Eric Johnson

Kaiser Permanente Washington Health Research Institute

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Carolyn M. Rutter

Fred Hutch Cancer Center

Aruna Kamineni

Kaiser Permanente Washington Health Research Institute

Jessica Chubak

Kaiser Permanente Washington Health Research Institute

Sebastien Haneuse

Harvard University

David Arterburn

Kaiser Permanente Washington Health Research Institute

Mary Kay Theis

Kaiser Permanente Washington Health Research Institute

Karen J. Coleman

Kaiser Permanente

Anita P. Courcoulas

University of Pittsburgh

Robert A. Li

Kaiser Permanente

Patrick Pfau

University of Wisconsin–Madison

Cooperative Institutions

Kaiser Permanente Washington Health Research Institute

Kaiser Permanente

University of Washington

Seattle University

University of Wisconsin–Madison

Group Health Cooperative

Harvard University

Henry Ford Health System

Colorado Permanente Medical Group

University of California, Los Angeles

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Pathway to Measuring Patient and Family Engagement: Prioritizing Engagement Behaviors in the Hospital Setting

Journal of patient-centered research and reviews (2016)

Emily A. Elstad Rikki Mangrum Pam Dardess Eric Johnson

Background/Aims: Growing evidence suggests that patient and family engagement (PFE) can help achieve the "Triple Aim" of improving population health and patient experiences of care while reducing costs. One critical gap as we work toward these goals is the lack of a clear approach to PFE measurement to assess associated outcomes and gauge health care performance. In this project, we draw on an existing framework to define behaviors that constitute PFE in the hospital setting and identify a subset of these behaviors that are of high priority for measure development and implementation.

10.17294/2330-0698.1381

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Citations (0)

Mo1566 Screening Colonoscopy and Risk of Incident Late-Stage Colorectal Cancer Diagnosis in Average-Risk Adults: a Nested Case-Control Study

Gastrointestinal Endoscopy (2013)

Chyke A. Doubeni Sheila Weinmann Kenneth Adams Aruna Kamineni Diana S. M. Buist

Sigmoidoscopy

Nested case-control study

10.1016/j.gie.2013.03.314

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Citations (2)

Strictures, Rings, Webs (Peptic, Caustic, Radiation, Anastomotic)

Springer eBooks (2012)

Eric Johnson Eric A. Gaumnitz Mark Reichelderfer

Caustic (mathematics)

Peptic

10.1007/978-1-4614-3794-9_42

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Citations (2)

Visual evaluation of the larynx and hypopharynx during esophagogastroduodenoscopy: a safety and feasibility study

Surgical Endoscopy (2014)

Shanlee M. Stevens Eric Johnson Patrick Pfau Seth H. Dailey

Esophagogastroduodenoscopy

10.1007/s00464-014-3796-z

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Citations (8)

Facile and rapid DNA extraction and purification from food matrices using IFAST (immiscible filtration assisted by surface tension)

The Analyst (2012)

Lindsay N. Strotman Guangyun Lin Scott M. Berry Eric Johnson David J. Beebe

Extraction and purification of DNA is a prerequisite to detection and analytical techniques. While DNA sample preparation methods have improved over the last few decades, current methods are still time consuming and labor intensive. Here we demonstrate a technology termed IFAST (Immiscible Filtration Assisted by Surface Tension), that relies on immiscible phase filtration to reduce the time and effort required to purify DNA. IFAST replaces the multiple wash and centrifugation steps required by traditional DNA sample preparation methods with a single step. To operate, DNA from lysed cells is bound to paramagnetic particles (PMPs) and drawn through an immiscible fluid phase barrier (i.e. oil) by an external handheld magnet. Purified DNA is then eluted from the PMPs. Here, detection of Clostridium botulinum type A (BoNT/A) in food matrices (milk, orange juice), a bioterrorism concern, was used as a model system to establish IFAST's utility in detection assays. Data validated that the DNA purified by IFAST was functional as a qPCR template to amplify the bont/A gene. The sensitivity limit of IFAST was comparable to the commercially available Invitrogen ChargeSwitch® method. Notably, pathogen detection via IFAST required only 8.5 μL of sample and was accomplished in five-fold less time. The simplicity, rapidity and portability of IFAST offer significant advantages when compared to existing DNA sample preparation methods.

