Danny Alexander

Metabolon (United States)

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Jerome Schlomer

Frederick National Laboratory for Cancer Research

Rajaâ El Meskini

Frederick National Laboratory for Cancer Research

Zoë Weaver Ohler

Frederick National Laboratory for Cancer Research

Philip Martin

University of California Division of Agriculture and Natural Resources

Fátima Al‐Shahrour

Spanish National Cancer Research Centre

Terry Van Dyke

University of North Carolina at Chapel Hill

Alan Kulaga

Frederick National Laboratory for Cancer Research

Maureen Baran

Frederick National Laboratory for Cancer Research

Julián Carretero

Universitat de València

Theresa M. Guerin

Frederick National Laboratory for Cancer Research

Cooperative Institutions

University of Illinois Urbana-Champaign

Metabolon (United States)

University of North Carolina at Chapel Hill

United States Department of Agriculture

Johns Hopkins University

National Cancer Institute

University of California, Davis

Shanghai Jiao Tong University

Agricultural Research Service

The University of Texas Health Science Center at Houston

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Increasing resilience to cascading events: The M.OR.D.OR. scenario

Safety Science (2018)

Gianluca Pescaroli R. T. Wicks Giampiero Giacomello Danny Alexander

Vulnerability

Resilience

Preparedness

Component (thermodynamics)

10.1016/j.ssci.2017.12.012

Cite

Citations (39)

Supplementary Figure 5 from Temporal Molecular and Biological Assessment of an Erlotinib-Resistant Lung Adenocarcinoma Model Reveals Markers of Tumor Progression and Treatment Response

Zoë Weaver Ohler Simone Difilippantonio Julián Carretero Philip Martin Rajaâ El Meskini

<p>PDF file - 92K, LC-MS/MS validation for selected metabolites</p>

10.1158/0008-5472.22392290.v1

Cite

Citations (0)

Search for a Conversion‐Type Mutator System at the Rf₁ Locus in Maize¹

Crop Science (1962)

Danny Alexander J. B. Beckett

Geneticist

10.2135/cropsci1962.0011183x000200020016x

Cite

Citations (3)

Genetic Variation and Selection Response for Oil Composition in Corn¹

Crop Science (1986)

K. Pamin W. A. Compton C. E. Walker Danny Alexander

Our objectives were to study genetic variation and realized response to selection for oil quantity and quality. Information on genetic variation in broad based corn ( Zeam mays L.) population is needed for decisions about breeding methods to be used for oil enhancement in such populations. Quality measures are important for determining correlated responses to selection for high oil. Previous estimates have generally been based on generation means of narrow based populations. Genetic parameters of oil quantity and composition were estimated by analysis of 89 interpopulation full‐sib families and their S 1 line parents from ‘Nebraska B’ and ‘Nebraska Krugp’ populations. Percent oil was determined using Nuclear Magnetic Resonance spectroscopy. Fatty acid proportions were determined using gas‐liquid chromatographic analysis. Results revealed that significant genetic variation exists for both fatty acid composition and percent oil. Negative genetic correlation( r = −0.96) was found between oleic and linoleic acids, as expected. Percent oil was positively correlated with oleic ( r = 0.51) but negatively correlated with linoleic ( r = −0.48), suggesting a potential correlated response from selection of lowered quality with increased quantity of oil. A cycle of selection was completed and response to selection measured for three separate selection criteria (linoleic acid, total unsaturated fatty acids, and percent oil). Response to selection indicated that significant increases were obtained for each criterion. Both S 1 line per se and reciprocal full‐sib selection were effective, however linoleic acid was increased significantly more by the S 1 per se method. Our data indicate that oil quantity and quality can be changed by recurrent selection. It also appears that by careful monitoring of fatty acid proportions, oil quantity can be increased without lowering oil quality, at least for a few cycles.

Genetic correlation

10.2135/cropsci1986.0011183x002600020013x

Cite

Citations (18)

Erratum

Lipids (1971)

Evelyn J. Weber Andrée Roche Danny Alexander

10.1007/bf02531535

Cite

Citations (0)

Genetic Variability of Alpha‐Tocopherol and Gamma‐Tocopherol in Corn Embyros¹

Crop Science (1985)

