvement when combined with tretinoin and dexamethasone. Patients were randomly divided into two groups of 32 individuals. One group received 4% hydroquinone (group A) in a cream base. The other received a cream that contains 4% hydroquinone, 0.05% tretinoin and 0.05% dexamethasone (group B). The creams were applied once daily at night and a broad spectrum sunscreen (sun protection factor 15) was used every morning. Patients were evaluated by a clinical investigator subjectively at baseline and after 4, 8 and 12 weeks of therapy. At the baseline visit, the history of melasma, such as duration of disease, patient's age, type of melasma, distribution of melasma, family history, association with pregnancy, sun exposure, genetic factors and oral contraceptive consumption, was taken. Improvement was determined subjectively compared with baseline, on a three‐point scale as follows: worse, same and improved (excellent, good, moderate and slight). Descriptive statistics (the χ 2 test) were used to report the characteristics of the patients in the two groups.

Melasma

Hydroquinone

Tretinoin

Clinical study

10.1111/j.1365-4632.2004.02246.x

Cite

Citations (16)

Topical delivery of urea encapsulated in biodegradable PLGA microparticles: O/W and W/O creams

Journal of Microencapsulation (2008)

Azita Haddadi Reza Aboofazeli Mohammad Erfan Effat Sadat Farboud

This study describes the formulation and characterization of O/W and W/O creams containing urea-loaded microparticles prepared with poly (D, L-lactic-co-glycolic acid) (PLGA) in order to encapsulate and stabilize urea. The solvent evaporation method was used for preparing PLGA microparticles containing urea. The microparticles size was evaluated by laser light diffractometry. The resulting microparticles were then incorporated in O/W and W/O creams and stability and the release pattern from the creams was evaluated by UV-spectrophotometry. The particle size of PLGA microparticles was in the range of 1-5 microm and most microparticles had a particle size smaller than 3 microm. The encapsulation efficiency was calculated as 40.5% +/- 3.4. This study also examined release pattern of urea which varied among different formulations. The results showed that the release from O/W creams followed Higuchi kinetics while the release from W/O creams showed the zero order kinetics and the creams containing microparticulated urea had slower release than free urea creams.

Microparticle

PLGA

Disperse dye

10.1080/02652040802000714

Cite

Citations (17)

Cell‐penetrating Peptides as a Novel Transdermal Drug Delivery System

Chemical Biology & Drug Design (2012)

Saman Ahmad Nasrollahi Changiz Taghibiglou Ebrahim Azizi Effat Sadat Farboud

In the last decade, almost one-third of the newly discovered drugs approved by the US FDA were biomolecules and biologics. Effective delivery of therapeutic biomolecules to their target is a challenging issue. Innovations in drug delivery systems have improved the efficiency of many of new biopharmaceuticals. Designing of novel transdermal delivery systems has been one of the most important pharmaceutical innovations, which offers a number of advantages. The cell-penetrating peptides have been increasingly used to mediate delivery of bimolecular cargoes such as small molecules, small interfering RNA nucleotides, drug-loaded nanoparticles, proteins, and peptides, both in vitro and in vivo, without using any receptors and without causing any significant membrane damage. Among several different drug delivery routes, application of cell-penetrating peptides in the topical and transdermal delivery systems has recently garnered tremendous attention in both cosmeceutical and pharmaceutical research and industries. In this review, we discuss history of cell-penetrating peptides, cell-penetrating peptide/cargo complex formation, and their mechanisms of cell and skin transduction.

Cell-penetrating peptide

10.1111/cbdd.12008

Cite

Citations (126)

Efficacy of Topical Atorvastatin for the Treatment of Pressure Ulcers: A Randomized Clinical Trial

Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy (2013)

Shadi Farsaei Hossein Khalili Effat Sadat Farboud Iman Karimzadeh Mohammad Taghi Beigmohammadi

