Sarwat Jahan

Khyber Medical University

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Sana Imran

Wichita State University

Khansa Khan

Northwest General Hospital and Research Center

Salman Zahir

Northwest General Hospital and Research Center

Manzoor Khan

Khyber Teaching Hospital

Mohammad Sair

Hôpital d'Instruction des Armées Sainte-Anne

Arfa Kamil

University of Khartoum

Shamim Akhtar

University of Faisalabad

Atta‐ur Rahman

University of Karachi

Maleeha Akram

Pir Mehr Ali Shah Arid Agriculture University

Naila Abrar

HITEC University

Cooperative Institutions

University of Karachi

Northwest General Hospital and Research Center

Khyber Medical University

Quaid-i-Azam University

International Center for Chemical and Biological Sciences

Khyber Medical College

Pir Mehr Ali Shah Arid Agriculture University

Federal Urdu University

Rawalpindi Medical University

Dow University of Health Sciences

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Synthesis and cytotoxic activity of some derivatives of alkyl piperidine.

PubMed (2013)

Sarwat Jahan Shamim Akhtar Zafar Saied Saify Nousheen Mushtaq Ali Akbar Sial

Synthesis of novel phenacyl derivatives of alkyl piperidine as cytotoxic agents via simple and single step reaction procedure is going to be reported here. Twelve new compounds were successfully synthesized in moderate yield and in solid form. Their synthesis was confirmed by TLC, melting point, CHN analysis and through different spectral studies such as UV, IR, Mass and proton NMR. The advantages of this synthetic route are simple operation, mild reaction conditions and good yields. These newly synthesized derivatives were extensively explored for their cytotoxicity by brine shrimp lethality assay.

Piperidine

Phenacyl

Proton NMR

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The Journey from Basic to Clinical Pharmacology

Journal of Islamabad Medical & Dental College (2024)

Sarwat Jahan Salman Zahir Manzoor Khan Khansa Khan Mashal Asad

Background The subjects of basic pharmacology and clinical pharmacology originate from same concepts but have a clear demarcation yet are so inter-linked and netted together that it is very critical and technical to identify and differentiate one from the other. This write-up is basically aimed to discuss and analyze the demarcations and similarities between basic and clinical pharmacology. Methodology Total 10 pharmacologists, pharmacists and medical specialists were recruited to conduct the survey from 1st December 2022 to 15th April 2023 in Northwest School of Medicine. Information was collected via literature search online, consulting Pharmacology books, libraries and discussions with subject experts. Results The basic pharmacology focuses on the study of the effects of substances on the body following experimental data that is collected via animal studies which defines the basic parameters and helps in derivation of the main foundational principles of the subject. Clinical pharmacology although follows the same basic principles and concepts but is the study of these principles in the human subjects rather than the animal studies. These studies are subjects however the two are inter-connected in many ways and the concepts go to and fro from one t the other. Conclusion The basic pharmacology is limited to the animal studies while the clinical pharmacology shelters human clinical trials and the policies, which come with the human studies and therapeutics.

Clinical Pharmacology

10.35787/jimdc.v13i1.1061

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Analgesic activity of alkyl piperidine derivatives.

PubMed (2016)

Sarwat Jahan Shamim Akhtar Arfa Kamil Nousheen Mushtaq Zafar Saied Saify

Piperidine is the most significant scaffold which reveals therapeutic potential because of its conformationally flexible nature. During the course of present investigations synthetic quaternary salts of alkyl piperidine with various phenacyl bromides were explored for their possible analgesic activity. Compounds I analogs (1a-1f) and compound II analogs (IIa-IIf) showed varying degree of analgesic activity when compared with pethidine as standard and its duration by tail immersion method.

Piperidine

Phenacyl

Pethidine

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Ameliorative Effect of Caryopteris grata benth. Against Arsenic-Induced Enzymatic Alterations in Testis of Albino Balb/c Mice

Polish Journal of Environmental Studies (2018)

Abdullah Khan Sarwat Jahan Fawad Aziz Mian Khan Khaliq Ur Rahman

Arsenic (As) contaminates drinking water worldwide and its potential impact on human health has been studied for decades.A number of traditional medicinal plants are used to counteract arsenic's deleterious effects on humans.Phytochemical screening of Caryopteris grata revealed the presence of Quercetin, myricetin, sesquiterpenoids, and spathulenol.The present study was designed to evaluate whether the crude extract of leaves of C. grata inhibited arsenic-induced testicular toxicity in albino BALB/c mice.To examine the effects, mice were divided into five groups (A-E) of 6 mice each: Group A was provided with distilled water and served as a control.Group B mice were given sodium arsenite (NaAsO 2 ) at a dose of 10 mg/kg body weight (bw) for 10 days orally.Groups C, D, and E were treated with NaAsO 2 plus graded doses of C. grata extract (150, 300, 400 mg/kg bw), respectively.Testicular activities of antioxidant enzymes such as CAT, POD, SOD, GSH, GSR, and serum testosterone levels were significantly (P<0.05)decreased in Group B compared to Group A. C. grata markedly normalized (P<0.05)levels of CAT (0.72 and 0.46 U/mint), POD (0.311 and 0.126 U/mint), SOD (2.11 and 1.33 U/mg protein), GSH (0.679 and 0.284 µmol/g), and GSR (216.11 and 172.25 nmol/min/mg protein), along with testosterone levels (1.18±0.017and 0.38±0.021ng/ml) at the tested doses, respectively.Conclusively, the crude extract of C. grata leaves may inhibit both arsenic's adverse effect on male reproductive hormones and testicular oxidative damage in mice.

