Hongmei Dai

Third Xiangya Hospital

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Xiafei Hong

Peking Union Medical College Hospital

Wenming Wu

Peking Union Medical College Hospital

Yupei Zhao

Peking Union Medical College Hospital

Xianze Wang

Shanghai Academy of Agricultural Sciences

Yuanying Deng

Third Xiangya Hospital

Lingling Zhao

Zhejiang Chinese Medical University

Masayuki Itoh

National Center of Neurology and Psychiatry

Yu‐ichi Goto

National Center for Global Health and Medicine

Jing Tian

Dalian Polytechnic University

Mingyi Zhao

Central South University

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Central South University

Peking Union Medical College Hospital

Third Xiangya Hospital

Chinese Academy of Sciences

National Center of Neurology and Psychiatry

Shanghai Jiao Tong University

Sichuan University

Peking University

Zhejiang University

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Chlorpyrifos-induced dysregulation of synaptic plasticity in rat hippocampal neurons

Journal of Environmental Science and Health Part B (2023)

Wenjuan Zhou Chen Zhang Peipei Wang Yuanying Deng Hongmei Dai

Chlorpyrifos (CPF) is a widely used organophosphorus pesticide. Increasing evidence has shown that exposure to CPF in early life might induce neurodevelopmental disorders, but the pathogenesis remains uncertain. Synaptic plasticity plays a crucial role in neurodevelopment. This study aimed to investigate the effect of CPF on synaptic plasticity in hippocampal neurons and establish the cellular mechanism underlying these effects. Using CPF-exposed rat and primary hippocampal neurons model, we analyzed the impact of CPF on the synaptic morphology, the expression level of a presynaptic protein, a postsynaptic protein and ionotropic glutamate receptors (iGluRs), as well as the effects on the Wnt/β-catenin pathway. We found that the synapses were shortened, the spines were decreased, and the expression of synaptophysin (Syp), postsynaptic density-95 (PSD-95), GluN1, GluA1 and Wnt7a, as well as active β-catenin in primary hippocampal neurons was decreased. Our study suggests that CPF exposure induced dysregulation of synaptic plasticity in rat hippocampal neurons, which might provide novel information regarding the mechanism of CPF-induced neurodevelopmental disorders.

Synaptophysin

Postsynaptic density

Nonsynaptic plasticity

10.1080/03601234.2023.2171236

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Citations (4)

5-HT1A Receptor Agonist Treatment Partially Ameliorates Rett Syndrome Phenotypes in mecp2-Null Mice by Rescuing Impairment of Neuron Transmission and the CREB/BDNF Signaling Pathway

International Journal of Molecular Sciences (2022)

Hongmei Dai Yoshikazu Kitami Yu‐ichi Goto Masayuki Itoh

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the gene that encodes methyl CpG-binding protein 2 (MECP2) and is characterized by the loss of acquired motor and language skills, stereotypic movements, respiratory abnormalities and autistic features. There has been no effective treatment for this disorder until now. In this study, we used a Mecp2-null (KO) mouse model of RTT to investigate whether repeated intraperitoneal treatment with the 5-HT1A receptor agonist tandospirone could improve the RTT phenotype. The results showed that administration of tandospirone significantly extended the lifespan of Mecp2-KO mice and obviously ameliorated RTT phenotypes, including general condition, hindlimb clasping, gait, tremor and breathing in Mecp2-KO mice. Tandospirone treatment significantly improved the impairment in GABAergic, glutaminergic, dopaminergic and serotoninergic neurotransmission in the brainstem of Mecp2-KO mice. Decreased dopaminergic neurotransmission in the cerebellum of Mecp2-KO mice was also significantly increased by tandospirone treatment. Moreover, RNA-sequencing analysis found that tandospirone modulates the RTT phenotype, partially through the CREB1/BDNF signaling pathway in Mecp2-KO mice. These findings provide a new option for clinical treatment.

MeCP2

Rett Syndrome

10.3390/ijms232214025

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Citations (2)

RimJ is responsible for N α-acetylation of thymosin α1 in Escherichia coli

Applied Microbiology and Biotechnology (2009)

Hongqing Fang Xu Zhang Lin Shen Xinxi Si Yuantao Ren

10.1007/s00253-009-1994-8

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Citations (24)

[The effect of para-aortic lymph node metastasis on the resectability of pancreatic cancer].