Study Objective To evaluate the effects of topical atorvastatin on the healing process of pressure ulcers in critically ill patients. Design Randomized, double-blind, placebo-controlled clinical trial. Setting Medical-surgical intensive care unit of a university-affiliated teaching hospital in Tehran, Iran. Patients One hundred four patients with stage I or II pressure ulcers, graded according to the 2-digit Stirling Pressure Sore Severity Scale. Intervention Patients were randomized to receive topical atorvastatin 1% ointment (51 patients [atorvastatin group]) or placebo ointment (53 patients [control group]) applied once/day to pressure ulcers for 14 days in addition to standard care for pressure ulcers. Measurements and Main Results The efficacy of each treatment was assessed on days 7 and 14. Efficacy was determined based on the degree of healing of the existing pressure ulcer by using the 2-digit Stirling scale. The baseline stage of the pressure ulcers did not differ significantly between the control and atorvastatin groups. However, the mean ± SD stage of pressure ulcers significantly decreased in the atorvastatin group compared with the control group on day 7 (0.97 ± 0.76 vs 1.74 ± 0.75, p<0.01) and day 14 (0.42 ± 0.67 vs 1.71 ± 0.78, p<0.01) of treatment. In addition, the mean ± SD surface areas of ulcers in the atorvastatin group were significantly declined compared with the control group after 7 days (5.55 ± 4.55 vs 9.41 ± 5.03 cm2, p<0.01) and 14 days (3.72 ± 4.45 vs 10.41 ± 6.41 cm2, p<0.01) of treatment. Conclusion Topical application of atorvastatin ointment 1% for 14 days in addition to standard care significantly accelerated the healing of stage I or II pressure ulcers in critically ill patients.

Pressure sores

10.1002/phar.1339

Cite

Citations (23)

Preparation of gelatin microspheres containing lactic acid--effect of cross-linking on drug release.

PubMed (2005)

Rassoul Dinarvand Sanaz Mahmoodi Effat Sadat Farboud Masoud ‎Salehi Fatemeh Atyabi

In this study, gelatin microspheres containing lactic acid were prepared by the polymerization technique using glutaraldehyde as the cross-linking agent. Dried microspheres were loaded by immersing them in an aqueous solution of lactic acid. In order to prepare microspheres with an appropriate drug release profile, the effect of time of cross-linking and the amount of cross-linking agent on the swelling properties of microspheres and their release profile were investigated. The microencapsulation efficiency, microspheres appearance, particle size, swelling ratio and drug release profile were also studied. Microspheres prepared with a larger amount of cross-linking agent, or after longer cross-linking time, showed a reduced swelling ratio in aqueous media. In vitro release pattern of lactic acid from gelatin microspheres showed a biphasic profile and the release rates were reduced upon increasing the amount of cross-liking agent and prolonging the cross-linking time.

Gelatin

Glutaraldehyde

Liberation

Source

Cite

Citations (56)

In vitro comparison of simple tretinoin-cream and cream loaded with tretinoin-SLN

journal of Pharmaceutical Technology and Drug Research (2013)

Saman Ahmad Nasrollahi Ali Abbasian Effat Sadat Farboud

Background: Tretinoin is one of the commonly used medications in treatment of skin aging symptoms.However, its topical application leads to local irritation at the application site which often limits its tolerability by patients.Solid lipid nanoparticles (SLN) have been developed as an alternative carrier system to emulsions with several advantages such as possibility of controlled drug release, drug targeting and increased drug stability.Methods: In this study, we formulated SLN with hot high pressure homogenization technique.For all formulations the lipid phase was dispersed in water containing 1-3% nonionic surfactant at 75 0 C and a premix was formed by homogenizing in an IKA Ultra Turrax high-speed stirrer followed by an IKA high pressure homogenizer.We applied 3, 5, 7 and 9 cycles at pressure range of 250-1000 bars.The z-average and zeta potential was analyzed by Malvern Zetasizer ZEN 3600. Results:The property of the particles depends on the amount of surfactant, production pressure and the number of homogenization cycles.The best formulation which was stable for two years contained 10% cetyl palmitate as a lipid, 2% tego care 450 as a surfactant and 88% water at 1000 bars (5 cycles) with z-average of 140±5 nm. Conclusion:The in vitro release studies showed that SLN containing tretinoin has prolonged profile as compared to commercially available tretinoin creams.It appears that the prolong release profile sustains permeation and absorption of tretinoin and also provides skin tolerability.

Tretinoin

Skin irritation

10.7243/2050-120x-2-13

Cite

Citations (11)