Núria Ruiz

Bellvitge University Hospital

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Artur Mezheyeuski

Vall d'Hebron Institute of Oncology

A Graterol

Hospital Vargas

Leopoldo Brizuela

Hospital Vargas

Laura Lladó

Bellvitge University Hospital

Guillermo Veitía

Hospital Vargas

Xavier Matías‐Guiu

Centro de Investigación Biomédica en Red de Cáncer

David G. Mollevı́

Institut d'Investigació Biomédica de Bellvitge

Gemma Garcia‐Vicién

Institut d'Investigació Biomédica de Bellvitge

Patrick Micke

Uppsala University

Domingo Barettino

Instituto de Biomedicina de Valencia

Cooperative Institutions

Institut d'Investigació Biomédica de Bellvitge

Institut Català d'Oncologia

Bellvitge University Hospital

Universitat de Barcelona

Duran i Reynals Hospital

Universitat Autònoma de Barcelona

Centro de Investigación Biomédica en Red de Cáncer

Ajuntament de L’Hospitalet

Institut Català d'Ornitologia

Hospital Universitari Germans Trias i Pujol

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501P Spatial immunology in colorectal liver metastases

Annals of Oncology (2020)

Gemma Garcia‐Vicién Artur Mezheyeuski Patrick Micke Núria Ruiz David G. Mollevı́

Infiltration (HVAC)

Parenchyma

Immunophenotyping

10.1016/j.annonc.2020.08.611

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Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern

Cancers (2022)

Gemma Garcia‐Vicién Artur Mezheyeuski Patrick Micke Núria Ruiz J.C. Ruffinelli

Colorectal cancer liver metastases (CRC-LM) present differential histologic growth patterns (HGP) that determine the interaction between immune and tumor cells. We explored the spatial distribution of lymphocytic infiltrates in CRC-LM in the context of the HGP using multispectral digital pathology. We did not find statistically significant differences of immune cell densities in the central regions of desmoplastic (dHGP) and non-desmoplastic (ndHGP) metastases. The spatial evaluation reported that dHGP-metastases displayed higher infiltration by CD8+ and CD20+ cells in peripheral regions as well as CD4+ and CD45RO+ cells in ndHGP-metastases. However, the reactive stroma regions at the invasive margin (IM) of ndHGP-metastases displayed higher density of CD4+, CD20+, and CD45RO+ cells. The antitumor status of the TIL infiltrates measured as CD8/CD4 reported higher values in the IM of encapsulated metastases up to 400 μm towards the tumor center (p < 0.05). Remarkably, the IM of dHGP-metastases was characterized by higher infiltration of CD8+ cells in the epithelial compartment parameter assessed with the ratio CD8epithelial/CD8stromal, suggesting anti-tumoral activity in the encapsulating lesions. Taking together, the amount of CD8+ cells is comparable in the IM of both HGP metastases types. However, in dHGP-metastases some cytotoxic cells reach the tumor nests while remaining retained in the stromal areas in ndHGP-metastases.

Infiltration (HVAC)

10.3390/cancers14030689

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Citations (7)

P-317 Survival outcomes among patients with locally advanced esophageal cancer treated within a multidisciplinary gastro-esophageal cancer functional unit

Annals of Oncology (2020)

A. Plaja Salarich A. Ferrando Díez C. Bugés Sánchez C. Hierro Carbó M. Caro Gallarín

Carboplatin

Performance status

Multimodal therapy

10.1016/j.annonc.2020.04.399

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Environmental exposure to pesticides is associated with oxidative stress, oxidative DNA damage, and elevated interleukin-8 in a child population.

