Birnur Akkaya

Sivas Cumhuriyet Üniversitesi

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Recep Akkaya

Sivas Cumhuriyet Üniversitesi

SÇ

Serap Çetinkaya

Sivas Cumhuriyet Üniversitesi

Ali Fazıl Yenidünya

Sivas Cumhuriyet Üniversitesi

Samet Kocabay

Inonu University

Jane A. Little

University of North Carolina at Chapel Hill

Sebahattin Karabulut

Sivas Cumhuriyet Üniversitesi

Umut A. Gürkan

Case Western Reserve University

Sevgi Yavuz

Istanbul Metropolitan Municipality

AŞ

Ahmet Şevki Taşkıran

Sivas Cumhuriyet Üniversitesi

Nurgül Sarıaydin

Sivas Cumhuriyet Üniversitesi

Cooperative Institutions

Sivas Cumhuriyet Üniversitesi

Case Western Reserve University

Sakarya University

Erciyes University

Cleveland BioLabs (United States)

Czech Academy of Sciences, Institute of Physiology

Adli Tıp Kurumu

University of North Carolina at Chapel Hill

University of North Carolina Health Care

Communities In Schools of Orange County

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Molecular docking to investigate the inhibitory activity and the role of nitric oxide in anticonvulsant effects of vitamin D on pentylenetetrazole‑induced epileptic seizures in rats

Journal of Molecular Structure (2022)

Recep Akkaya Birnur Akkaya Ridwan Opeyemi Bello

10.1016/j.molstruc.2022.134246

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Citations (2)

Adsorption isotherms, kinetics, thermodynamics and desorption studies for uranium and thorium ions from aqueous solution by novel microporous composite P(HEMA-EP)

Journal of Nuclear Materials (2012)

Recep Akkaya Birnur Akkaya

Endothermic process

Uranyl

10.1016/j.jnucmat.2012.11.056

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Citations (26)

Selective and single step adsorption of α-lactalbumin from whole cow's milk on hydroxyapatite microbeads

Materials Science and Engineering C (2016)

Serap Çetinkaya Birnur Akkaya

Alpha-lactalbumin

Cow milk

10.1016/j.msec.2016.06.040

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Citations (6)

New low-cost composite adsorbent synthesis and characterization

Desalination and Water Treatment (2013)

Recep Akkaya Birnur Akkaya

Abstract In this research, a novel composite, poly(acrylamide-expanded perlite) [P(AAm-EP)], was synthesized and characterized. The chemical synthesis was achieved by using free-radical polymerization and a number of structural characterization methods, including Fourier-transformed infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer–Emmett–Teller (BET)-porosity, and swelling tests. Free-radical polymerization of acrylamide (AAm) over expended perlite (EP) was successfully performed. The effect of reaction variables, such as dosage of the initiator, total concentration of the reactants, reactant ratio, mixing time, temperature, and reaction time, were investigated in detail. Expended perlite was cross-linked with acrylamide to enhance its chemical resistance. P(AAm-EP) composite has a specific surface area of 31.7 m2 g−1. Keywords: CompositePolyacrylamideChemical synthesisInfrared spectroscopyExpanded perlite Acknowledgment This work was supported by The Research Fund of Cumhuriyet University (CÜBAP, Project No: F-321) to which the author is grateful.

Perlite

10.1080/19443994.2012.749374

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Wi-Fi decreases melatonin protective effect and increases hippocampal neuronal damage in pentylenetetrazole induced model seizures in rats

Pathophysiology (2019)

Recep Akkaya Erkan Gümüş Birnur Akkaya Sebahattin Karabulut Kader Gülmez

Epilepsy is a common brain disorder in which the seizures could cause a neuronal loss in the hippocampus. Oxidative stress has an important role in the pathology of epilepsy. Some studies indicate that Wi-Fi increases oxidative stress and suppresses antioxidant systems. The aim of this study is to investigate the effect of Wi-Fi on melatonin anticonvulsive effect and oxidative damage in pentylenetetrazole-induced epileptic seizures in rats.In our study, we used 30 male Wistar Albino rats, 230-250 grams of the body weight. The animals were divided into five groups as control, saline (1 ml/kg/day olive oil for 30 days), Wi-Fi (12 h/day for 30 days), melatonin (10 mg/kg/day for 30 days) and melatonin + Wi-Fi (10 mg/kg/day +12 h/day for 30 days). In the thirtieth day, thirty minutes after the last drugs administration at the indicated doses, PTZ in 45 mg/kg was administered to induce epileptic seizure. The animals were observed for 30 min during the seizure stages (according to the Racine Scale) and first myoclonic jerk times (FMJ). Twenty-four hours after PTZ injection, brain tissues were removed for biochemical and histopathological evaluation. The hippocampal Cornu Ammonis (CA) 1, CA3 and DG (dentate gyrus) regions were histopathologically evaluated in terms of a neuronal damage in addition that oxidative stress markers (total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI)) were measured in brain tissues.Wi-Fi was not found to affect behavioral changes associated with epilepsy (p > 0.05). However, Wi-Fi reduced anticonvulsive and antioxidant effect of melatonin (p < 0.05). Moreover, Wi-Fi increased neuronal damage in hippocampus (p < 0.05).Wi-Fi did not directly affect epileptic seizures. Nevertheless, it inhibits the positive effects of melatonin on epilepsy and it also has negative effects on hippocampal neuronal damage. These effects of Wi-Fi may occur via oxidative pathways.

