Ankit Lodhi

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Prabhash Nath Tripathi

Institute of Engineering

Anurag Chaudhary

Zoological Survey of India

Shweta Dumoga

Indian Institute of Technology Delhi

Nilay Nandi

Sachin Chaudhary

University of Sharjah

Pooja Yadav

Central University of Punjab

Mohd Talib

Institute of Engineering

Nazia Siddiqui

Dayalbagh Educational Institute

Amit Tiwari

Ashoka University

Abdel‐Nasser El‐Shorbagi

University of Sharjah

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Institute of Medical Sciences

Institute of Engineering

Banaras Hindu University

Shobhit University

University of Arkansas for Medical Sciences

Himalayan Institute of Yoga Science and Philosophy

University of Sharjah

Indian Institute of Technology Indore

Indian Institute of Chemical Biology

Charles R. Drew University of Medicine and Science

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Nanofertilizers

CRC Press eBooks (2023)

Prabhash Nath Tripathi Ankit Lodhi Mohd Talib Anurag Chaudhary Nazia Siddiqui

Fertilizers have been a part of agriculture for many centuries to aid farmers. However, conventional fertilizers are costly and hazardous to people and the world. As a result, ecologically friendly fertilizers with greater nutritional values and adaptability to soil and environment are required to support human beings. Nutrient regulation is constantly the main consideration to optimize agriculture yield. The effective utilization of nutrients is critical to producing nutritious crops, a significant worldwide issue due to its dependence on agrochemicals. An innovative fertilizer strategy is needed to strengthen agronomic system production, while environmentally beneficial fertilizers are required more than synthetic fertilizers. Nanotechnology is becoming an attractive potential substitute for nanofertilizers to improve the quality of fertilizers. Nanofertilizers comprise nanoformulations of nutrient content supplied to crops, allowing for persistent and uniform absorption. Earlier studies indicate that nanofertilizers boost crop productivity by intensifying nutrient utilization, minimizing soil poisoning, reducing the potential negative effects of excessive synthetic fertilizers, and increasing their application rate. Furthermore, applying nanofertilizers reduces waste, economizing, preserving, and protecting the ecosystem. Therefore, nanofertilizers and beneficial microorganisms (nanobiofertilizers) have established a key application in sustainable farming. However, even though nanofertilizers have many benefits, their impacts before and after usage should always be closely reviewed and considered to maximize their benefits. This chapter will summarize the most significant innovations in the nanomaterials' formulation used as nanofertilizers to study their categories, mechanisms of the appliance, and future effects on plants. In addition, scientific investigations should focus on the ecological risks of nanofertilizers. Also, it should emphasize green production, biosynthesized nanofertilizers, and their safety, biodistribution, and threats to ensure their use in sustainable farming conditions.

10.1201/9781003364429-4

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Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants

Degenerative Neurological and Neuromuscular Disease (2024)

Prabhash Nath Tripathi Ankit Lodhi Sachchida Nand Nilay Nandi Shweta Dumoga

Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. While there is currently no cure for AD, several pharmacotherapeutic targets and management strategies have been explored. Additionally, traditional medicinal plants have gained attention for their potential role in AD management. Pharmacotherapeutic targets in AD include amyloid-beta (Aβ) aggregation, tau protein hyperphosphorylation, neuroinflammation, oxidative stress, and cholinergic dysfunction. Traditional medicinal plants, such as Ginkgo biloba, Huperzia serrata, Curcuma longa (turmeric), and Panax ginseng, have demonstrated the ability to modulate these targets through their bioactive compounds. Ginkgo biloba , for instance, contains flavonoids and terpenoids that exhibit neuroprotective effects by reducing Aβ deposition and enhancing cerebral blood flow. Huperzia serrata , a natural source of huperzine A, has acetylcholinesterase-inhibiting properties, thus improving cholinergic function. Curcuma longa , enriched with curcumin, exhibits anti-inflammatory and antioxidant effects, potentially mitigating neuroinflammation and oxidative stress. Panax ginseng's ginsenosides have shown neuroprotective and anti-amyloidogenic properties. The investigation of traditional medicinal plants as a complementary approach to AD management offers several advantages, including a lower risk of adverse effects and potential multi-target interactions. Furthermore, the cultural knowledge and utilization of these plants provide a rich source of information for the development of new therapies. However, further research is necessary to elucidate the precise mechanisms of action, standardize preparations, and assess the safety and efficacy of these natural remedies. Integrating traditional medicinal-plant-based therapies with modern pharmacotherapies may hold the key to a more comprehensive and effective approach to AD treatment. This review aims to explore the pharmacotherapeutic targets in AD and assess the potential of traditional medicinal plants in its management. Keywords: Alzheimer's disease, acetylcholinesterase, amyloid beta, tau protein, traditional medicine, Ayurvedic herbs, acetylcholinesterase inhibitors, neurodegenerative disorders, cognition

10.2147/dnnd.s452009

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