BALB/c

Arsenic poisoning

10.15244/pjoes/84831

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Citations (4)

Are the discoveries directed to applications? Translating the status of translational research in Peshawar, Pakistan

Deleted Journal (2024)

Sarwat Jahan Salman Zahir Khansa Khan Abdul Moez Esam Khan

Background: Translational research plays a pivotal role in transforming basic scientific discoveries into practical applications, such as drugs and treatments, to address community health needs. This study aims to assess the awareness and perceptions of translational research among healthcare professionals in Peshawar, Pakistan. Methods: A cross-sectional descriptive design was employed, with data collected between January and July 2023 from public and private tertiary care hospitals in Peshawar, Pakistan. The study was approved by Ethical review board of Northwest School of Medicine via letter number: IRB & EC/2022-SM/074 dated: 15 Nov 2022. A sample size of 472 healthcare professionals was determined using the OpenEpi sample size calculator. The study utilized a self-structured questionnaire covering demographic information, awareness of translational research, and knowledge of its various aspects. Data analysis was performed using SPSS version 26, employing descriptive statistics and a one-sample t-test. Results: The study included 472 participants, with a mean age of 30.8 years, comprising various healthcare roles. Gender distribution showed 62.7% males and 37.3% females. Only 25% of respondents reported familiarity with translational research, while 75% indicated a lack of awareness. Information sources varied, with conferences/seminars (16.1%) and colleagues (5.5%) being prominent. Regarding the understanding of translational research, 64.2% admitted to having no idea. Identified barriers included lack of resources (14.8%), lack of awareness (7.6%), and lack of a sense of responsibility (1.3%). A significant majority (87.3%) reported poor knowledge of translational research, while only 12.7% indicated good knowledge. Conclusion: The findings highlight a substantial lack of awareness and understanding of translational research among healthcare professionals in Pakistan.

Translational Research

10.59736/ijp.22.03.903

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COMPARATIVE ANALYSIS OF HEPATOTOXIC POTENTIAL OF SIMVASTATIN WITH ROSUVASTATIN AND REVERSAL VIA MONTELUKAST & COENZYME Q10 IN BALB/C MICE

Pakistan Heart Journal (2022)

Manzoor Ahmed Khan Sarwat Jahan Amber Ashraf

Objectives: Statins cause elevations of AST and ALT, cholestatic hepatotoxicity, fulminant hepatitis, autoimmune hepatitis, and cirrhosis. (2) Various mechanisms are hypothesized including reduced levels of Coenzyme Q10, inflammation and oxidative stress. Coenzyme Q10 is anti-apoptotic and possess antioxidative potential whereas Montelukast can reduce the inflammation via inhibition of leukotrienepathway. Hence both these drugs may have a protective effect against statin induced hepatotoxicity. This study will include the comparison of hepatotoxic potential of simvastatin and rosuvastatin and assess the hepatoprotective efficacy of montelukast and coenzyme 10. Methodology: An experimental study of 2 weeks was conducted in the department of Pharmacology on a sample of 35 mice, randomly divided into 7 groups of 5 mice each for 2 weeks. Group 1 was used as control. Group 2 received simvastatin 50mg/kg/day of simvastatin intraperitoneally (I/P). Group 3 received I/P 50mg/kg/day rosuvastatin. Group 4 received 50mg/kg/day I/P simvastatin+3mg/kg of Montelukast. Group 5 received 50mg/kg/day of rosuvastatin +3mg/kg of Montelukast. Group 6 received 50mg/kg/day of simvastatin+10mg/kg of coenzyme Q10. Group 7 received 50mg/kg/day of rosuvastatin+10mg/kg of coenzyme Q10 I/P. Results: Both the statins showed hepatotoxicity, however Simvastatin showed higher liver function derangements. Montelukast did not reduce hepatotoxicity significantly. A slightly lower rise in liver parameters was however observed. Coenzyme Q10 did not show any protective potential against the statins, rather higher liver function derangements were observed. Conclusion: Simvastatin is more hepatotoxic as compared to Rosuvastatin. Motelukast does have a slight protective effect but is not significant enough. Coenzyme Q10 was not only not protective but infact indicated a hepatotoxic rend either by itself or via potentiating of statin induced hepatotoxicity.

