Wolf‐Dieter Heiss

Max Planck Institute for Metabolism Research

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Karl Herholz

University of Manchester

101

K. Wienhard

Max Planck Institute for Metabolism Research

Rudolf Graf

Max Planck Institute for Metabolism Research

G. Pawlik

Klinikum Darmstadt

Jan Sobesky

Charité - Universitätsmedizin Berlin

Martin Grond

University of Siegen

B. Szelies

University of Cologne

Jobst Rudolf

Papageorgiou General Hospital

Alexander Thiel

Jewish General Hospital

M. Neveling

University of Cologne

Cooperative Institutions

Inserm

148

University of Cologne

141

Max Planck Institute for Metabolism Research

140

Heidelberg University

114

Center for Translational Molecular Medicine

112

Academy of Emergency Medicine and Care

110

Max Planck Society

104

Klinik und Poliklinik für Neurologie

Charité - Universitätsmedizin Berlin

Neurology, Inc

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Prolonged Transient Ischemia Results in Impaired CBF Recovery and Secondary Glutamate Accumulation in Cats

Journal of Cerebral Blood Flow & Metabolism (1996)

Junji Taguchi Rudolf Graf Gerd Rosner Wolf‐Dieter Heiss

Effects of prolonged focal ischemia [middle cerebral artery occlusion (MCAO)] of 1, 2, and 4 h followed by 15-h reperfusion on CBF, extracellular amino acids, purine catabolites, evoked potentials, and infarction were studied in core (A:auditory cortex) and border zone (SF: somatosensory cortex) areas of halothane-anesthetized cats. Following MCAO, CBF reduction was severe in A (<15 ml 100 g-1 min-1) and mild to moderate in SF. Prominent elevation of glutamate and abolition of evoked potentials in A contrasted with milder and more variable disturbances in SF. After reperfusion, recovery of CBF, glutamate, and evoked potentials was fast and persistent in the 1- and 2-h groups. In the 4-h group, immediate recovery of CBF, glutamate, and evoked potentials was incomplete, and secondary deterioration of all parameters was obtained at the end of the experiments. Infarction in the 4-h group was significantly larger than in the 1- and 2-h groups. Persistent recovery of extracellular glutamate concentration and electrical function and salvage of neuronal tissue from infarction therefore seem to depend on successful restoration of CBF, which in turn depends on the magnitude and the duration of CBF reduction and of exposure to potentially harmful substances such as glutamate during the ischemic attack.

Transient (computer programming)

10.1097/00004647-199603000-00012

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Citations (25)

Evaluation of 75Br-labelled butyrophenone neuroleptics for imaging cerebral dopaminergic receptor areas using positron emission tomography

European Journal of Nuclear Medicine (1986)

Stephen M. Moerlein Peter Laufer Gerhard St�cklin G. Pawlik K. Wienhard

Radioligand

Raclopride

Lipophilicity

Butyrophenone

Binding potential

10.1007/bf00256924

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Citations (26)

Neuroradiology

Cambridge University Press eBooks (2019)

Michael Brainin Wolf‐Dieter Heiss

10.1017/9781108659574.004

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Citations (0)

Best Measure of Ischemic Penumbra: Positron Emission Tomography

Stroke (2003)

Wolf‐Dieter Heiss

Penumbra

10.1161/01.str.0000092396.70827.28

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Citations (35)

Primär- und Sekundärprävention des Schlaganfalls

Andreas H. Jacobs Jan Sobesky Christian Dohmen M. Neveling Wolf‐Dieter Heiss

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Intravenous Actilyse (R) in the three-hour time window following ischaemic stroke

International Journal of Clinical Practice (2003)

Wolf‐Dieter Heiss Susanne Richter-Schmuelling

Ischaemic stroke

Stroke

Source

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Comparison between hydrogen clearance and microsphere technique for rCBF measurement.

