Xingming Jiang

Harbin Medical University

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Yunfu Cui

Harbin Medical University

Zhenglong Li

Harbin Medical University

Xiangyu Zhong

Harbin Medical University

Jinglin Li

Harbin Medical University

Yi Xu

Guangxi University

Pengcheng Kang

Loudi Central Hospital

Kaiming Leng

Qingdao University

Lining Huang

Suzhou Municipal Hospital

Canghai Guan

Harbin Medical University

Zhidong Wang

Harbin Medical University

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Harbin Medical University

103

Second Affiliated Hospital of Harbin Medical University

Sun Yat-sen University

Chinese Academy of Sciences

Second Military Medical University

Eastern Hepatobiliary Surgery Hospital

Zhejiang University

Nanjing Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Hebei Medical University

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Overexpression of long noncoding RNA H19 indicates a poor prognosis for cholangiocarcinoma and promotes cell migration and invasion by affecting epithelial-mesenchymal transition

Biomedicine & Pharmacotherapy (2017)

Yi Xu Zhidong Wang Xingming Jiang Yunfu Cui

10.1016/j.biopha.2017.05.061

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Citations (50)

ZNF460-mediated upregulation of APCDD1L-DT promotes cholangiocarcinoma development by inhibiting the ubiquitin-mediated degradation of DVL2

Cancer Gene Therapy (2024)

Xin Gao Xinlei Zou Canghai Guan Xiangjun Sha Sidi Liu

10.1038/s41417-024-00826-z

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Citations (1)

Progress of long non-coding RNA LINC00152 in gastrointestinal cancer

Zhongliu yanjiu yu linchuang (2017)

Wangyang Zheng Zhenglong Li Jinglin Li Xinheng Li Zhidong Wang

With the advance of biology technology, non-coding RNA (ncRNA) has been confirmed to be closely associated with the occurrence and development of the cancer. The ncRNA can be divided into two groups by length, including microRNA (miRNA) and long non-coding RNA (lncRNA). As a member of lncRNA, LINC00152 (long intergenic non-protein-coding RNA 152) has been taken into cancer research, which can regulate the activity of miRNA and involve the regulation of gene transcription of gene transcription and protein generation. The characteristics of LINC00152 that correlate with many clinical manifestations and can be detected in liquid biopsies make it becoming new biomarkers of cancer diagnosis. This paper reviews the current progress of LINC00152 in gastrointestinal cancer. Key words: Digestive system neoplasms; Long non-coding RNA; Long intergenic non-protein-coding RNA 152; Tumor markers, biological

Intergenic region

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Circular RNA

10.3760/cma.j.issn.1006-9801.2017.09.017

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The role of long non-coding RNA AFAP1-AS1 in human malignant tumors

Pathology - Research and Practice (2018)

Daolin Ji Xiangyu Zhong Xingming Jiang Kaiming Leng Yi Xu

Tumor progression

10.1016/j.prp.2018.08.014

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Citations (54)

The regulatory effect and mechanisms of LncRNA CRNDE in digestive system tumors

Zhongguo yishi zazhi (2019)

Jiaxin Wang Yuanshi Zhou Xingming Jiang Weina Wang

Long non-coding RNA regulates gene expression at multiple levels (epigenetics, transcriptional level, post-transcriptional level) and plays an important role in the development and progression of individual development and tumors. With the deep research, it is found that LncRNA CRNDE is an important cancer-related long non-coding RNA, and it is necessary to understand the specific role of LncRNA CRNDE in regulating tumor cell life activities. In recent years, the role of LncRNA CRNDE in tumorigenesis and development has been increasing. It has been found that LncRNA CRNDE is up-regulated in various tumors and is closely related to tumor proliferation, invasion, metastasis and patients′ prognosis, becoming a new hot spot in cancer research. The author combines the latest literatures at home and abroad to review the role and mechanism of LncRNA CRNDE in the development of digestive system tumors, hoping to prevent and treat tumors in the future. Key words: Digestive system neoplasms; RNA, long noncoding; Gene expression regulation, neoplastic; Review

10.3760/cma.j.issn.1008-1372.2019.05.045

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Linc00473 potentiates cholangiocarcinoma progression by modulation of DDX5 expression via miR-506 regulation

Cancer Cell International (2020)

