Sialolipoma of the salivary gland is a tumor with ambiguous histogenesis. Histologically, this lesion is composed of mature adipose tissue and salivary glandular components. To the best of our knowledge, only 12 documented cases of sialolipoma have been reported in the literature. Except for 1 congenital case, all of the cases were found in adult patients. In this report, we present a unique case of sialolipoma with diffuse sebaceous differentiation in a 3-year-old female child. The differential diagnoses are discussed.
There are few reported cases of endobronchial metastasis of pheochromocytoma in pathology literature. We present here a 56-year old woman who underwent left lower lobectomy of lung, following pneumonia with unresolved chest radiographs. Computed tomography showed a lobulated soft tissue mass, measuring, 38×27 mm, at the perivascular space of anterior mediastinum. The resected specimen, showed lobulated tumor arranged in nesting pattern within arcuate vascular network. Immunohistochemistry showed intense positive staining of epitheloid cell (chief cells) for chromogranin and synaptophysin which were negative for cytokeratin. Sustentacular cells were strongly positive for S-100. Although very rare, physicians should keep in mind the possibility of endobronchial metastasis in patients with a history of pheochromocytoma.
Primary giant-cell tumor of the salivary gland is a rare lesion with an incompletely characterized histogenesis. To the best of our knowledge, only 16 cases have been previously documented in the English-language literature. We report a new case, which occurred in a 75-year-old man who presented with a parotid mass and cervical lymphadenopathy. The patient underwent a left total parotidectomy and cervical lymph node dissection. As far as we know, ours is the only reported case of a primary giant-cell tumor of the salivary gland in which the patient presented with lymph node metastasis. Because so little is known about giant-cell tumor of the salivary gland, we use the occasion of this case report to describe the cytologic, histologic, and immunohistochemical characteristics that we observed.
Objective: To investigate whether evaluations of antenatal umbilical coiling index (aUCI) could predict postnatal umbilical coiling index (UCI) (pUCI) in people with gestational diabetes mellitus (GDM) compared with normal pregnancy independent of maternal demographic and reproductive characteristics.Method: In this prospective study, 105 women with normal pregnancy, and 117 women with pregnancy complicated by GDM were recruited. Ultrasound scan of umbilical cord was performed at 18–23 and 37–41 weeks of gestation (WG). Evaluation of pUCI, as the reference standard, was performed within 24 hours after delivery.Findings: There was no significant relationship between aUCI and maternal demographic and reproductive characteristics. The mean for pUCI was 0.21 ± 0.12 in the GDM group, and 0.21 ± 0.09 in the normal pregnancy (p = .61). In the GDM group, a significant association was found between aUCI and pUCI categories (p = .004). The area under curve (AUC) was less than 0.5 for hypocoiling in both groups. For hypercoiling it was 0.84 ± 0.04 in the GDM group and 0.75 ± 0.06 in the normal pregnancy group (18–23 WG). In the GDM group the cutoff points that predict hypercoiling were 0.28 (18–23WG), and 0.21 (37–41WG). These were 0.35 (18–23WG), and 0.33 (37–41WG) in the normal pregnancy group. Diagnostic accuracy analysis revealed that in the GDM group, the sensitivity and specificity of hypercoiling for prediction of pUCI were 0.94 and 0.70 respectively at 18–23 WG.Conclusions: Antenatal hypercoiling at the second trimester of pregnancy strongly predict postnatal hypercoiling in pregnancies complicated by GDM.
Background : Animal models have been proven useful in elucidating the details of interaction between pathogenic bacteria and their human hosts, in addition to assessing the efficacy of therapeutic compounds and vaccines. In this study, we investigate the colonization of Helicobacter pylori ( H. pylori ) in experimentally-infected guinea pigs over a six-month period. Materials and Methods: A bacterial suspension was prepared by mixing four H. pylori isolates obtained from patients diagnosed with gastric ulcer. Within a one week period, five female guinea pigs were dosed orally with bacterial suspension for a total of three times. One control animal was gavaged with normal saline. Stool samples were collected at two-week intervals for six months. We used PCR, the stool antigen test, and indirect immunofluorescence assay (IFA) to assess samples for the presence of H. pylori . Stomachs obtained from two chloroform-killed animals, at 8 and 24 weeks, were investigated for histopathologic changes. Results: H. pylori 16S rDNA was amplified from the stool samples of five guinea pigs. The stool antigen test was also positive in all five animals. IFA demonstrated the presence of H. pylori antigens in the stools from all five animals. PCR, stool antigen test and IFA results showed no H. pylori in the stool of the control animal. We observed infiltration of mature lymphocytes and plasma cells in the stomachs of animals killed at 8 and 24 weeks. Conclusion: The occurrence of H. pylori 16S rDNA and antigens in stool samples of guinea pigs demonstrated persistent colonization of H. pylori in the stomachs of guinea pigs. Histopathological findings have confirmed mild-severe gastritis induced by the bacterial infection. The stomach of a guinea pig is similar to the human stomach, in that it is sterile, lined by glandular epithelium, lacks a vitamin C synthesizing system and produces the cytokine interleukin-8. Accordingly, the guinea pig can be considered an appropriate animal model for long-term experiments to follow the process of H. pylori pathogenesis or to assess the efficacy of antibiotics or vaccines.
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