A numerical study is performed to demonstrate the thermomagnetic convection of air in a side-wall heated enclosure under constant gravity and time-periodic magnetizing force formed by current with sinusoidal waveform. Two cases have been considered: electric coil is located at the right side of the enclosure in case 1, and in case 2 the electric coil is below the enclosure. The spectral element method is applied to obtain the numerical solutions from the time-dependent Navier-Stokes equations including the magnetizing force term. The computed results show the existence of resonance, which is characterized by the maximum fluctuation of heat transfer in the interior. And the resonance phenomenon becomes more distinctive as Ra increases. Details of fluid flow and heat transfer under resonance is scrutinized by examining the evolution of oscillating components. The results indicate that case 1 exhibits advantages in using resonance to enhance the heat transfer rate, where a smaller magnetic strength is employed to simultaneously obtain larger fluctuations of fluid flow and heat transfer.
The combustion characteristics of premixed methane-air flames in a half-open tube with a two-sided 45° branch structure at different ignition positions were investigated by experiments and large eddy simulations. The numerical results were compared with the experimental results to verify the correctness of the model. The results show that the simulation results are highly consistent with the experiment. This study provides a basic understanding of the effects of the branch tube structure and the ignition position on flame dynamics. When the flame propagates to the branch interface, it forms a symmetrical vortex structure at the branch tube with the opposite rotation direction. When the ignition position is at IP0 and IP900, the maximum overpressures obtained in the experiment are 10.1 and 10.7 kPa, respectively, and 9.2 and 10.4 kPa in the simulation, respectively. At IP0, the Karlovitz number indicating the interaction intensity between the flame surface and the turbulence during flame propagation is a maximum of 9.2 and a minimum of 0.04. The premixed flame has a folded small flame, a corrugated small flame, and a thin reaction zone.
Garbage and biomass contain more chlorine, which reacts with H2 to form HCl gas during combustion or gasification, resulting in corrosion of metal walls. In this paper, based on the chlorine mechanism in Ansys Chemkin-Pro, the laminar combustion characteristics of H2/Cl2 are simulated with different diluents CO2/N2 under an initial temperature of 298 K, equivalence ratio range of 0.6-1.4, and initial pressure of 0.1-0.5 MPa. The results show that the laminar burning velocity of H2/Cl2 decreases significantly with the increase of dilution gas ratio, and the effect of diluent CO2 is more significant than that of N2. Due to the dilution effect, the fuel and oxidation components are reduced. Through sensitivity analysis, reaction R2: Cl + H2 = HCl + H is the main reaction of HCl formation. On improving the initial pressure, the laminar burning velocity is slightly lowered, and the thermal diffusivity of the fuel mixture increases with the increase of the initial pressure. According to the sensitivity analysis of the velocity, reactions R2, R9, and R10 are the main reactions that affect the laminar burning velocity, and the product HCl will be generated with a delay with the increase of the initial pressure.
Analysis of drag reduction effects due to axial oscillation of an inner cylinder in a turbulent Taylor–Couette (TC) flow is performed in the present study. The frictional Reynolds number on the inner cylinder is 218, and the non-dimensional oscillating period is varied from 8 to 32. By examining turbulence statistics, we uncover different impacts of the long- and short-period oscillations on the circumferential (θ) and radial (r) velocity fluctuations in large (uθl, url) and small (uθs, urs) scales. One of the most surprising findings is that the short-period oscillation increases the large-scale Reynolds shear stress ⟨uθlurl⟩ by the strong intensification of uθl exceeding the suppression of url. To understand the phenomena, the spectra of each term in the transport equations of the Reynolds normal stresses ⟨uθ′uθ′⟩ and ⟨ur′ur′⟩ are analyzed. First, it is shown that the short-period oscillation weakens the productions of uθs, urs, and url while it enhances that of uθl. In contrast, the long-period oscillation reduces the productions of uθl and url while it mainly intensifies that of urs. Second, the investigations of the pressure–strain terms indicate that the short-period oscillation mainly impedes the inter-component energy transfer originating from the small-scale background turbulence. However, the long-period oscillation benefits the small-scale inter-component energy communication while it hinders the large-scale one. In addition, the inverse energy transfer in the turbulent TC flow is confirmed by inspecting the inter-scale energy transfer terms. The hindrance of the inter-scale energy transfer by the inner-cylinder oscillation plays a non-negligible role in the reduction of the wall friction drag.
BackgroundPlatinum-doublet chemotherapy plus immunotherapy has been the standard of care for the first-line treatment of advanced non-small cell lung cancer lacking actional driver mutations. However, optimization of drug combinations is still needed to find a better balance between therapeutic efficacy and safety in the immunotherapy era. We aimed to investigate the efficacy and safety of platinum-free albumin bound paclitaxel (nab-paclitaxel) combined with camrelizumab and apatinib as first-line treatment for patients with advanced lung adenocarcinoma.MethodsIn this multicenter open-label, single-arm phase II trial, patients with systemic treatment-naïve advanced lung adenocarcinoma without epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) mutations received a rational-based combination of camrelizumab (200 mg intravenously, day one), apatinib (250 mg, q.d., five continuous days per week), and nab-paclitaxel (135 mg/m2 intravenously, days one and eight) every three weeks for four to six cycles in China. Patients with controlled disease were maintained with camrelizumab and apatinib. The primary end point was progression-free survival (PFS). This trial is registered with ClinicalTrials.gov (No. NCT04459078).FindingsBetween August 26, 2020 and May 20, 2022, 64 patients were enrolled. The median PFS was 14.3 (95% CI: 9.9, not reached) months. The confirmed objective response rate was 64.1% (95% CI: 51.1, 75.7). The grade 3–4 hematologic treatment-related adverse events (TRAEs) were decreased neutrophil count (14.1%), decreased white blood cell count (7.8%), and anemia (3.1%). The most common non-hematologic TRAEs of grade 3–4 were increased alanine transaminase (18.8%) and aspartate transaminase (15.6%). No treatment-related death occurred. The quality of life was on average not clinically meaningful worse through treatment cycle 14.InterpretationNab-paclitaxel plus camrelizumab and apatinib showed clinically meaningful anti-tumor activity and manageable safety, with few hematologic toxicities, and might be a potential treatment option in patients with advanced lung adenocarcinoma lacking EGFR/ALK mutations.FundingHeath Research Foundation of Chinese Society of Clinical Oncology, Hunan Provincial Natural Science Foundation of China, Hunan Cancer Hospital Climb Plan, Sister Institution Network Fund of The University of Texas MD Anderson Cancer Center, The Science and Technology Innovation Program of Hunan Province, and Suzhou Sheng Diya Biomedical Co., Ltd, a subsidiary of Jiangsu Hengrui Pharmaceuticals Co., Ltd. (Shanghai, China).
