Marco Rolando

Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele

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Giacomo Ingallina

Vita-Salute San Raffaele University

Francesco Melillo

Vita-Salute San Raffaele University

Stefano Stella

Vita-Salute San Raffaele University

Alfredo Brusco

University of Turin

Eleonora Di Gregorio

Azienda Ospedaliera Citta' della Salute e della Scienza di Torino

Eustachio Agricola

Vita-Salute San Raffaele University

Francesco Ancona

Mylan (Switzerland)

P. Solero

University of Turin

Antonio Boccellino

IRCCS Policlinico San Donato

Francesco Piroli

Azienda Sanitaria Unità Locale di Reggio Emilia

Cooperative Institutions

Istituti di Ricovero e Cura a Carattere Scientifico

Policlinico San Matteo Fondazione

University of Pavia

University of Turin

Vita-Salute San Raffaele University

Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele

San Raffaele University of Rome

IRCCS Ospedale San Raffaele

Azienda Ospedaliera Citta' della Salute e della Scienza di Torino

University of Milan

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Heterozygous Deletion of KLHL1/ATX8OS at the SCA8 Locus Is Unlikely Associated With Cerebellar Impairment in Humans

The Cerebellum (2015)

Giorgia Mandrile Eleonora Di Gregorio Himanshu Goel Daniela Giachino Stefania De Mercanti

10.1007/s12311-015-0679-3

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Citations (3)

“A de novo X;8 translocation in a patient with psychomotor retardationand congenital cerebellar hypoplasia creates a PTK2-THOC2 fusion gene and knocks down THOC2 expression by transcriptional interference”

Eleonora Di Gregorio F. Bianchi Alfonso Schiavi Alessandra M.A. Chiotto Marco Rolando

Psychomotor retardation

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Early Complete Revascularization in Hemodynamically Stable Patients With ST-Segment Elevation Myocardial Infarction and Multivessel Disease

Canadian Journal of Cardiology (2019)

Federico Fortuni Gabriele Crimi Filippo Angelini Sergio Leonardi Fabrizio D’Ascenzo

Elevation (ballistics)

10.1016/j.cjca.2019.03.006

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Citations (9)

Giant right pulmonary vein thrombus

Authorea (Authorea) (2020)

Marco Rolando Giacomo Ingallina Renata Mellone Stefano Stella Francesco Ancona

Pulmonary Vein Thrombosis (PVT) is a rare and insidious condition with only few case series and case reports described in literature. PVT effects on pulmonary circulation is similar to mitral stenosis and its haemodynamic consequences depend on the number of veins involved, the obstruction severity and the pulmonary vessels compliance. Here we present a case in which a multimodality approach with Transesophageal Echocardiography (TEE) and Computed Tomography (CT) imaging helped to guide therapeutic decisions. Specifically, a post-processing reconstruction of TEE projection directly from CT imaging was performed.

Pulmonary vein stenosis

10.22541/au.159809495.50629475

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Are Delayed Evoked Oto-Acoustic Emissions (DEOE) Solely the Outcome of an Active Intracochlear Mechanism?

Scandinavian Audiology (1989)

Giovanni Rossi P. Solero Marco Rolando Massimo Olina

Post-mumps and post-measles hearing losses are a result of the destruction of Corti's organ. Both the basilar and the Reissner membranes are unimpaired. In 11 subjects with post-mumps (8 cases) and post-measles (3 cases) unilateral anacusis, DEOE with a mean amplitude lower than that of the contralateral normal ear with the same sensation level were observed with 0.5, 1 and 2 kHz tone-bursts and air conduction stimulation. These findings lend credit to the view that DEOE could in part be produced by a passive intracochlear mechanism, probably a consequence of the basilar membrane travelling wave induced by the displacement of the perilymph. In a normal ear, this passive mechanism could be superimposed by an active machanism linked to the contractile activity of the outer hair cells (OHC) which modulates and increases the travelling wave depth.