Lining Huang Xingming Jiang Zhenglong Li Jinglin Li Xuan Lin

Cholangiocarcinoma (CCA) is a mortal cancer with high mortality, whereas the function and mechanism of occurrence and progression of CCA are still mysterious. Long non-coding RNAs (lncRNAs) could function as important regulators in carcinogenesis and cancer progression. Growing evidences have indicated that the novel lncRNA linc00473 plays an important role in cancer progression and metastasis. However, its function and molecular mechanism in CCA remain unknown.The linc00473 expression in CCA tissues and cell lines was analyzed using qRT-PCR. Gain- and loss-of-function experiments were conducted to investigate the biological functions of linc00473 both in vitro and in vivo. Insights into the underlying mechanisms of competitive endogenous RNAs (ceRNAs) were determined by bioinformatics analysis, dual-luciferase reporter assays, qRT-PCR arrays, RNA immunoprecipitation (RIP) and rescue experiments.Linc00473 was highly expressed in CCA tissues and cell lines. Linc00473 knockdown inhibited CCA growth and metastasis. Furthermore, linc00473 acted as miR-506 sponge and regulated its target gene DDX5 expression. Rescue assays verified that linc00473 modulated the tumorigenesis of CCA by regulating miR-506.The data indicated that linc00473 played an oncogenic role in CCA growth and metastasis, and could serve as a novel molecular target for treating CCA.

Competing Endogenous RNA

10.1186/s12935-020-01415-4

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Citations (11)

ZEB1‐AS1: A crucial cancer‐related long non‐coding RNA

Cell Proliferation (2017)

Jinglin Li Zhenglong Li Kaiming Leng Yi Xu Daolin Ji

Abstract Long non‐coding RNA s (lnc RNA s) recently emerge as a novel class of non‐coding RNA s (nc RNA s) with larger than 200 nucleotides in length. Due to lack an obvious open reading frame, lnc RNA s have no or limited protein‐coding potential. To date, accumulating evidence indicates the vital regulatory function of lnc RNA s in pathological processes of human diseases, especially in carcinogenesis and development. Deregulation of lnc RNA s not only alters cellular biological behavior, such as proliferation, migration and invasion, but also represents the poor clinical outcomes. Zinc finger E‐box binding homeobox 1 antisense 1 ( ZEB 1‐ AS 1), an outstanding cancer‐related lnc RNA , is identified as an oncogenic regulator in diverse malignancies. Dysregulation of ZEB 1‐ AS 1 has been demonstrated to exhibit a pivotal role in tumorigenesis and progression, suggesting its potential clinical value as a promising biomarker or therapeutic target for cancers. In this review, we make a summary on the current findings regarding the biological functions, underlying mechanisms and clinical significance of ZEB 1‐ AS 1 in cancer progression.

Competing Endogenous RNA

Small nucleolar RNA

RNA Silencing

10.1111/cpr.12423

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Citations (62)

Regulatory effect of LncRNA HOTTIP in digestive system neoplasms

International Journal of Surgery (2017)

Xingming Jiang Zhidong Wang Wangyang Zheng Jinglin Li Zhenglong Li

10.3760/cma.j.issn.1673-4203.2017.08.019

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Research of tumor progression locus 2 in tumorigenesis and progression

中国医师杂志 (2017)

Jinglin Li Wangyang Zheng Xinheng Li Zhenglong Li Zhidong Wang

Tumor progression locus 2 (Tpl2) is a crucial three-stage kinase of the mitogen-activited protein kinase (MAPK) family, which plays an important role in MAPK pathway and other signaling pathways. In recent years, a large number of studies have found that aberrant expressing Tpl2 is involved in tumorigenesis and development of various cancers, and is expected to serve as a new biomarker and therapeutic target. Therefore, to reveal the mechanism of Tpl2 will provide a feasible theoretical basis and potential interventional target for the diagnosis and treatment of cancers. Key words: Mitogen-activated protein kinase kinases; Neoplasms; Review

Tumor progression

10.3760/cma.j.issn.1008-1372.2017.06.049

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Regulatory effect of lncRNA DANCR in malignant neoplasms

Int J Immunol (2018)

Xingming Jiang Sheng Tai Xiangyu Zhong Zhidong Wang

The long non-coding RNA (lncRNA) is one of the key members of ncRNA family.Many studies have demonstrated that dysregulated lncRNAs are involved in multiple pathophysiological processes and play important regulatory roles.It is found that the lncRNA DANCR (differentiation antagonizing non-coding RNA) could regulate the process of articular cartilage repair, osteogenic differentiation and endodontic cell differentiation.LncRNA DANCR, Which was upregulated in various human carcinomas, could promote the malignant behaviors of tumor cells including proliferation, invasion, metastasis, anti-apoptosis and EMT through different mechanisms.LncRNA DANCR could be the biomarker for the diagnosis/therapy and prognosis evaluation of cancer patients.Here we summarize the regulatory effect of lncRNA DANCR in malignant neoplasms. Key words: LncRNA; DANCR; Malignant neoplasms; Regulatory effect

MALAT1

10.3760/cma.j.issn.1673-4394.2018.03.014

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