Yanqin Huang

Shandong University of Traditional Chinese Medicine

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Keng Yuan

Jiangxi Provincial Academy of Medical Sciences

Yinying Hu

Shanghai Normal University

Yi Zhang

Central South University

Jie-kai Yu

Second Affiliated Hospital of Zhejiang University

Demin Lu

Second Affiliated Hospital of Zhejiang University

Xiaomei Zhu

Children's Hospital of Fudan University

Ping Ao

University of Adelaide

Zijian Xu

China Agricultural University

Zhigang Wang

First Affiliated Hospital of Xi'an Jiaotong University

Leroy Hood

University of Washington

Cooperative Institutions

Nanchang University

North China Electric Power University

Shandong University of Traditional Chinese Medicine

Zhejiang University

Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Huazhong University of Science and Technology

Shanghai Jiao Tong University

Jiangxi Provincial Academy of Medical Sciences

Chinese Academy of Sciences

Second Affiliated Hospital of Zhejiang University

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Green Recycling of Valuable Metals in Retired Lithium Battery: Reduction and Dissociation of Cathode Under the Effect of Biomass Components

Yangyue Wei Zijian Xu Yiwei Zhang Mingjin Wang Yutong Liu

Lithium metal

10.2139/ssrn.4954460

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Gene silencing of indoleamine 2,3-dioxygenase hinders tumor growth through angiogenesis inhibition

International Journal of Oncology (2017)

Jinfeng Pan Keng Yuan Shanshan Peng Yanqin Huang Yujuan Zhang

The significance of indoleamine 2,3-dioxygenase-1 (IDO1) has been studied in various types of tumors, but the relationship between IDO1 and tumor angiogenesis needs further delineation. We aimed to clarify the relationship between tumor angiogenesis and IDO1 expression, and to explore the possibility of IDO1-targeting molecular therapy for lung cancer. For the first time, we found that silencing the IDO1 gene using small interfering RNA (siRNA) inhibits in vitro cancer cell invasion and migration. We further demonstrated that knockdown of IDO1 decreased the formation of vasculogenic mimicry. In addition to these in vitro findings, we also demonstrated that in vivo IDO1 gene silencing using short hairpin RNA (shRNA) delayed tumor onset and inhibited tumor growth in the mouse model. Immunostaining showed that IDO1 gene silencing inhibited tumor angiogenesis. Moreover, the expression of IDO1 was associated with microvessel density (MVD) labeled by CD34 and CD146. These findings indicate that IDO1 has the potential to participate in or contribute to the formation of new capillaries, supporting the applicability of IDO1-targeting molecular therapy in lung cancer.

Indoleamine 2,3-dioxygenase

10.3892/ijo.2017.3975

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Supporting file 1 from Beyond cancer genes: colorectal cancer as robust intrinsic states formed by molecular interactions

Figshare (2017)

Ruoshi Yuan Suzhan Zhang Jie-kai Yu Yanqin Huang Demin Lu

Details and references for figure 4.

10.6084/m9.figshare.5532127

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Dissociation Mechanism on Spent Ternary Lithium-Ion Battery Cathode Via Carbothermal Reduction Reaction with Cellulose and Lignin

Yangyue Wei Zijian Xu Yiwei Zhang Mingjin Wang Yutong Liu

Carbothermic reaction

10.2139/ssrn.5054577

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A study of increasing CD4 lymphocytes stimulated by ginsenoside Rg3 and the killing effect on gastric cancer cell MKN-45

Experimental and Laboratory Medicine (2011)

Yanqin Huang

Objective To investigate the immune stimulation of ginsenoside Rg3 on the lymphocytes and its effect on gastric cancer cell MKN-45.Methods Normal lymphocytes separated by density gradient were stimulated by ginsenoside Rg3,then CD4 lymphocyte expressions were detected by flow cytometry;The inhibition of MKN-45 with ginsenoside Rg3 was determined by MTT method;The apoptosis of MKN-45 induced by ginsenoside Rg3 was observed after HE staining.Results The expression level of CD4 lymphocytes stimulated by ginsenoside Rg3 was significantly higher than that of the normal controls(P0.05);The inhibition or the apoptosis rate of MKN-45 induced by ginsenoside Rg3 was significantly different compared with the controls(P0.05).Conclusion Ginsenoside Rg3 can stimulate increasing CD4 lymphocytes and inhibit the growth of gastric cancer cell MKN-45.

MTT assay

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[Effect of hydroxycamptothecin (HCPT) on proliferation and apoptosis of rat hepatic stellate cells].

Yi Zhang Qun Deng Guoxin Hu Keng Yuan Yuan Fang

To investigate the effects of hydroxycamptothecin (HCPT) on proliferation and apoptosis of rat hepatic stellate cells (HSC).Rat HSC line (HSC-T6) and rat hepatocyte line (BRL-3A) were treated with different concentrations of HCPT (0, 0.008, 0.016, 0.031, 0.125, 0.25, 0.5, 1, 2, 4, 8, 16, 32 mg/L respectively) for 24 h. Cell proliferation was assessed by MTT colorimetric assay, apoptosis was detected with PI staging followed by flow cytometry, and by DNA ladder assay. The morphological change of apoptosis was observed under transmission electron microscopy (TEM).MTT assay indicated that HCPT significantly inhibited the proliferation of HSC-T6 and BRL-3A in a dose-dependent manner. 24 h after the treatment with different concentrations of HCPT (0.25, 0.5, 1 mg/L), the apoptosis rate (13.46%+/-2.42%, 26.25%+/-5.65%, 47.05%+/-8.76%, respectively) in HSC-T6 was significantly higher than that in control cells (4.89%+/-1.80%, F = 34.24, P less than 0.01). 24 h after 0.5 mg/L HCPT treatment, cell shrinkage, nucleoli disappearance, chromatin condensation were found under TEM, and DNA ladder was demonstrated by agarose gel electrophoresis.HCPT could significantly inhibit proliferation and induce apoptosis of HSC-T6 in a dose-dependent manner.

Hepatic stellate cell

MTT assay

Agarose gel electrophoresis

10.3760/cma.j.issn.1007-3418.2010.03.012

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miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer

Scientific Reports (2016)

Zhigang Wang Lu Xu Yinying Hu Yanqin Huang Yujuan Zhang

Abstract Macrophage polarization is a highly plastic physiological process that responds to a variety of environmental factors by changing macrophage phenotype and function. Tumor-associated macrophages (TAMs) are generally recognized as promoting tumor progression. As universal regulators, microRNAs (miRNAs) are functionally involved in numerous critical cellular processes including macrophage polarization. Let-7b, a miRNA, has differential expression patterns in inflamed tissues compared with healthy controls. However, whether and how miRNA let-7b regulates macrophage phenotype and function is unclear. In this report, we find that up-regulation of let-7b is characteristic of prostatic TAMs and down-regulation of let-7b in TAMs leads to changes in expression profiles of inflammatory cytokines, such as IL-12, IL-23, IL-10 and TNF-α. As a result, TAMs treated with let-7b inhibitors reduce angiogenesis and prostate carcinoma (PCa) cell mobility. Let-7b may play a vital role in regulating macrophage polarization, thus modulating the prognosis of prostate cancer.

Macrophage polarization

M2 Macrophage

Polarization

10.1038/srep25602

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Citations (86)

Site selection of sludge pyrolysis projects based on improved interactive multi-indicators decision-making method under vague linguistic environment: A decision framework from the perspective of low-carbon

Energy (2024)

Yanqin Huang Yuhang Zhen Lanling Liu Yiwei Zhang Xiaoyang Ning

10.1016/j.energy.2024.133662

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