Fiona Cowie

Beatson West of Scotland Cancer Centre

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Co-Authors

Jeff White

Royal Adelaide Hospital

Ioanna Nixon

University of Kentucky HealthCare

Jairam Sastry

Royal Hospital for Children

CR Pinkerton

Texas Children's Hospital

Steven Lo

University of Glasgow

Milind Ronghe

Royal Hospital for Children

Sindu Vivekanandan

South Eastern University of Sri Lanka

Barry Pizer

Alder Hey Children's Hospital

D.J. Saunders

The Christie NHS Foundation Trust

Kate Wheeler

Oregon Health & Science University

Cooperative Institutions

University of Glasgow

Royal Hospital for Children

Beatson West of Scotland Cancer Centre

University College London

University of Edinburgh

The University of Texas MD Anderson Cancer Center

Queen Elizabeth University Hospital

Texas Children's Hospital

Institute of Cancer Research

Royal Marsden Hospital

Author Statistics

Papers

Citation

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Research Field

Primary Hodgkin's disease of bone

Clinical Oncology (1991)

Fiona Cowie A. Benghiat C S Holgate

Eosinophilic granuloma

Primary bone

Bone disease

10.1016/s0936-6555(05)81210-5

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Citations (2)

Primary Hodgkin's disease of bone

Clinical Oncology (1991)

Fiona Cowie A. Benghiat C S Holgate

Eosinophilic granuloma

Primary bone

Bone disease

10.1016/s0936-6555(05)80748-4

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Citations (11)

Unusual case of hyponatraemia

BMJ Case Reports (2012)

Ryan Karlus Hannaway Fiona Cowie Edward B. Jude

Hyponatraemia is the most common electrolyte abnormality, encountered in up to 30% of inpatients. Inappropriate management can have serious implications for patients; including demyelinating disease, coma and death. We have used a case report to identify the common problems, and provide useful strategies in management for which these can be avoided. The aim was to provide a framework which clinicians can adopt, in order to improve clinical practice and provide optimum outcome for the patient.

Abnormality

Coma (optics)

Demyelinating Disorder

10.1136/bcr-03-2012-6143

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Citations (1)

P67 Possible modulation of concurrent parkinson’s disease in the management of metastatic gist: a review of two cases

Journal of Neurology Neurosurgery & Psychiatry (2019)

Taylor Watson-Fargie Donald G. Grosset Jonathan White Fiona Cowie

Modulation (music)

10.1136/jnnp-2019-abn.129

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Citations (0)

Re-implantation of cryopreserved ovarian cortex resulting in restoration of ovarian function, natural conception and successful pregnancy after haematopoietic stem cell transplantation for Wilms tumour

Journal of Assisted Reproduction and Genetics (2016)

Cheryl E. Dunlop Brian M. Brady Marie Mclaughlin Evelyn E. Telfer Jeff White

With the improvement of long-term cancer survival rates, growing numbers of female survivors are suffering from treatment-related premature ovarian insufficiency (POI). Although pre-treatment embryo and oocyte storage are effective fertility preservation strategies, they are not possible for pre-pubertal girls or women who cannot delay treatment. In these cases, the only available treatment option is ovarian cortex cryopreservation and subsequent re-implantation. A 32-year-old woman had ovarian cortex cryopreserved 10 years previously before commencing high-dose chemotherapy and undergoing a haematopoietic stem cell transplant for recurrent adult Wilms tumour, which resulted in POI. She underwent laparoscopic orthotopic transplantation of cryopreserved ovarian cortex to the original site of biopsy on the left ovary. She ovulated at 15 and 29 weeks post-re-implantation with AMH detectable, then rising, from 21 weeks, and conceived naturally following the second ovulation. The pregnancy was uncomplicated and a healthy male infant was born by elective Caesarean section at 36+4 weeks gestation. This is the first report of ovarian cortex re-implantation in the UK. Despite the patient receiving low-risk chemotherapy prior to cryopreservation and the prolonged tissue storage duration, the re-implantation resulted in rapid restoration of ovarian function and natural conception with successful pregnancy.