Environmental Toxicology and Pharmacology (2025)

José Antonio Aguilar-Bañuelos Yael Yvette Bernal-Hernández Irma Martha Medina‐Díaz Miguel Alfonso Ruíz-Arias José Francisco Herrera‐Moreno

10.1016/j.etap.2025.104656

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Single cell transcriptomic analysis of Graves’ disease thyroid glands reveals the broad immunoregulatory potential of thyroid follicular and stromal cells and implies a major re-interpretation of the role of aberrant HLA class II expression in autoimmunity

Journal of Autoimmunity (2023)

Daniel Álvarez‐Sierra Jorge Rodríguez-Grande Aroa Gómez Irene Bello Enric Caubet

Immune privilege

10.1016/j.jaut.2023.103072

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Citations (5)

Consumo de tabaco y alcohol en pacientes con cáncer esofágico y su relación con el tipo histológico: Hospital Vargas de Caracas período 2004 - 2009

Gen (2010)

Guillermo Veitía J. Otero Núria Ruiz A Graterol Leopoldo Brizuela

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Consumo de alcohol en los pacientes que acudieron por consulta externa del Hospital Vargas de Caracas durante el período Marzo - Mayo 2008

Gen (2009)

Arianna Marelli Leopoldo Brizuela Diana D. del Valle E Mago Armas

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Estudio de la expresión génica durante la diferenciaciónde células de neuroblastoma SH-SY5Y inducida con Acido Retinoico

Salvador Meseguer Núria Ruiz Domingo Barettino

Poster original, presentado al XXXI Congreso de la Sociedad Espanola de Bioquimica y Biologia Molecular. Bilbao, del 10 al 13 de Septiembre de 2008.

SH-SY5Y

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Can medical imaging identify the histopathological growth patterns of liver metastases?

Seminars in Cancer Biology (2020)

Emily Latacz Pieter‐Jan van Dam Christian Vanhove Laura Lladó Benedicte Descamps

Liver Cancer

10.1016/j.semcancer.2020.07.002

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Citations (32)

Study of late toxicity biomarkers of locally advanced head and neck cancer patients treated with radiotherapy plus cisplatin or cetuximab points to the relevance of skin macrophages (TOX-TTCC-2015-01)

Clinical & Translational Oncology (2024)

Antonio Rullan Juan A. Marín‐Jiménez A. Lozano Oriol Bermejo Lorena Arribas

Abstract Purpose Radiotherapy (RT) with concomitant cisplatin (CRT) or cetuximab (ERT) are accepted treatment options for locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). Long-term adverse events (AEs) have a vast impact on patients’ quality of life. This study explored tissue biomarkers which could help predict late toxicity. Methods/patients Single-institution prospective study including patients aged ≥ 18 with histologically confirmed newly diagnosed LA-SCCHN treated with RT and either concomitant cisplatin q3w or weekly cetuximab, according to institutional protocols. All patients underwent pre- and post-treatment skin biopsies of neck regions included in the clinical target volume. Angiogenesis, macrophages, and extracellular matrix (ECM) markers were evaluated by immunohistochemistry (IHC). Results From April 15, 2016, to December 11, 2017; 31 patients were evaluated [CRT = 12 (38.7%) and ERT = 19 (61.3%)]. 27 patients (87%) had received induction chemotherapy. All patients finished RT as planned. IHC expression of vasculature (CD34) and collagen (Masson’s Trichrome) did not differ significantly between and within CRT and ERT arms. Conversely, an increased CD68 and CD163 macrophage infiltration expression was observed after treatment, without significant impact of treatment modality. Patients with higher late toxicity showed lower expression of macrophage markers in pre-treatment samples compared with those with lower late toxicity, with statistically significant differences for CD68. Conclusions Angiogenesis and ECM biomarkers did not differ significantly between CRT and ERT. Macrophage markers increased after both treatments and deserve further investigation as predictors of late toxicity in LA-SCCHN patients. [Protocol code: TOX-TTCC-2015-01/Spanish registry of clinical studies (REec): 2015-003012-21/Date of registration: 27/01/2016].

Concomitant

CD68

Chemoradiotherapy

10.1007/s12094-024-03526-0

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