PubMed (2019)

Hongmei Dai Xiafei Hong Haiyu Pang Wenming Wu Yupei Zhao

Pancreatic cancer has poor prognosis and lymph node metastasis is a poor prognostic factor in patients with resectable pancreatic cancer. The metastatic prevalence of para-aortic lymph node (PALN) ranges from 9.1% to 26.5% and it is listed as the distant metastatic group in pancreatic cancer. Nevertheless, it is controversial whether PALN metastasis is the contraindication of surgery in resectable pancreatic cancer for the shortage of level Ⅰ evidence.This study concluded that PALN metastasis indicated poor prognosis in patients with pancreatic cancer, but some patients with PALN metastases could benefit from surgery and their survival could be much improved after the combination of surgery and adjuvant therapy. Therefore, it is not wise to refuse surgery for all pancreatic cancer patients with PALN metastasis and the clinicians can cautiously choose the patients to do surgery. Besides, there are mainly retrospective studies rather than prospective and multicenter studies to explore the prognosis of pancreatic cancer patients with PALN metastasis. Thus, more prospective and multicenter studies are needed to decide whether PALN metastasis is an independent prognostic factor in patients with resectable pancreatic cancer.淋巴结转移是胰腺癌患者预后差的一个重要因素，主动脉旁淋巴结在可切除胰腺癌中的转移率为9.1%~26.5%，其在胰腺癌中被列为远处转移。但主动脉旁淋巴结转移是否为可切除胰腺癌的绝对手术禁忌尚缺乏Ⅰ级证据支持。目前已发表的文献显示，主动脉旁淋巴结转移患者总体预后差，但部分患者可从手术中获益，手术治疗联合辅助治疗可明显延长患者生存期。因此，可切除胰腺癌发生主动脉旁淋巴结转移时，临床医师可谨慎地为部分患者选择手术治疗。此外，目前研究胰腺癌主动脉旁淋巴结转移预后的文献主要为回顾性研究，尚需要更多前瞻性多中心研究为临床治疗决策提供强有力的证据。.

Contraindication

10.3760/cma.j.issn.0529-5815.2019.01.014

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The Influence of Self-Control and Social Status on Self-Deception

Frontiers in Psychology (2018)

Mengmeng Ren Bowei Zhong Wei Fan Hongmei Dai Bo Yang

The purpose of this study was to explore the effects of self-control and social status on self-deception. The present study adopted a forward-looking paradigm to investigate how self-control and social status influence self-deception. In Experiment 1, participants were asked to complete 10 questions, after they predicted and completed 40 questions (commonsense judgment materials) either with or without answer hints. The results indicated that the participants had higher predicted scores under conditions with answer hints compared with conditions without answer hints and that the predicted scores were much higher than the actual scores under conditions with answer hints. In Experiment 2, individuals with different self-control traits were chosen to perform the operation and induction of the perception of social status and then complete tests such as Experiment 1. The results showed that differences in the predicted scores between conditions with answer hints and those without answer hints were observed to be greater in individuals with low self-control traits than in individuals with higher self-control traits, however, such differences between individuals with higher and low self-control traits were only observed in conditions with low social status perception, not in the conditions with high social status perception. The findings indicated that compared with individuals with high self-control, low self-control individuals tended to produce more self-deception. In addition, high social status in the individuals' perception could restrain the influence of low self-control on self-deception, while low social status in the individuals' perception could increase the self-control's influence on self-deception.

Self-deception

Perceived control

10.3389/fpsyg.2018.01256

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Citations (18)

Use of indocyanine green staining technique for phacoemulsification in white cataract

DOAJ (DOAJ: Directory of Open Access Journals) (2014)

Hongmei Dai Lan Li Yunchuan Li Yuanping Zhang Xu Zha

Indocyanine Green

10.3980/j.issn.1672-5123.2014.08.16

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Pancreatic neuroendocrine tumor cancer stem cells: potential novel therapeutic targets?

Translational Cancer Research (2016)