10.1016/j.pathophys.2019.11.003

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Citations (18)

Mercury leads to abnormal red blood cell adhesion to laminin mediated by membrane sulfatides

Biochimica et Biophysica Acta (BBA) - Biomembranes (2019)

Birnur Akkaya Erdem Kucukal Jane A. Little Umut A. Gürkan

Mercury

10.1016/j.bbamem.2019.03.008

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Citations (14)

Modification by natural sources to reduce immuno-reactivity of milk proteins

Cumhuriyet Science Journal (2020)

Recep Akkaya Birnur Akkaya Serap Çetinkaya

The main aim of the current study was to reduce the IgE-binding capacity of cow’s milk through its chemical modification by natural source treatment. The presence of children allergic responses to cow's milk has become a growing concern in the world. A possible approach to reduce protein allergen is to block IgE-binding epitopes of protein allergen by various methods. One of them is protein glycation. We wanted to examine effect of some additives especially lemon juices on milk protein modification by using electrophoresis and 2D gel electrophoresis. As a result of this study lemon juice (ascorbic acid) enhanced glycation of milk proteins.

10.17776/csj.657593

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Separation of lysozyme with magnetically stabilized spherical hydroxyapatite microcomposites in a continuous flow system

Journal of Applied Polymer Science (2013)

Birnur Akkaya

ABSTRACT The aim of this study was to produce a spherical and magnetic hydroxyapatite (HA) microcomposite to use as an adsorbent for the separation of lysozyme in a magnetically stabilized fluidized bed and to separate lysozyme from a protein mixture composed of human immunoglobulin G, human serum albumin, and lysozyme. For this purpose, spherical and magnetic HA microcomposites (50–100 μm) were synthesized by suspension polymerization and characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, scanning electron microscopy, electron spin resonance, vibrating‐sample magnetometry, Brunauer–Emmett–Teller analysis, and a swelling test. The specific surface areas of the pure HA and magnetic HA microcomposite were determined to be 72.25 and 151.53 m 2 /g, respectively. The swelling ratio of the spherical HA microcomposites was 150%. Adsorption experiments were conducted under conditions that differed in terms of pH, temperature, ionic strength, flow velocity, and magnetic field. According to the findings of the adsorption kinetic studies, the adsorption process was appropriate to pseudo‐first‐order kinetics. The separation of the lysozyme from the protein mixture was achieved by means of a 50 m M pH 7.0 phosphate buffer. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 1602–1610, 2013

Specific surface area

10.1002/app.39289

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Citations (7)

Drug delivery behavior of magnetic composite: In vitro study

Bangladesh Journal of Medical Science (2024)

Birnur Akkaya Beyza Nur Yerliyurt

Background One method for delivering the medication to the intended location and achieving the desired therapeutic effect is controlled drug release. Compared to typical release systems, controlled medication release systems offer fewer potential adverse effects and can increase patient comfort by prolonging the time intervals between drug intakes. Expanded perlite modified composite were used as drug carrier materials in the current investigation because of its excellent adsorption capability. Aim: Using magnetic poly(hydroxyethylmethacrylate-expanded perlite) (m-p(hema-ep)) composite material, doxorubicin release was examined in this work. Methodolgy First, a magnetic p(hema-ep) composite was created for this purpose and examined using SEM, FTIR, and swelling tests. The medication doxorubicin served as a model. Tests for reusability were conducted. The synthesized magnetic p(hema-ep) composite was shown to be capable of being recycled ten times without losing effectiveness. On the C6 cell line, the material and the material that had been loaded with doxorubicin were subjected to cytotoxicity tests under magnetic field. Results The impacts of variables like pH, time, temperature, on drug release were examined as a consequence of the characterisation procedure. The ideal release parameters were found to be 80% release at pH 4.5, 70% release is seen at 7.4, and temperature 22 °C, under magnetic field. Conclusion: The anti-cancer medication doxorubicin (Dox) was used as a model drug because it is widely used in cancer treatment and is simple to quantify using methods like UV-visible spectroscopy. There are enhanced doxorubicin release under magnetic field. Bangladesh Journal of Medical Science Vol. 23 No. 03 July’24 Page : 666-675

10.3329/bjms.v23i3.75022

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Cross-Linked Bentonite-Acrylamide-histidine-Based Metal-Chelate Affinity Microcomposites for Lysozyme Separation From Egg White

Separation Science and Technology (2012)

Birnur Akkaya Recep Akkaya

Among different adsorbents, a new support for immobilized metal affinity chromatography was used for lysozyme separation from egg white. For this purpose, acrylamide, bisacrylamide, bentonite, and L-histidine in the presence of an initiator (azobisisobutyronitrile, AIBN) were mixed and bentonite-acrylamide-histidine microcomposites were prepared by bulk polymerization. Characterization studies were performed by SEM, FT-IR, XRD, and BET. Specific surface area of the bentonite and BABH microcomposite was found to be 33.4 and 1.42 m2/g, respectively. Cu2+ ions (20 µmol/g) were chelated on these bentonite-acrylamide-histidine (50 µmol/g L-histidine incorporation) microcomposites. The lysozyme adsorption capacity of the Cu2+ ions chelated microcomposites increased the lysozyme adsorption up to 100 mg/g while the lysozyme adsorption capacity of the bentonite-acrylamide-histidine was 24 mg/g. More than 89% of the adsorbed lysozyme was desorbed in 1 h in the desorption medium containing 1.0 M NaCl. Bentonite-acrylamide-histidine-Cu(II) was used for the purification of lysozyme from chicken egg white. The purity of lysozyme was estimated by SDS-PAGE. Specific activity of the purified lysozyme was found as 50,000 U/mg using Micrococcus lysodeikticus as substrate. The new metal-chelate affinity microcomposites were suitable for repeated use for five cycles without a noticeable loss of capacity.

Bentonite

10.1080/01496395.2012.683124

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Citations (2)