Basilar membrane

Perilymph

10.3109/01050398909070729

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Citations (6)

Mortality is higher in patients with leptomeningeal metastasis in spinal cord tumors é mais elevada na disseminação metastática leptomeníngea em tumores da

Ricardo de Amoreira Gepp José Mauro Cardoso Couto Maria Dorvalina da Silva Marco Rolando Sainz Quiroga

Spinal cord tumors are a rare neoplasm of the central nervous system (CNS). The occurrence of metastases is related to poor prognosis. The authors analyzed one series of metastasis cases and their associated mortality. Methods: Clinical characteristics were studied in six patients with intramedullary tumors with metastases in a series of 71 surgical cases. Results: Five patients had ependymomas of which two were WHO grade III. The patient with astrocytoma had a grade II histopathological classification. Two patients required shunts for hydroceph alus. The survival curve showed a higher mortality than the general group of patients with no metastases in the CNS (p<0.0001). Conclusion: Mortality is elevated in patients with metastasis and greater than in patients with only primary lesions. The ependymomas, regardless of their degree of anaplasia, are more likely to cause metastasis than spinal cord astrocytomas.

Anaplasia

Spinal Cord Neoplasm

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Barriers associated with emergency medical service activation in patients with ST-segment elevation acute coronary syndromes

Internal and Emergency Medicine (2021)

Enrico Baldi Rita Camporotondo Massimiliano Gnecchi Rossana Totaro Stefania Guida

10.1007/s11739-021-02894-7

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Citations (4)

Subclinical myocardial dysfunction in patients recovered from COVID‐19

Echocardiography (2021)

Leonardo Italia Giacomo Ingallina Antonio Napolano Antonio Boccellino Martina Belli

Myocardial injury (MI) can be detected during the acute phase of Coronavirus disease 19 (COVID-19) and is associated with a dismal prognosis. Recent imaging studies described the persistence of cardiac abnormalities after the recovery. The aim of the study was to investigate the spectrum of cardiac abnormalities at mid-term follow-up in patients recovered from COVID-19 using clinical assessment, laboratory tests, and imaging evaluation with comprehensive echocardiography.This is an observational, cross-sectional study assessing an unselected cohort of consecutive patients recovered from COVID-19. MI was defined by elevated plasma levels of high sensitive troponin T (hsTnT). At the follow-up, a complete examination including echocardiography was performed.The 123 patients included were divided into two groups according to the presence of MI during hospitalization: group A (without MI) and group B (with MI). After a median of 85 days, group B patients were more frequently symptomatic for dyspnea and had significantly higher values of hsTnT and N-Terminal prohormone of Brain Natriuretic Peptide (NT-proBNP), compared to Group A. No differences between the two groups in left nor right ventricle dimension and ejection fraction were found. However, in group B a significant reduction of mean left ventricle global longitudinal strain was observed (-15.7±.7 vs -18.1± .3 in group A, p < 0.001), together with higher frequency of impaired diastolic function and higher values of pulmonary pressure.In patients recovered from COVID-19, echocardiography with speckle-tracking analysis may be an useful imaging tool to identify subclinical myocardial dysfunction and potentially guide management strategies.

Subclinical infection

Speckle tracking echocardiography

10.1111/echo.15215

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Citations (22)

Transcatheter Mitral Valve Intervention: Current and Future Role of Multimodality Imaging for Device Selection and Periprocedural Guidance

Leonardo Brugiatelli Marco Rolando Carla Lofiego Marco Fogante Irene Capodaglio

Mitral regurgitation (MR) is a broadly diffuse valvular heart disease (VHD) with a significant impact on healthcare system and patient’s prognosis. Transcatheter mitral valve interventions (TMVI) are now well-established techniques included in the therapeutic armamentarium for managing patients with mitral regurgitation, either primary or functional MR. Even if guidelines give indications regarding the correct management of this VHD, the wide heterogeneity of patient’s clinical background, valvular and heart’s anatomy make each patient a unique case, in which the appropriate device’s selection requires a multimodality imaging evaluation and a multidisciplinary discussion. Proper pre-procedural evaluation plays a pivotal role to judge the feasibility of TMVI, as well as a cooperative works between imagers and interventionalist is crucial for procedural success. This manuscript aims to provide an exhaustive overview of the main parameters that need to be evaluated for appropriate device selection, pre-procedural planning, intraprocedural guidance and post-operative assessment in the setting of TMVI. In addition, it tries to give some insights about next perspective of structural cardiovascular imaging.

valvular heart disease

Multimodality

10.20944/preprints202406.0726.v1

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Citations (1)

Persistent pulmonary vein thrombosis

The International Journal of Cardiovascular Imaging (2020)

Marco Rolando Giacomo Ingallina Stefano Stella Renata Mellone Francesco Ancona

10.1007/s10554-020-02096-w

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Citations (1)