Ovarian Cortex

Ovarian Tissue Cryopreservation

Premature ovarian failure

10.1007/s10815-016-0805-2

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Citations (35)

Us, Them and It: Modules, Genes, Environments and Evolution

Mind & Language (2008)

Fiona Cowie

Abstract: The Architecture of Mind is an ambitious and informative work, surveying an impressive range of empirical literature and arguing that the mind is massively modular. However, it suffers from two major theoretical flaws. First, Carruthers’ concept of a module is weak, so much so that it robs his thesis of massive modularity of any real substance. Second, his conception of how the mind’s modules evolved ignores the role of niche construction and cultural evolution to its detriment.

Modularity

Niche construction

10.1111/j.1468-0017.2008.00342.x

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Citations (36)

Spontaneous Resolution of Radiotherapy-induced Craniopharyngioma Cyst

Cureus (2015)

Mario Teo Fiona Cowie Paul Fivey Jerome St George

Craniopharyngioma cyst enlargement after surgery and radiation therapy is often presumed to represent a treatment failure, instigating further management strategies. We present an eight-year-old girl with a small intrasellar residuum post-resection who then developed cystic enlargement post-radiotherapy. With close surveillance, the cyst spontaneously resolved.

Craniopharyngioma

10.7759/cureus.272

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Citations (0)

Possible Modulation of Concurrent Parkinson'S Disease in the Management of Metastatic Gist: A Review of Two Cases

The Journal of the Royal College of Physicians of Edinburgh (2018)

Taylor Watson-Fargie Donald G. Grosset Jeff White Fiona Cowie

Imatinib, a tyrosine kinase inhibitor, is the mainstay of treatment for resected high-risk (adjuvant and metastatic) gastrointestinal stromal tumour (GIST) - a rare form of sarcoma. There has been recent research into the neuroprotective role and modulation of dopaminergic neurones by imatinib through the abl pathway in Parkinson's disease (PD). We describe two patients from a single cancer centre with concurrent diagnoses of PD and metastatic GIST receiving imatinib and standard PD management. The cases highlight a potential reduction in PD progression using Unified Parkinson's Disease Rating Scale. Further research into repurposing of imatinib for PD may provide additional management options for this neurodegenerative illness.

Repurposing

Imatinib Mesylate

10.4997/jrcpe.2018.309

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Citations (2)

Treatment of rare cancers: gastrointestinal stromal tumours

British Journal of Hospital Medicine (2006)

Fiona Cowie

Gastrointestinal stromal tumour, the most common mesenchymal malignancy of the gastrointestinal tract, is a rare cancer that until recent years had severely limited therapeutic options. This article looks at its epidemiology, aetiology, pathophysiology, diagnosis, current treatment and potential new treatment options on the horizon.

Etiology

Gastrointestinal cancer

Pathophysiology

10.12968/hmed.2006.67.7.21620

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Citations (2)

Lung involvement in neuroblastoma: Incidence and characteristics

Medical and Pediatric Oncology (1997)

Fiona Cowie Robin Webb Corbett C. Ross Pinkerton

The presence of lung metastases in neuroblastoma often leads to doubt about the diagnosis due to rarity of disease at this site. To determine more precisely the incidence and nature of pulmonary disease in neuroblastoma the data base of the European Neuroblastoma Study Group (ENSG) was examined. Information was obtained about 35/746 stage IV patients (and 1 patient who was registered as having stage II disease) documented to have pulmonary disease at presentation. Of these 5 were registered with pleural effusions, 18 pleural infiltrations, and 13 intrapulmonary lesions. Review of these cases, however, suggested that only 9 patients (1.2%; 95% exact confidence interval 0.42–1.99%, binomial distribution) had disease consistent with secondary neuroblastoma in lung or pleura. There was no correlation with clinical features, age, sex, or other disease sites, and outcome was uniformly poor. Med. Pediatr. Oncol. 28:429–432, 1997. © 1997 Wiley-Liss, Inc.

10.1002/(sici)1096-911x(199706)28:6<429::aid-mpo7>3.3.co;2-x

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Citations (4)