M. Huber

Heidelberg University

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Veit Krenn

Zentrum für Pathologie und Zytodiagnostik

F. Lintner

Otto Wagner Hospital

M. Thomsen

Klinikum Mittelbaden

W. Rüther

Universität Hamburg

Giorgio Perino

Universitätsmedizin Greifswald

Friedrich Boettner

Hospital for Special Surgery

Daniel Kendoff

Helios Hospital Berlin-Buch

Manfred Georg Krukemeyer

Paracelsus-Kliniken

Jan Philippe Kretzer

University Hospital Heidelberg

P. Thomas

Rutgers, The State University of New Jersey

Cooperative Institutions

Medical University of Vienna

University of Vienna

Universitäts Frauenklinik

Universitätsklinik für Frauenheilkunde und Geburtshilfe

Heidelberg University

Vienna General Hospital

Ludwig-Maximilians-Universität München

Klinik für Frauenheilkunde

Charité - Universitätsmedizin Berlin

Krebsregister Saarland

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Measurements of biophysical cellular parameters in mammalian cells after gamma- and alpha-irradiation

Friedrich Steinhäusler Peter Eckl B. Reubel Wilhelm Heidegger M. Huber

Alpha (finance)

Gamma Irradiation

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Histopathologische Diagnostik von Gelenkendoprothesen-assoziierten Erkrankungen

Der Hautarzt (2016)

Veit Krenn Giorgio Perino Veit Krenn Stephan Wienert Darius Saberi

10.1007/s00105-016-3778-2

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Citations (7)

Ewing’s Sarcoma and Peripheral Primitive Neuroectodermal Tumor in Adults: Different Features of a Rare Neoplasm

Onkologie (2008)

Christine Armbruster M. Huber Helmut Prosch Nina Dworan Johannes Attems

Introduction: In adults, peripheral primitive neuroectodermal tumors (pPNETs) represent a rare and heterogeneous group of neoplasms exhibiting neuronal and glial differentiation. Patients and Methods: We present the clinicopathologic features of four examples of the Ewing's sarcoma (EWS)/pPNET group in adults. Hematoxylin and eosin staining, immunohistochemical and molecular studies were reviewed in every case. Immunohistochemical stains were performed on formalin-fixed, paraffin-embedded sections, molecular studies were done using fluorescence in situ hybridization (FISH). Results: Three patients presented with tumors of the thoracopulmonary region, one patient showed EWS of the soft tissue. Microscopically, tumor tissue was composed of round, small, blue cells with fine granular chromatin texture and inconspicuous nucleoli. Mitotic figures and rosettes were present. Tumor cells strongly coexpressed CD99 and vimentin, but due to technical reasons t(22q12) translocation studies proved the presumptive diagnosis of EWS/pPNET in one case only. Despite similar multimodality treatment survival time ranged from 6 to 42 months, two patients were alive at the time of reporting. Conclusions: As tumors of the EWS/pPNET family behave aggressively, rapid diagnosis is warranted. Since diagnosis of EWS/pPNET requires ancillary studies, it is necessary to consider it even in adult patients.

CD99

Primitive neuroectodermal tumor

Ewing's sarcoma

Neuroectodermal tumor

10.1159/000118034

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Citations (15)

Revisionsendoprothetik

Der Orthopäde (2015)

V. Krenn Benny Kölbel M. Huber A. Tiemann Daniel Kendoff

10.1007/s00132-015-3083-2

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Citations (2)

Erweiterte Konsensusklassifikation

Veit Krenn Lars Morawietz H. Kienapfel R. Ascherl Georg Matziolis

10.1007/s00393-012-1099-0

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Citations (45)

Lung disease 35 years after aspiration of activated charcoal in combination with pulmonary lymphangioleiomyomatosis

Virchows Archiv (2006)

M. Huber Wolfgang Pohl Georg Reinisch Johannes Attems S. Pescosta

Activated Charcoal

Charcoal

Lymphangioleiomyomatosis

10.1007/s00428-006-0236-z

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Citations (7)

[Correlation of neuroradiologic and pathologico-anatomic findings in a case of multiple sclerosis].

PubMed (1987)

H. Bewermeyer M. Huber G. Ebhardt

Source

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Citations (2)

Meetings and Conferences · Tagungen und Kongresse

Oncology Research and Treatment (2000)

J. Behrens Gabriele Schackert Stephan B. Sobottka A. Steinmetz M Kirsch

10.1159/000027095

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[Revision arthroplasty : Histopathological diagnostics in periprosthetic joint infections].

Der Orthopäde (2015)

Кренн Benny Kölbel M. Huber A. Tiemann Daniel Kendoff

Histopathology

Histopathological examination

Arthrofibrosis

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Citations (1)

Nα-acetyltransferase NAA50 mediates plant immunity independent of the Nα-acetyltransferase A complex

PLANT PHYSIOLOGY (2024)

Laura Armbruster Marlena Pożoga Zhongshou Wu Jürgen Eirich Karen Thulasi Devendrakumar

In humans and plants, 40% of the proteome is cotranslationally acetylated at the N-terminus by a single Nα-acetyltransferase (Nat) termed NatA. The core NatA complex is comprised of the catalytic subunit Nα-acetyltransferase 10 (NAA10) and the ribosome-anchoring subunit NAA15. The regulatory subunit Huntingtin Yeast Partner K (HYPK) and the acetyltransferase NAA50 join this complex in humans. Even though both are conserved in Arabidopsis (Arabidopsis thaliana), only AtHYPK is known to interact with AtNatA. Here we uncover the AtNAA50 interactome and provide evidence for the association of AtNAA50 with NatA at ribosomes. In agreement with the latter, a split-luciferase approach demonstrated close proximity of AtNAA50 and AtNatA in planta. Despite their interaction, AtNatA/HYPK and AtNAA50 exerted different functions in vivo. Unlike NatA/HYPK, AtNAA50 did not modulate drought tolerance or promote protein stability. Instead, transcriptome and proteome analyses of a novel AtNAA50-depleted mutant (amiNAA50) implied that AtNAA50 negatively regulates plant immunity. Indeed, amiNAA50 plants exhibited enhanced resistance to oomycetes and bacterial pathogens. In contrast to what was observed in NatA-depleted mutants, this resistance was independent of an accumulation of salicylic acid prior to pathogen exposure. Our study dissects the in vivo function of the NatA interactors HYPK and NAA50 and uncovers NatA-independent roles for NAA50 in plants.

Acetyltransferases

Proteome

10.1093/plphys/kiae200

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Citations (1)