H. L. Galliher Danny Alexander Evelyn J. Weber

Vitamin E is an essential component of animal diets. Two predominant isomers were known to exist in different ratios, as well as concentration, in corn ( Zea mays L.) grain. Furthermore, the biological value of the alpha isomer is substantially greater than gamma. The primary objective of this effort was to establish the magnitude of variation of the isomers and to estimate the rate of progress that might be expected through selection for the isomers individually or for total concentration. Alpha‐ and gamma‐tocopherol are the predominant vitamin E isomers in the embryos of corn. Tocopherol concentrations were determined in embryos of selfed seed of 100 S 1 families derived from RSSSC, a corn synthetic, grown in two replications of a replicates within block design in 1980 and 1981. Tocopherols were extracted, separated by high‐performance liquid chromatography on a silica absorption column, and quantified by ultraviolet absorbence detection. Concentrations of alpha‐tocopherol ranged from 0.0 to 138.2 μg/g embryo while concentrations of gammatocopherol ranged from 0.0 to 409.3 μ/g embryo. Average concentrations were 61.4 and 194.4 μ/g embryo for alpha‐ and gamma‐tocopherol, respectively. Family heritability estimates of 0.62 ± 0.16 and 0.68 ± 0.15 for alpha‐ and gamma‐tocopherol indicate that selection would be effective for either of these isomers.

alpha-Tocopherol

10.2135/cropsci1985.0011183x002500030028x

Cite

Citations (23)

Maize-targeted mutagenesis: A knockout resource for maize

Proceedings of the National Academy of Sciences (2003)

Bruce May Hong Liu Erik Vollbrecht Lynn Senior Pablo D. Rabinowicz

We describe an efficient system for site-selected transposon mutagenesis in maize. A total of 43,776 F 1 plants were generated by using Robertson's Mutator ( Mu ) pollen parents and self-pollinated to establish a library of transposon-mutagenized seed. The frequency of new seed mutants was between 10 –4 and 10 –5 per F 1 plant. As a service to the maize community, maize-targeted mutagenesis selects insertions in genes of interest from this library by using the PCR. Pedigree, knockout, sequence, phenotype, and other information is stored in a powerful interactive database (maize-targeted mutagenesis database) that enables analysis of the entire population and the handling of knockout requests. By inhibiting Mu activity in most F 1 plants, we sought to reduce somatic insertions that may cause false positives selected from pooled tissue. By monitoring the remaining Mu activity in the F 2 , however, we demonstrate that seed phenotypes depend on it, and false positives occur in lines that appear to lack it. We conclude that more than half of all mutations arising in this population are suppressed on losing Mu activity. These results have implications for epigenetic models of inbreeding and for functional genomics.

Transposon mutagenesis

Functional Genomics

10.1073/pnas.1831119100

Cite

Citations (121)

Experimental Corn Hybrids: 1952 Tests

L. F. Bauman Danny Alexander R. W. Jugenheimer C. M. Woodworth

Source

Cite

Citations (0)

Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy

European Journal of Clinical Investigation (2010)

Danny Alexander Raffaella Lombardi Gabriela Rodrı́guez Matthew M. Mitchell Ali J. Marian

Eur J Clin Invest 2011; 41 (5): 527–538 Abstract Background Metabolomics, the comprehensive profile of small-molecule metabolites found in biological specimens, has the potential to provide insights into the pathogenesis of disease states and lead to the identification of new biomarkers. Methods and Results We analysed 451 plasma metabolites by liquid chromatography/mass spectroscopy and gas chromatography/mass spectroscopy in 39 patients with primary dilated cardiomyopathy (DCM) and 31 age-, sex- and body mass index-matched controls. Sixty-one metabolites were significantly different between primary DCM and control individuals [false discovery rate (FDR) < 0·05]. Plasma levels of steroid metabolites, glutamine, threonine and histidine were reduced while levels of citric acid cycle intermediates and lipid β-oxidation products were increased in patients with primary DCM when compared to controls. Medications, particularly furosemide and angiotensin-1 converting enzyme-1 inhibitors, had significant effects on the plasma metabolites. Reduced levels of glutamine in conjunction with increased 3-methyhistidine and prolylhydroxyproline levels suggested enhanced myofibrillar and collagen degradation in DCM patients. Likewise, increased stachydrine and reduced indole-3-propionate implicated a role for intestinal-derived antioxidant molecules. Changes in steroid metabolites were notable for the loss of metabolic distinction between men and women in patients with primary DCM. Cortisol and cortisone levels were increased while androgen metabolites were decreased significantly, implying metabolic 'feminization' of men with primary DCM. Conclusions Metabolomic profiling identifies biologically active metabolites that could serve as markers of primary DCM and impart protective or harmful effects on cardiac structure and function.

Dilated Cardiomyopathy

Pathogenesis

10.1111/j.1365-2362.2010.02441.x

Cite

Citations (91)

Supplementary Table 3 from Temporal Molecular and Biological Assessment of an Erlotinib-Resistant Lung Adenocarcinoma Model Reveals Markers of Tumor Progression and Treatment Response

Zoë Weaver Ohler Simone Difilippantonio Julián Carretero Philip Martin Rajaâ El Meskini

<p>XLS file - 395K, Identities of all metabolites detected, grouped by class of compound</p>

Table (database)

10.1158/0008-5472.22392272

Cite

Citations (0)