Hongmei Dai Xiafei Hong Xianze Wang Lin Chen Wenming Wu

New therapeutic treatments are urgently needed for patients with pancreatic neuroendocrine tumors (PanNETs) that are insensitive or resistant to current therapeutic methods. The cancer stem cells (CSCs) in PanNETs may imply a promising and novel therapeutic approach to treat patients with advanced stage tumor and improve patient survival through targeting various molecular pathways. In this review, we define the process of identifying CSCs in PanNETs and address the potential therapeutic implications of targeting CSCs. The CSCs in PanNETs are marked by aldehyde dehydrogenases (ALDH) or CD90. We discuss the relevant molecular pathways in ALDH+ and CD90+ CSCs, including the Src, Notch, Hedgehog, Wnt/β-catenin, mammalian target of rapamycin (mTOR), epidermal growth factor receptor (EGFR) and signal transducers and activators of transcription 3 (STAT3) signaling pathways. The function of Src signaling has been identified in a NET cell line, which suggests it could become a new therapeutic target in PanNETs. With the exception of the STAT3 signaling pathway, signaling pathways involved in the tumorigenicity of CSCs in many other cancers play a role in the pathophysiology of PanNETs. These molecular pathways may be potential targets for the treatment of PanNETs despite a lack of studies relating them to PanNET CSCs and more studies are needed to clarify the role of these signaling pathways in PanNETs. Additionally, targeting of the cellular surface markers CD47 and CD73 decreased the tumor growth of ALDH+ CSCs in PanNETs cell lines. In conclusion, the study of PanNET CSCs could aid in the development of novel therapeutic targets for PanNETs, and this review details the molecular pathways that might become new targets.

10.21037/11270

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The effect of HMGB1 on sub-toxic chlorpyrifos exposure-induced neuroinflammation in amygdala of neonatal rats

Toxicology (2015)

Jing Tian Hongmei Dai Yuanying Deng Jie Zhang Ying Li

Chlorpyrifos (CPF), one of organophosphorus pesticides (OPs), is associated with developmental neurotoxicity. Inflammatory response is closely related with CPF-induced neurotoxicity. The present study aimed at exploring whether sub-toxic CPF exposure on neonatal rats results in neuroinflammation that mediated by HMGB1/TLR4/NF-κB signaling pathway in the amygdala. The neonatal rats were subcutaneously injected with 5mg/kg CPF for 4 consecutive days (postnatal day 11-14) with or without HMGB1 inhibitor, glycyrrhizin. We assessed the levels of pro-inflammatory cytokines at 12, 24, and 72 h after CPF exposure. The role of HMGB1 on neuroinflammation in sub-toxic exposure during brain development was studied. CPF-treated neonatal rats exhibited a significant increase in the expression of pro-inflammatory cytokines, such as IL-6, TNF-α and HMGB1, and a significant increase in the activation of NF-κB in the amygdala after CPF exposure. Inhibited HMGB1 reduced the release of IL-6 and TNF-α, and inhibited activation of NF-κB. Our findings indicate that CPF exposure on developmental brain might induce the activation of neuroinflammation mediated by HMGB1/TLR4/NF-κB pathway in the amygdala.

Neurotoxicity

HMGB1

10.1016/j.tox.2015.10.010

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Citations (45)

Two Siblings Showing a Mild Phenotype of Joubert Syndrome with a Specific CEP290 Variant

Neuropediatrics (2022)

Daisuke Uda H. Kondo Koichi Tanda Zenro Kizaki Masashi Nishida

Joubert syndrome (JS) is a genetic neurodevelopmental disorder characterized by lower brainstem dysplasia and cerebellar vermis agenesis termed molar tooth sign (MTS), psychomotor retardation, abnormal respiratory pattern in infancy, and oculomotor abnormalities. Arima syndrome (AS), which is a severe form of JS, is characterized by severe psychomotor retardation, congenital visual impairment, progressive renal dysfunction, and lower brainstem dysplasia from early infancy. Numerous patients with AS expire in early childhood. Recently, c.6012-12T> A in the CEP290 gene was reported as a specific variant of AS. Herein, we report the cases of two siblings showing a phenotype of JS with compound heterozygous mutations (c.6012-12T > A / c.5924delT) in the CEP290 gene. The older sister (aged 19 years) had hypotonia, hypertelorism, and anteverted nares since birth. As a neonate, she developed a transient abnormal respiratory pattern and nystagmus, and brain magnetic resonance imaging (MRI) showed MTS. The younger sister (aged 13 years) exhibited mild hypotonia and pendular nystagmus as a neonate; MRI revealed MTS. Both sisters had psychomotor retardation, oculomotor dysfunction, and bilateral renal cysts with normal renal function. They can walk and have simple conversation. They do not meet the diagnostic criteria for AS, and their symptoms were milder than those of previously reported cases with this specific mutation. This report indicates the expanding spectrum of the CEP290 variant.

Joubert syndrome

Psychomotor retardation

Cerebellar vermis

Proband

10.1055/a-1865-6890

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Citations (2)

The prognostic impact of primary tumor resection in pancreatic neuroendocrine tumors with synchronous multifocal liver metastases

Pancreatology (2018)

Lin Chen Hongmei Dai Xiafei Hong Haiyu Pang Xianze Wang

Primary tumor

Univariate analysis

Pancreatic tumor

Liver tumor

10.1016/j.pan.2018.04.014

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Citations (18)