Coenzyme Q10

Liver function

10.47144/phj.v55isupplement1.2437

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ISONIAZID INDUCED LIVER DAMAGE;

The Professional Medical Journal (2018)

Sarwat Jahan Sana Imran Naveed Ahsan

Objectives: To observe healthy effects of silymarin on liver histopathology againstliver damage, caused by isoniazid in rabbits. Study Design: Interventional study. Setting:Animal House of Jinnah Postgraduate Medical Centre, Karachi. Period: April to September2013. Methods: Total 28 rabbits of weight 1-1.5kg of either sex were used in this study. Whichwere divided randomly into four equal groups: Group I was control group. In group II silymarin(50mg/kg/day orally) was administered, in group III isoniazid (50mg/kg/dayorally) was given;and in group IV, effects of combination therapy of isoniazid and silymarin were observed. Beforestarting the drug therapy, at day 0 and one day after the end of study period i.e., at day 19, bodyweight of each animal was recorded. Rabbits were sacrificed on 19th day and the required liversample was taken for histopathological examination. The data feeding and analysis at the endof study was done on computer package SPSS (Statistical packages of social science) version16. Results: No mortality was recorded in any group. In group II (silymarin treated) animals inthis group exhibited no any histological changes in the hepatic lobule except few inflammatorycells 28.5% were seen in the portal tract. The liver microscopic examination in group III(Isoniazid treated), animals showed the disturbed architecture of the lobule. There were no fattychanges, whereas ballooning degeneration was 42.9%, hepatocytes necrosis was 71% andportal inflammation was 71.4% which was very severe. Animals in group IV, given combinationof silymarin and isoniazid showed the intact architecture of the hepatic lobule, in which 14.29%ballooning degeneration, whereas necrosis of hepatocytes and portal inflammation was mildin nature which may be due to hepatoprotective role of silymarin. Conclusion: Silymarin hashepatoprotective effects when given in combination with isoniazid.

Histopathology

Lobules of liver

10.29309/tpmj/18.4377

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Laryngeal Transection in a Patient after Hanging

Research and Practice in Anesthesiology - Open Journal (RPAOJ) (2017)

Hassan Ahmad Manjula Yadagiri Venkat Munikuntla Sarwat Jahan

Introduction:Hanging has become the second most common method of attempted suicide among adolescents and hanging injuries are associated with a high overall mortality rate. 1 Laryngeal injuries were observed in 35% to 45% of victims of hanging at autopsy. 2 Case presentation: We present a 40-year-old male patient presenting after hanging.On presentation, he was alert with glasgow coma scale (GCS) 15/15 and self-ventilating, but was aphonic with quadriplegia.He suffered from complete upper laryngeal transection.He was successfully intubated in accident & emergency department (A&E), but eventually had tracheostomy with subsequent laryngeal repair.He was immediately transferred to neuro rehabilitation centre.Conclusion: Airway injuries after hanging can be quite difficult to manage.][5]

10.17140/aoj-2-111

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A comparison of the level of appetite, food intake, metabolic hormones, basal metabolic rate and adiposity in normal and short stature children

Endocrine Abstracts (2020)

Nighat Kausar Maleeha Akram Gulbin Shahid Naseem Ahmed Mazhar Qayyum

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Basal (medicine)

10.1530/endoabs.70.aep270

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Citations (1)

Role of Neuromedin S in Plasma Testosterone and Cortisol Concentrations in Male Adult Rhesus Monkey (Macaca mulatta)

Pakistan Journal of Zoology (2011)

Sarwat Jahan Shakeel Ahmed N. Shah Hizbullah

Neuromedin S (NMS), a 36 amino acid peptide structurally related to neuromedin U, identified in rat brain as ligand for the G protein-coupled receptor FM4/TGR-1, also termed neuromedin U receptor type-2 (NMU2R). Its central expression is restricted to the suprachiasmatic nucleus, and involved in the regulation of dark light rhythms and suppression of food intake. Stimulatory role of NMS on hypothalamic pituitary gonadal axis (HPG) is reported in rodents. Yet the potential contribution of NMS in the control of reproductive axis in higher primates remains unexplored. In the present study, the effect of peripheral administration of NMS on testosterone and cortisol secretion in the adult male rhesus monkey was evaluated. Four adult male Rhesus monkeys were used for this study. Three different doses of NMS (20nmol, 40nmol and 60nmol) were injected through a teflon cannula implanted in saphenous vein. Blood samples were collected 45 min before and 120 min after NMS administration at 15 min intervals. The plasma concentration of testosterone and cortisol were determined by using specific assay systems. The NMS induced testosterone secretion was significantly (P 0.05) difference was observed at 20nmol. NMS has stimulatory role in testosterone secretion whereas its effect was inhibitory on cortisol secretion. In conclusion, the present study suggests the involvement of neuromedin S in the regulation of hypothalamic pituitary gonadal and adrenal axis in non human primates.

Hypothalamic–pituitary–gonadal axis

Adult male

Kisspeptin

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Citations (3)