Kazuhiro Kondo

Jikei University School of Medicine

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Kazuo Chijiiwa

University of Miyazaki

Jiro Ohuchida

Miyazaki Prefectural Hospital

Masahiro Kai

Sapporo Medical University

Kazuhiro Otani

Jikei University School of Medicine

Masahide Hiyoshi

University of Miyazaki

Motoaki Nagano

University of Miyazaki

Hiroaki Kataoka

University of Miyazaki

Koichi Yamanishi

Osaka University

Ichiro Makino

Nippon Steel Yawata Memorial Hospital

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Naoya İmamura

University of Miyazaki

Cooperative Institutions

University of Miyazaki

University of Miyazaki Hospital

Osaka University

Jikei University School of Medicine

Kyushu University

Miyazaki Welfare Medical College

The University of Tokyo

Nagoya University

Fukuoka University

Yokohama City University

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Efficacy of Donepezil for Fatigue and Psychological Symptoms in Post-COVID-19 Condition: Study Protocol for a Multicenter Randomized, Placebo-controlled, Double-blind Trial

Annals of Clinical Epidemiology (2024)

Keiichiro Kawabata Kensuke Nakamura Kazuhiro Kondo Naomi Oka Azusa Ishii

Approximately 30% of coronavirus disease 2019 COVID-19 patients develop fatigue and psychological symptoms. We previously demonstrated the efficacy of donepezil, an acetylcholinesterase inhibitor that is widely used to treat dementia, in basic research.

2019-20 coronavirus outbreak

10.37737/ace.24013

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Effects of Preoperative Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma on Survival and Recurrence Depending on the TNM Stage, CLIP and JIS Scores

The Japanese Journal of Gastroenterological Surgery (2004)

Kazuhiro Kondo Kazuo Chijiiwa Ichiro Makino Masahiro Kai Tada-Aki Eto

はじめに: 肝細胞癌において, 術前に動注療法 (transcatheter arterial chemoembolization, TACE) を行うことにより術後生存率が向上するか, あるいは術後再発を抑制できるかは不明である. 今回, 肝細胞癌手術症例を進行度 (原発性肝癌取扱い規約によるTNM stage, Cancer of the Liver Italian Program (CLIP) score, Japan Integrated Staging (JIS) score) 別に分け, 術前動注療法の意義を検討した. 方法: 当科の肝細胞癌手術症例204例 (術前動注群73例, 非動注群131例) についてretrospectiveに検討した. 症例をTNM stage, CLIP score, JIS score別に分け, 術後生存率と再発までの期間を, 術前動注群と非動注群で比較した. 結果: 術後生存率は各stage, scoreにおいて群間に有意差はなく, CLIP score 1の症例では術前動注群が非動注群より術後生存率が低かった. 術後再発例 (術前動注群42例, 非動注群63例) における再発までの期間は, stage IIIとJIS score 2の症例で術前動注群の方が非動注群より有意に長かった. 考察: 肝細胞癌に対する術前動注療法は, 一般に術後生存率の向上や術後再発の抑制に寄与するとはいえず, ルーチンに行うべきではないと思われる. しかし, 症例によっては再発期間延長の効果があるかもしれない.

Transcatheter arterial chemoembolization

Liver Cancer

10.5833/jjgs.37.1705

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Prospective randomized controlled study of gastric emptying assessed by 13C-acetate breath test after pylorus-preserving pancreaticoduodenectomy: comparison between antecolic and vertical retrocolic duodenojejunostomy

Journal of Hepato-Biliary-Pancreatic Surgery (2008)

Kazuo Chijiiwa Naoya İmamura Jiro Ohuchida Masahide Hiyoshi Motoaki Nagano

10.1007/s00534-008-0004-3

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Vertical retrocolic duodenojejunostomy decreases delayed gastric emptying after pylorus-preserving pancreatoduodenectomy.

PubMed (2007)

Kazuo Chijiiwa Jiro Ohuchida Masahide Hiyoshi Motoaki Nagano Masahiro Kai

With the aim of preventing delayed gastric emptying (DGE) after pylorus-preserving pancreatoduodenectomy (PPPD), the new reconstruction method namely vertical retrocolic duodenojejunostomy in which the stomach and duodenum are brought down through the left side of the transverse mesocolon in a straight line thereby allowing these organs apart from the excised and anastomosed field and food passage by gravity is presented.The preoperative and intraoperative factors, and short-term outcomes with special reference to DGE were compared between the two groups, PPPD (n = 12) and standard pancreatoduodenectomy (PD, n = 9). PD was similarly carried out except for hemigastrectomy for comparison. DGE was defined as a need for nasogastric tube decompression for 10 days or more.Preoperative and intraoperative factors were not significantly different between the two groups. DGE was absent in both groups because nasogastric tube was removed within 7 days in all patients with a mean of postoperative day 3 in both groups. The days until liquid diet in the PPPD group were similar, but those until regular diet were significantly faster compared with the PD group. Postoperative hospital stay was similar between the two groups.The current reconstruction method may minimize DGE after PPPD.

