Wentao Han

Washington University in St. Louis

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Grant A. Challen

Washington University in St. Louis

Hassan Bjeije

Washington University in St. Louis

Andrew L. Young

Washington University in St. Louis

Nancy Issa

Washington University in St. Louis

Christine Zhang

New York City Health and Hospitals Corporation

Won Kyun Koh

Washington University in St. Louis

Saranajith Dunuwille

Washington University in St. Louis

Infencia Xavier Raj

Washington University in St. Louis

Tyler M. Parsons

Washington University in St. Louis

Songqing Li

South China University of Technology

Cooperative Institutions

Washington University in St. Louis

Beijing Forestry University

Incyte (United States)

The University of Texas Southwestern Medical Center

University of Michigan–Ann Arbor

Huazhong University of Science and Technology

University of California, San Francisco

University of Chinese Academy of Sciences

Chinese Academy of Sciences

University of Hong Kong

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EZH2-Mediated Methylation Regulates JARID2 Protein Stability in Normal and Neoplastic Hematopoiesis

Blood (2024)

Hassan Bjeije Wentao Han Hamza Celik Yanan Li Michael P. Rettig

10.1182/blood-2024-202827

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Citations (0)

Seasonal changes of androgen receptor, estrogen receptors and aromatase expression in the hippocampus of the wild male ground squirrels ( Citellus dauricus Brandt)

General and Comparative Endocrinology (2017)

Fengwei Zhang Yu Wang Wentao Han Junjie Wang Haolin Zhang

Hibernation

10.1016/j.ygcen.2017.05.009

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Citations (11)

Dnmt3a Loss-of-Function Enhances DNA Repair in Proliferative HSCs Under Inflammatory Stress

Blood (2022)

Christine Zhang Jason Arand Wentao Han Infencia Xavier Raj Saranajith Dunuwille

10.1182/blood-2022-167238

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Citations (1)

A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms

Cancer Discovery (2021)

Hamza Celik Ethan Krug Christine Zhang Wentao Han Nancy Issa

Abstract Myeloproliferative neoplasms (MPN) are chronic blood diseases with significant morbidity and mortality. Although sequencing studies have elucidated the genetic mutations that drive these diseases, MPNs remain largely incurable with a significant proportion of patients progressing to rapidly fatal secondary acute myeloid leukemia (sAML). Therapeutic discovery has been hampered by the inability of genetically engineered mouse models to generate key human pathologies such as bone marrow fibrosis. To circumvent these limitations, here we present a humanized animal model of myelofibrosis (MF) patient-derived xenografts (PDX). These PDXs robustly engrafted patient cells that recapitulated the patient's genetic hierarchy and pathologies such as reticulin fibrosis and propagation of MPN-initiating stem cells. The model can select for engraftment of rare leukemic subclones to identify patients with MF at risk for sAML transformation and can be used as a platform for genetic target validation and therapeutic discovery. We present a novel but generalizable model to study human MPN biology. Significance: Although the genetic events driving MPNs are well defined, therapeutic discovery has been hampered by the inability of murine models to replicate key patient pathologies. Here, we present a PDX system to model human myelofibrosis that reproduces human pathologies and is amenable to genetic and pharmacologic manipulation. This article is highlighted in the In This Issue feature, p. 2945

Humanized mouse

Ruxolitinib

10.1158/2159-8290.cd-20-1652

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Citations (19)

Flexible dispersive liquid–liquid microextraction for on-site sample pre-concentration

International Journal of Environmental & Analytical Chemistry (2019)

Songqing Li Wentao Han Wanning Zhao Youqing Luo

In recent years, more and more interest has been focused on the on-site sample preparation. Dispersive liquid–liquid microextractions without centrifugation or toxic organic solvent were developed ...

Liquid liquid

Sample (material)

Solid-Phase Microextraction

Sample Preparation

10.1080/03067319.2019.1665654

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Citations (3)

DNMT3A Mutations Enhance T-ALL Survival, Which Is Reversed By JAK/STAT Inhibition

Blood (2022)

Wangisa M.B. Dunuwille William Casey Wilson Nancy Issa Won Kyun Koh Wentao Han

10.1182/blood-2022-167136

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Citations (0)

In Vivo and Ex Vivo Expansion of Functional Human Repopulating Cells through JARID2 Inhibition

Blood (2024)

Wentao Han Hassan Bjeije Hamza Celik Michael P. Rettig Yanan Li

Ex vivo

10.1182/blood-2024-211397

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Seasonal expression of P450c17 and 5α-reductase-2 in the scented gland of male muskrats (Ondatra zibethicus)

General and Comparative Endocrinology (2017)

Wentao Han Wenqian Xie Yan Zhang Fengwei Zhang Haolin Zhang

Dihydrotestosterone

Scent gland

10.1016/j.ygcen.2017.09.015

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Citations (16)

A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms

bioRxiv (Cold Spring Harbor Laboratory) (2020)

Hamza Celik Ethan Krug Christine RC Zhang Wentao Han Nancy Issa

ABSTRACT Myeloproliferative neoplasms (MPNs) are chronic blood diseases with significant morbidity and mortality. While sequencing studies have elucidated the genetic mutations that drive these diseases, MPNs remain largely incurable with a significant proportion of patients progressing to rapidly fatal secondary acute myeloid leukemia (sAML). Therapeutic discovery has been hampered by the inability of genetically-engineered mouse models to generate key human pathologies such as bone marrow fibrosis. To circumvent these limitations, here we present a humanized animal model of myelofibrosis (MF) patient-derived xenografts (PDXs). These PDXs robustly engrafted patient cells which recapitulated the patient’s genetic hierarchy and pathologies such as reticulin fibrosis and propagation of MPN-initiating stem cells. The model can select for engraftment of rare leukemic subclones to identify MF patients at-risk for sAML transformation, and can be used as a platform for genetic target validation and therapeutic discovery. We present a novel but generalizable model to study human MPN biology. STATEMENT OF SIGNIFICANCE Although the genetic events driving myeloproliferative neoplasms (MPNs) are well-defined, therapeutic discovery has been hampered by the inability of murine models to replicate key patient pathologies. Here, we present a patient-derived xenograft (PDX) system to model human myelofibrosis that reproduces human pathologies and is amenable to genetic and pharmacological manipulation.

Humanized mouse

Myeloproliferative neoplasm

10.1101/2020.11.12.378810

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Citations (4)

BIRC5 Upregulation Enhances DNMT3A-Mutant T-ALL Cell Survival and Pathogenesis

Deleted Journal (2024)

Wangisa M.B. Dunuwille William C. Wilson Hassan Bjeije Nancy Issa Wentao Han

Pathogenesis

10.1016/j.bneo.2024.100040

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Citations (0)