Our research compares and contrasts the transnational activism of maritime unions in Australia and the United States in what became the first and longest example of global solidarity in the post-World War II era – the anti-apartheid movement. Dockworkers, with a deep history of solidarity, occupied a strategic position to exert real influence on the South African state by refusing to unload South African cargo. We analyze the actions of the Waterside Workers' Federation (WWF) in Australia and the International Longshore and Warehouse Union (ILWU) in the US, namely by exploring notions of solidarity and political unionism among marine transport workers, ideological motivations for solidarity activism, ethnic and race relations among workers, and labor connections these maritime unions made beyond the waterfront. We find and account for similarities and differences in Australian and US labor activism that often is underrepresented and incompletely explained in the literature.
Streptococcus pneumoniae is the most common cause of community-acquired pneumonia, and pneumolysin, a hemolytic toxin, is thought to be an important virulence factor. We have studied the interaction of a pneumolysin-sufficient type II S. pneumoniae strain (PL+) and an otherwise identical pneumolysin-deficient derivative (PL-) with human respiratory mucosa in an organ culture with an air interface for up to 48 h. Ciliary beat frequency (CBF) was measured by a photometric technique, and adherence to and invasion of the epithelium were assessed by scanning and transmission electron microscopy. PL+ and PL- caused a progressive fall in CBF compared with the control which became significant (P < 0.01) at 24 h for PL+ and at 48 h for PL-. At 24 h, there was a significant increase in the percentage of the mucosa of the organ culture that was damaged for PL+ compared with the control (P < 0.01) and PL- (P < 0.02). At 48 h, there was a significant increase in mucosal damage for both PL+ (P < 0.005) and PL- (P < 0.05) compared with the control. At 24 and 48 h, PL+ and PL- adhered predominantly to mucus and damaged cells. PL+ infection alone caused separation of tight junctions between epithelial cells, and at 48 h PL+ cells were adherent to the separated edges of otherwise healthy unciliated cells. PL+ and PL- both caused damage to the epithelial cell ultrastructure. S. pneumoniae infection caused patchy damage to the respiratory mucosa and a lowered CBF. These changes were more severe and occurred earlier with the pneumolysin-sufficient variant.
It has been suggested that proteinase enzymes could play an important role in the pathogenesis of chronic bronchial infections including bronchiectasis and cystic fibrosis (CF). Because Pseudomonas aeruginosa frequently colonizes the respiratory tract in bronchiectasis and CF, we examined the in vitro effects of human neutrophil elastase (HNE) and proteinase enzymes produced by P. aeruginosa (elastase: PE; alkaline proteinase: PAP) on the ciliary beat frequency (CBF) and ultrastructure of human nasal ciliated respiratory epithelium.HNE (500 µg/ml) progressively reduced CBF and caused marked epithelial disruption; lower concentrations (100 and 20 µg/ml) also caused epithelial disruption but without slowing CBF. The effects of HNE (500 µg/ml) were completely abolished by adding α1-antitrypsin (5 mg/ml). There was no synergy between HNE and pyocyanin, a product of P. aeruginosa which slows CBF. PE in phosphate-buffered saline also caused epithelial disruption without slowing CBF; however, PE in medium containing divalent metal ions caused CBF slowing as well as epithelial disruption at 100 µg/ml. PAP (500 µg/ml) had almost no effect on ciliated epithelium. The effects of HNE and PE on nasal and bronchial epithelium obtained from the same patient were similar. Light and transmission electron microscopy revealed that HNE and PE were cytotoxic and caused detachment of epithelial cells from neighboring cells and the basement membrane. There was cytoplasmic blebbing of the cell surface and mitochondrial damage; however, no increase of abnormalities in the ultrastructure of cilia on living cells was seen. These results support the hypothesis that HNE and PE contribute to the delayed mucociliary clearance and epithelial damage that is observed in patients with chronic bronchial infection.
Julian Brown's thoughtful book is chock-full of insights while still under 200 pages of text. Brown convincingly argues that the notion of a so-called ‘quiet decade’, from the early 1960s until the...
First Nations tricksters, Coyote and Raven, work to indigenize Environmental Education but run up against mainstream languages, technologies, and educational practices. They try to do an end-run around the cognitive backfield, then portage through marginal spaces, but find that working between Indigenous languages and mainstream ones can work best by being conversational and bringing in humour and ways of knowing that do not only privilege post-Enlightenment agency but use understandings that gesture toward localized Indigenous practices and changing West Coast (Canada) geographies.
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