e20534 Background: While tumor genotyping is the standard treatment for patients with non-small cell lung cancer (NSCLC), spatial and temporal tumor heterogeneity and insufficient specimens can lead to limitations in the use of tissue-based sequencing. Circulating tumor DNA (ctDNA) fully encompasses tumor-specific sequence alterations and offers an alternative to tissue sample biopsies. The aim of the study was to evaluate whether the frequency of multiple genomic alterations observed following ctDNA sequencing was similar to that observed following tissue sequencing in NSCLC. Methods: A total of 99 NSCLC patients were enrolled in this study, including 40 tissue and 59 plasma samples. All kinds of variants of oncogenic drivers in NSCLC were identified by next-generation sequencing (NGS) with Acornmed panel. Results: The frequencies of genetic alterations detected in ctDNA were significantly correlated to those detected via tissue profiling (Spearman’s r = 0.812, P = 0.022). Genomic data revealed significant mutual exclusivity between alterations in epidermal growth factor receptor ( EGFR) and tumor protein 53 ( TP53; P = 0.020) and between those in EGFR and Kirsten rat sarcoma viral oncogene homolog ( KRAS; P = 0.008), as well as potential mutual exclusivity between alterations in EGFR and Erb-B2 receptor tyrosine kinase 2 ( ERBB2; P = 0.059). Furthermore, the EGFR mutant allele frequency (MAF) was strongly correlated with the TP53 MAF in individual tumors (Spearman’s r = 0.773, P = 0.005), and there was a marked difference in the EGFR MAF between patients with and without the TP53 mutation (P = 0.001). Levels of the tumor serum marker CA242 in patients with ctDNA-detectable mutations were higher than those in patients without ctDNA-detectable mutations. Conclusions: This study provides a better understanding of the spectra of genomic alterations detected by tissue and plasma ctDNA assays in Chinese patients with NSCLC. The present data also highlights the importance of tissue and plasma ctDNA screening by NGS to guide personalized therapy and promote the clinical management of NSCLC patients.
In this paper, the effects of different ignition positions and equivalence ratios on the explosion characteristics of syngas in a half-open Hele-Shaw duct were investigated. The ignition points are set at distances of 0 and 500 mm from the closed end. Moreover, the research range of equivalence ratio is 0.8-1.2. The experimental results indicate that different ignition positions and equivalence ratios influence the flame front structure and the dynamic characteristics of flame propagation. When the ignition position is at the closed end, the flame front undergoes several typical propagation stages before eventually reaching the open end of the duct. The time required by the flame to reach the open end decreases as the equivalence ratio increases. Meanwhile, when the ignition is in the middle of the duct, the flame simultaneously spreads to the open and closed ends. The time required to reach both sides decreases with the increase in the equivalence ratio. The flame front structure and pressure are primarily affected by the ignition position and the equivalence ratio. At the same ignition position, flame propagation velocity and maximum overpressure increase with the equivalence ratio. The pressure oscillation becomes more intense when the ignition position is close to the open end. At IP500, when the equivalence ratio is 0.8, multiple finger-shaped flame fronts emerge, accompanied by high-frequency flame oscillations. This study can provide guidance for the study of the flame propagation characteristics of syngas in millimeter-scale burners.
Objective: To evaluate the efficacy and toxicity of gefitinib and ecotinib in the treatment for patients with non-small cell lung cancer who have failed previous chemotherapy.Methods: A total of 28 patients were treated with ecotinib orally 125 mg(po,tid) or gefitinib 250 mg(po,qd).The efficacy and toxicity in the two groups were evaluated.Results: In ecotinib group,no complete regression(CR) was observed,partial response(PR) rate was 21.4%,stable disease(SD) 35.7%,progression of disease(PD) 28.6%;one patient was rejected due to paralysis and one patient died;response rate was 21.4% and the disease control rate was 57.1%.In gefitinib group,no CR was observed,PR was 7.1%,SD 50%,PD 14.3%;four patients died;response rate was 7.1% and the disease control rate was 57.1%.There was no significant difference between the two groups in response rate,disease control rate,progression-free survival and the overall survival(OS).The most common adverse effects were skin reactions in gefitinib group.There was no significant difference in adverse effects between the two treatment groups.Conclusion: The efficacy of ecotinib is similar comparable to that of gefitinib,and the adverse reactions were mild and well tolerated.Ecotinib is suitable and safe for patients with non-small cell lung cancer who have failed previous chemotherapy.
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