D. J. Alexander

Animal and Plant Health Agency

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R. J. Manvell

Veterinary Medicines Directorate

Ian H. Brown

Animal and Plant Health Agency

Ilaria Capua

Johns Hopkins University SAIS Bologna Center

J. Banks

Animal and Plant Health Agency

Michael Collins

Indiana University Health

G. Parsons

University of South Wales

E. Aldous

Monash Health

R. Gough

Veterinary Medicines Directorate

P. Reeve

Waikato District Health Board

Chad M. Fuller

Digital Research Alliance of Canada

Cooperative Institutions

Veterinary Medicines Directorate

Animal and Plant Health Agency

Central Veterinary Research Laboratory

Istituto Zooprofilattico Sperimentale delle Venezie

United States Department of Agriculture

The Pirbright Institute

St. Jude Children's Research Hospital

Royal Veterinary College

Cornell University

Ministry of Agriculture, Fisheries and Food

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Isolation of ortho‐ and paramyxoviruses from wild birds in Northern Ireland during the 1997 Newcastle disease epizootic

Veterinary Record (1999)

D. A. Graham Allison German Darrell Abernethy Sam McCullough R. J. Manvell

Northern Ireland

Newcastle Disease

Epizootic

10.1136/vr.145.1.20

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Citations (9)

Newcastle disease in pheasants (Phasianus colchicus): A review

The Veterinary Journal (2007)

E. Aldous D. J. Alexander

Phasianus

Newcastle Disease

Flock

10.1016/j.tvjl.2006.12.012

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Citations (55)

Animal and Human Health Implications of Avian Influenza Infections

Bioscience Reports (2007)

Ilaria Capua D. J. Alexander

Avian influenza (AI) is a listed disease of the World Organisation for Animal Health (OIE) that has become a disease of great importance both for animal and human health. Until recent times, AI was considered a disease of birds with zoonotic implications of limited significance. The emergence and spread of the Asian lineage highly pathogenic AI (HPAI) H5N1 virus has dramatically changed this perspective; not only has it been responsible of the death or culling of millions of birds, but this virus has also been able to infect a variety of non-avian hosts including human beings. The implications of such a panzootic reflect themselves in animal health issues, notably in the reduction of a protein source for developing countries and in the management of the pandemic potential. Retrospective studies have shown that avian progenitors play an important role in the generation of pandemic viruses for humans, and therefore these infections in the avian reservoir should be subjected to control measures aiming at eradication of the Asian H5N1 virus from all sectors rather than just eliminating or reducing the impact of the disease in poultry.

Culling

Pandemic

Highly pathogenic

Animal health

One Health

10.1007/s10540-007-9057-9

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Citations (48)

Evaluation of relationships between avian paramyxoviruses isolated from birds of the familyColumbidae

Archives of Virology (1991)

D. J. Alexander R. J. Manvell Michael Collins S. Brockman

Homology

10.1007/bf01319248

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Citations (12)

Newcastle disease in wild water birds in western Canada, 1990.

PubMed (1993)

Gary A. Wobeser Frederick A. Leighton Robert J Norman D J Myers D. K. Onderka

This report describes the investigation of mortality of double-crested cormorants (Phalacrocorax auritus), white pelicans (Pelecanus erythrorhynchos), and gulls (Larus spp.) in Alberta, Saskatchewan, and Manitoba during late summer 1990. Techniques used varied among areas, but virological and histopathological examination of birds was done in each area. The major clinical sign in cormorants was inability to fly, often with unilateral wing or leg paralysis. Focal nonsuppurative inflammation was present in the brain and spinal cord of cormorants and pelicans. Newcastle disease virus (NDV) was isolated from cormorants, a pelican, and a ring-billed gull (Larus delawarensls) from Saskatchewan. Cormorants from Alberta were positive for NDV in an immunofluorescent test. Most of the viruses were classed as velogenic and all had a similar monoclonal antibody profile to viruses from the 1970 to 1974 panzootic. Approximately half of cormorant, pelican, and gull eggs collected from affected colonies in the spring of 1991 had antibody to NDV. Antibody was also present in cormorant eggs from the Great Lakes. No unusual mortality was detected at any colony in 1991. Fledgling cormorants and gulls from colonies where mortality occurred in 1990 did not have antibody to NDV in June-July 1991. The overall extent of mortality among water birds and the source of the virus were not determined.

Cormorant

Pelican

Newcastle Disease

Source

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Citations (87)

Morphogenesis of avian infectious bronchitis virus in primary chick kidney cells

Archives of Virology (1976)

D. Chasey D. J. Alexander

Budding

10.1007/bf01317869

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Citations (44)

Modification of Newcastle Disease Virus Release and Cytopathogenicity in Cells treated with Plant Lectins

Journal of General Virology (1974)

George Poste D. J. Alexander P. Reeve Guy Hewlett

SUMMARY Binding of the plant lectins, concanavalin A (con A), wheat germ agglutinin, soybean agglutinin and Lens culinaris agglutinin to the surface of cells infected with different Newcastle disease virus (NDV) strains inhibited virus release. Binding of succinyl-con A with a lower valency than native tetrameric con A to the surface of infected cells did not inhibit virus release. It was proposed that binding of multivalent lectin molecules to the surface of infected cells impairs assembly of the virus envelope and the budding of new virus particles by the formation of cross-linkages and lattice formation between protein molecules on the cell surface. Binding of the same lectins to NDV-infected cells also caused significant inhibition of virus-induced cell fusion. In contrast, treatment of cells with a phytohaemagglutinin preparation from Phaseolus vulgaris enhanced NDV-induced cell fusion. A new form of NDV-induced c.p.e. was observed in lectin-treated cells involving extensive damage and fragmentation of cell nuclei. This c.p.e. was also found in lectin-treated cells infected with the avirulent NDV strains F and Queensland which normally induce only limited cell damage. The possible mechanisms underlying the varied effects of different lectins on NDV release and cytopathogenicity were discussed.

Soybean agglutinin

Newcastle Disease

Cell fusion

10.1099/0022-1317-23-3-255

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Citations (27)

Newcastle Disease Diagnosis

Developments in veterinary virology (1988)

D. J. Alexander

Newcastle Disease

10.1007/978-1-4613-1759-3_9

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