Goo‐Young Kim

National Institutes of Health

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Hyangshuk Rhim

Catholic University of Korea

Janice Y. Chou

National Institutes of Health

Jun‐Ho Cho

University of Connecticut

Brian C. Mansfield

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Young‐Mock Lee

Yonsei University

Joon Hyun Kwon

Asan Medical Center

Min-Kyung Nam

Catholic University of Korea

Minhyuk Yun

LG Chem (South Korea)

Jin Han

Inje University

Kyung Soo Ko

Inje University

Cooperative Institutions

Catholic University of Korea

Korea University

Chungnam National University

Seoul National University

Sungkyunkwan University

Yonsei University

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institutes of Health

Seoul St. Mary's Hospital

Samsung (South Korea)

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A new idea for simple and rapid monitoring of gene expression: requirement of nucleotide sequences encoding an N-terminal HA tag in the T7 promoter-driven expression in E. coli

Biotechnology Letters (2012)

Jeong-Mi Moon Goo‐Young Kim Hyangshuk Rhim

Shuttle vector

10.1007/s10529-012-0966-8

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Citations (11)

Construction of UHV Scanning Tunneling Microscope

Journal of the Korean Society for Nondestructive Testing (1994)

Ja-Yong Koo Dal-Hyun Kim Hae-Won Park Goo‐Young Kim Se-Kyung Lee

A scanning tunneling microscope has been built, which can resolve atomic arrangements of conductors and semiconductors in ultra high vacuum below Torr. Its background and operational principles are reviewed and the guide lines in building the scanning tunneling microscope are shown. The results of measurements for highly oriented pyrolytic graphite and Si(111) surface are presented.

Torr

Scanning Probe Microscopy

Pyrolytic carbon

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Liver-directed gene therapy for murine glycogen storage disease type Ib

Human Molecular Genetics (2017)

Joon Hyun Kwon Young‐Mock Lee Jun‐Ho Cho Goo‐Young Kim Javier Anduaga

Glycogen storage disease type-Ib (GSD-Ib), deficient in the glucose-6-phosphate transporter (G6PT), is characterized by impaired glucose homeostasis, myeloid dysfunction, and long-term risk of hepatocellular adenoma (HCA). We examined the efficacy of G6PT gene therapy in G6pt−/− mice using recombinant adeno-associated virus (rAAV) vectors, directed by either the G6PC or the G6PT promoter/enhancer. Both vectors corrected hepatic G6PT deficiency in murine GSD-Ib but the G6PC promoter/enhancer was more efficacious. Over a 78-week study, using dose titration of the rAAV vectors, we showed that G6pt−/− mice expressing 3–62% of normal hepatic G6PT activity exhibited a normalized liver phenotype. Two of the 12 mice expressing < 6% of normal hepatic G6PT activity developed HCA. All treated mice were leaner and more sensitive to insulin than wild-type mice. Mice expressing 3–22% of normal hepatic G6PT activity exhibited higher insulin sensitivity than mice expressing 44–62%. The levels of insulin sensitivity correlated with the magnitudes of hepatic carbohydrate response element binding protein signaling activation. In summary, we established the threshold of hepatic G6PT activity required to prevent tumor formation and showed that mice expressing 3–62% of normal hepatic G6PT activity maintained glucose homeostasis and were protected against age-related obesity and insulin resistance.

Hepatocellular adenoma

Homeostasis

10.1093/hmg/ddx325

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Citations (17)

Gallic acid-mitochondria targeting sequence-H₃R₉ induces mitochondria-targeted cytoprotection

Korean Journal of Physiology and Pharmacology (2021)

Yoonhee Bae Goo‐Young Kim Jessa Flores Kyung Soo Ko Jin Han

The development of selective targeting of drug molecules towards the mitochondria is an important issue related to therapy efficacy. In this study, we report that gallic acid (GA)-mitochondria targeting sequence (MTS)-H3R9 exhibits a dual role as a mitochondria-targeting vehicle with antioxidant activity for disease therapy. In viability assays, GA-MTS-H3R9 showed a better rescue action compared to that of MTS-H3R9. GA-MTS-H3R9 dramatically exhibited cell penetration and intercellular uptake compared to MTS and fit escape from lysosome release to the cytosol. We demonstrated the useful targeting of GA-MTS-H3R9 towards mitochondria in AC16 cells. Also, we observed that the antioxidant properties of mitochondrial-accrued GA-MTSH3R9 alleviated cell damage by reactive oxygen species production and disrupted mitochondrial membrane potential. GA-MTS-H3R9 showed a very increased cytoprotective effect against anticancer activity compared to that of MTS-H3R9. We showed that GA-MTS-H3R9 can act as a vehicle for mitochondria-targeting and as a reagent for therapeutic applications intended for cardiovascular disease treatment.

Cytoprotection

Viability assay

10.4196/kjpp.2022.26.1.15

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Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia

Journal of Inherited Metabolic Disease (2018)

Jun‐Ho Cho Goo‐Young Kim Brian C. Mansfield Janice Y. Chou

Sirtuin 1

10.1007/s10545-018-0192-1

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Citations (28)

Glycogen storage disease type Ib neutrophils exhibit impaired cell adhesion and migration

Biochemical and Biophysical Research Communications (2016)

Goo‐Young Kim Young‐Mock Lee Joon Hyun Kwon Hyun Sik Jun Janice Y. Chou

Neutrophil Extracellular Traps

10.1016/j.bbrc.2016.11.075

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Metabolic Alterations of the Zebrafish Brain after Acute Alcohol Treatment by¹H Nuclear Magnetic Resonance Spectroscopy

Journal of Spectroscopy (2013)

Dong‐Cheol Woo Goo‐Young Kim Hyunju Kim Eunjung Bang Hyangshuk Rhim

The purpose of this study is to investigate the metabolic alterations associated with acute alcohol treatment in zebrafish by 1 H nuclear magnetic resonance spectroscopy (NMRS). The brain metabolism of zebrafish was investigated after acute alcohol treatment (one-hour long exposure of adult fish to 0.00%, 0.25%, 0.50%, or 1.00% ethyl alcohol) with whole brain extraction. The results of this study showed that glutamate (Glu) was significantly decreased, scyllo-inositol (sIns) showed a small apparent increase only in the highest acute treatment dose group, and myoinositol (mIns) showed a significant decrease. [Glu]/[tCr] and [mIns]/[tCr] levels were significantly reduced regardless of the alcohol dose, and [sIns]/[tCr] was increased in the highest alcohol treatment dose group. The present NMR study revealed that specific metabolites, such as Glu and mIns, were substantially decreased in case of acute alcohol exposed zebrafish brain.

10.1155/2013/971914

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Citations (3)

Molecular biology and gene therapy for glycogen storage disease type Ib

Journal of Inherited Metabolic Disease (2018)

Janice Y. Chou Jun‐Ho Cho Goo‐Young Kim Brian C. Mansfield

10.1007/s10545-018-0180-5

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Citations (26)

Dipeptide-functionalized polyamidoamine dendrimer-mediated apoptin gene delivery facilitates apoptosis of human primary glioma cells

International Journal of Pharmaceutics (2016)

Yoonhee Bae Eric S. Green Goo‐Young Kim Su Jeong Song Ji Young Mun