Stroke (1981)

Wolf‐Dieter Heiss Heiko Traupe

Regional cerebral blood flow was measured repeatedly in anesthetized and immobilized cats under various experimental conditions by recording the clearance of inhaled hydrogen with inserted platinum electrodes and by recording the distribution of 15 mu microspheres labeled with 3 different radioisotopes. The values for both methods in normal cortical tissue were comparable (75.7 +/- 23.5 ml/100 g min for H2-clearance; 67.6 +/- 26.2 ml/100 g min for microsphere technique), but were below those recorded in awake cats. With both methods the values could be reliably reproduced (correlation coefficient between measurements: 0.903 for H2-clearance, 0.754 for microsphere technique). During ischemia induced by temporary occlusion of the middle cerebral artery the microsphere technique usually yielded higher flow values than the H2-clearance, and did not indicate severe ischemia in 6 out of 20 instances. After restoration of flow, hyperperfusion was observed by the microsphere technique in 2 cases only while H2-clearance indicated hyperemia in 6 instances. This limited comparability between the 2 methods was also expressed in a low correlation coefficient (0.486) calculated from 139 flow values obtained simultaneously with both methods. The discrepancy between the methods under pathological conditions might be due mainly to the different recording volumes: while Pt-electrodes record H2-clearance from a few mm3 or less, tissue samples of 300-700 mg were necessary for the microsphere technique and inhomogeneities of flow may thereby escape detection. The technique for measuring cerebral blood flow in an experimental setup should be selected according to the requirements of the study and according to the limitations of the various methods.

10.1161/01.str.12.2.161

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Citations (54)

Darstellung pathologischer zerebraler Prozesse mit gestörter Blut-Hirn-Schranke

Springer eBooks (1985)

Wolf‐Dieter Heiss Curt Beil Karl Herholz G. Pawlik Rainer Wagner

10.1007/978-3-642-82566-8_4

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The sensitivity of 18‐fluorodopa positron emission tomography and magnetic resonance imaging in Parkinson's disease

European Journal of Neurology (2003)

Wolf‐Dieter Heiss R. Hilker

Parkinson's disease (PD) as the most important movement disorder is characterized by a progressive loss of nigral dopamine neurons and a subsequent degeneration within several other transmitter systems. Functional brain imaging with positron emission tomography (PET) and the radiotracer 18‐fluorodopa (FDOPA) is capable to quantify the deficiency of dopamine synthesis and storage within pre‐synaptic striatal nerve terminals. Therefore, FDOPA‐PET allows the diagnosis of PD in early disease stages and the differentiation of clinically unclear cases from other movement disorders, e.g. essential tremor. Additionally, FDOPA‐PET imaging permits the follow‐up of disease progression, the assessment of medical and surgical PD therapy strategies with possible neuroprotective properties and the detection of pre‐clinical disease in subjects at risk for the disorder. The classical domain of morphological magnetic resonance imaging (MRI) is the differentiation of symptomatic Parkinsonism from PD. However, recent advances in MRI data acquisition and analysis techniques demonstrated MRI to be also a valuable tool for detection of nigral pathology in PD and for differentiation of neurodegenerative disorders with atypical Parkinsonism.

10.1046/j.1351-5101.2003.00709.x

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Citations (57)

Multidomain Lifestyle Interventions for the Prevention of Cognitive Decline After Ischemic Stroke

Stroke (2015)

Karl Matz Yvonne Teuschl Bernadette Firlinger Alexandra Dachenhausen Magdalena Keindl

Background and Purpose— Cognitive impairment occurs in ≤30% of all stroke survivors. However, effective therapies aimed at preventing poststroke cognitive decline are lacking. We assessed the efficacy of a multidomain intervention on preventing cognitive decline after stroke. Methods— In this randomized, observer-blind trial patients were recruited within 3 months after an acute stroke in 5 Austrian neurological centers. Patients were assigned to a 24-month lifestyle-based multidomain intervention or standard stroke care. Primary outcomes were the cognitive subscale of the Alzheimer Disease Assessment Scale (ADAS-cog) and occurrence of cognitive decline in the composite scores of at least 2 of 5 cognitive domains at 24 months. Results— A total of 101 patients were randomized into multi-intervention and 101 into standard care during June 2010 and November 2012. Of them, 76 patients in the intervention group and 83 in the control group were included in the final intention-to-treat analysis. At 24 months, 8 of 76 (10.5%) patients in the intervention group and 10 of 83 (12.0%) patients in the control group showed cognitive decline corresponding to a relative risk reduction of 0.874 (95% confidence interval, 0.364–2.098). The change in ADAS-cog from baseline to 24 months was not different either (median 0 [IQR, −1 to 2] in both groups; P =0.808). Conclusions— This trial found no benefit of 24-month multidomain intervention with focus on improvement in lifestyle and vascular risk factors on the incidence of poststroke cognitive decline in comparison with standard stroke care. Studies with a larger sample size are needed. Clinical Trial Registration— URL: http://clinicaltrials.gov . Unique identifier: NCT01109836.

Stroke

Cognitive Decline

10.1161/strokeaha.115.009992

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Citations (57)