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Expression of Hepatocyte Growth Factor Activator Inhibitor Type 1 in Human Hepatocellular Carcinoma and Postoperative Outcomes

World Journal of Surgery (2010)

Mayumi Funagayama Kazuhiro Kondo Kazuo Chijiiwa Hiroaki Kataoka

Tumor progression

10.1007/s00268-010-0517-1

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Citations (8)

[Oncogene (K-ras, p53, p16, DPC4, hTERTmRNA)].

PubMed (2015)

Kazuhiro Kondo Masahiro Kai

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Medical students' attitudes to laparoscopic surgery.

Hepatogastroenterology (2008)

Masayuki Hotokezaka Kazuo Chijiiwa Kazuhiro Kondo Masahiro Kai Tada-Aki Eto

The purpose of the present study was to evaluate the attitude of medical students to laparosocopic surgery.Two hundred and seven medical students completed a questionnaire regarding their visualization of, understanding of, and interest in observation of laparoscopic surgery via laparoscopic monitor (laparoscopic observation) and of open surgery, either directly (open direct observation), or via video monitor observation (open monitor observation). They were also asked about their willingness to become an operator (operator). Responses to each item were given as Likert-type scores ranging from 1 to 5.The visualization score was significantly lower for open direct observation than for open monitor observation (P<0.001) and laparoscopic observation (P<0.001), with the significantly lower score for open monitor observation than for laparoscopic observation (P<0.001). The understanding score was significantly lower for open direct observation than for open monitor observation (P<0.01) and laparoscopic observation (P<0.01). Interest scores did not differ between the three observation methods. The operator score was significantly higher for open surgery than for laparoscopic surgery.Laparoscopic surgery provides good visualization of the operative field. However, students' interest in laparoscopic surgery is similar to those of open surgery.

Open surgery

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HHV-6 Reactivation and Fatigue

Japanese Journal of Complementary and Alternative Medicine (2006)

Kazuhiro Kondo

疲労は，痛みや発熱と並んで非常に重要な生体シグナルであるが，疲労の原因や疲労を感じる機序は，全くと言っていいほど不明である．また，疲労・ストレスによるヘルペスウイルスの再活性化は，良く知られた現象であるが，学問的なアプローチはほとんどなされて来なかった．今回我々は，ヒトヘルペスウイルス 6 (HHV-6) の唾液中への再活性化が仕事による疲労によって誘導され，疲労のバイオマーカーとなり得ることを見出した．これは，HHV-6 の再活性化誘導因子の解明に役立つだけでなく，疲労の客観的な定量や疲労の機序の研究にも役立つものと考えられた．

10.1625/jcam.3.61

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Citations (3)

Impact of Anatomical Resection for Hepatocellular Carcinoma With Microportal Invasion (vp1)

Annals of Surgery (2018)

Masaaki Hidaka Susumu Eguchi Koji Okuda Toru Beppu Ken Shirabe

The aim of the present study was to evaluate the value of anatomical resection for hepatocellular carcinoma (HCC) with microportal vascular invasion (vp1) between 2000 and 2010.Vascular invasion has been reported as a prognostic factor of liver resection for HCC. Anatomical resection for HCC has resulted in optimum outcomes of eradicating intrahepatic micrometastases through the portal vein, but opposite results have also been reported.A clinical chart review was performed for 546 patients with HCC with vp1. We retrospectively evaluated the recurrence-free survival (RFS) between anatomical (AR) and nonanatomical resection (NAR). The site of recurrence was also compared between these groups. The influence of AR on the overall survival (OS) and RFS rates was analyzed in patients selected by propensity score matching, and the prognostic factors were identified.A total of 546 patients were enrolled, including 422 in the AR group and 124 in the NAR group. There was no difference in the 5-year OS and RFS rates between the 2 groups. Local recurrence was significantly more frequent in the NAR group than in the AR group. In a multivariate analysis, hepatitis C virus, serum protein induced by vitamin K absence II of 380 mAU/mL or more, tumor diameter of 5 cm or more, and age of 70 years or older were significant predictors of a poor RFS after liver resection. There were no significant differences in the OS or RFS between the AR and NAR groups by a propensity score-matched analysis.Although local recurrence around the resection site was suppressed by AR, AR for HCC with vp1 did not influence the RFS or OS rates after hepatectomy in the modern era.

Vascular invasion

10.1097/sla.0000000000002981

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Citations (75)

Corrigendum to “Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer’s disease” [Biochem. Biophys. Res. Commun. 430 (2013) 907–911]

Biochemical and Biophysical Research Communications (2014)

Nobuyuki Kobayashi Tomoyuki Nagata Shunichiro Shinagawa Naomi Oka Kazuya Shimada

Avidity

10.1016/j.bbrc.2014.06.071

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