Sample Preparation

Filtration (mathematics)

10.1039/c2an35506j

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Citations (34)

Regulation of Cellulase Formation in Clostridium thermocellum

Microbiology (1985)

Eric Johnson F. BOUCHOT A.L. Demain

Summary: True cellulase activity (i.e. degradation of crystalline cellulose) was markedly derepressed when cellobiose-grown cells were transferred to fructose or sorbitol, especially while the cells were adapting over many hours to these carbon sources. On the other hand, the long lag phase on glucose was not accompanied by derepression. Transfer to cellobiose resulted in low cellulase production. Growth on crystalline cellulose derepressed cellulase production. Addition of cellobiose (the preferred carbon source for growth) to cells adapting to fructose caused a rapid burst of growth and cessation of cellulase synthesis. After cells had adapted to growth on fructose or sorbitol, repression set in and, after a number of transfers, growth on these carbon sources yielded cellulase at a level even lower than with cellobiose or glucose. It appears that rapid growth on a soluble sugar such as cellobiose causes carbon source repression which is relieved during slow growth on crystalline cellulose or during the growth lag on fructose or sorbitol. The reason for the lack of cellulase derepression during the growth lag on glucose is unexplained.

Derepression

10.1099/00221287-131-9-2303

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Citations (77)

Accounting for misclassification in electronic health records-derived exposures using generalized linear finite mixture models

Health Services and Outcomes Research Methodology (2016)

Rebecca A. Hubbard Eric Johnson Jessica Chubak Karen J. Wernli Aruna Kamineni

Proxy (statistics)

Imputation (statistics)

10.1007/s10742-016-0149-5

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Citations (14)

Cohort restriction based on prior enrollment: Examining potential biases in estimating cancer and mortality risk

Observational Studies (2016)

Susan M. Shortreed Eric Johnson Carolyn M. Rutter Aruna Kamineni Karen J. Wernli

Electronic health records and administrative databases provide rich, longitudinal data for health-related research.These data cover large, diverse populations creating excellent research opportunities, but have limitations.In particular, information is available only for individuals who are enrolled in a particular health system; thus, studies often exclude individual's with short enrollment history.Such cohort restriction may cause selection bias in absolute risk estimates for the full enrollee population.We use hazard ratios (HRs) to estimate the association between length of prior enrollment and cancer and all-cause mortality risk.HRs different from one indicate restricted cohorts would produce biased risk estimates for the full enrollee population.Our study sample included 170,708 enrollees of a Western Washington healthcare delivery system.Unadjusted models found individuals with 10 or more years of prior enrollment had higher risk of cancer and death compared to those with less than 5 years prior enrollment (HRs ranged from 1.29 -3.01).Age-and sexadjusted models accounted for much of this difference (HRs: 0.93-1.24).Models adjusting for additional covariates had similar results (HRs: 0.91 -1.14).After evaluating potential selection bias, we conclude that, in this setting, age-and sex-standardizing risk estimates can remove most of the bias due to lengthy, prior-enrollment cohort restrictions.Before generalizing estimates based on a selected sample of patients meeting prior enrollment criteria, researchers should assess the potential for selection bias.

Absolute risk reduction

Information bias

10.1353/obs.2016.0002

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Citations (5)

Conjugative Transfer of theEscherichia coli–Clostridium perfringensShuttle Vector pJIR1457 toClostridium botulinumType A Strains

Plasmid (1998)

Marite Bradshaw Michael C. Goodnough Eric Johnson

Shuttle vector

Clostridium botulinum

Gene cluster

Strain (injury)

10.1006/plas.1998.1366

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Citations (17)

Surging interest in leakproof pumps

Chemical engineering (1989)

G. Parkinson Eric Johnson

Presentation d'un ensemble de pompes etanches repondant aux consignes de securite et de protection de l'environnement lors de la manutention de liquides dangereux

Source

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Citations (4)