Yuliya Alyokhina

Lomonosov Moscow State University

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А. Л. Калинкин

Moscow State University

Daria Krjukova

Lomonosov Moscow State University

M. I. Afanasov

Lomonosov Moscow State University

E. M. Seredenina

Lomonosov Moscow State University

Denis V. Pozdyshev

Lomonosov Moscow State University

Alexander A. Yaroslavov

Lomonosov Moscow State University

N. S. Perov

Lomonosov Moscow State University

Vladimir I. Muronetz

Lomonosov Moscow State University

A.V. Knotko

Lomonosov Moscow State University

Zukhra Zoirova

Lomonosov Moscow State University

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Lomonosov Moscow State University

Moscow State University

Federal Medical-Biological Agency

Clinical Hospital No. 8

Medical Technologies (Czechia)

Federal State Budgetary Institution "Federal Center For Cardiovascular Surgery" Ministry of Health of The Russian Federation

Federal Almazov North-West Medical Research Centre

City Clinical Hospital

Eötvös József Főiskola

Institute of Experimental Cardiology

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Prospects for the treatment of central sleep apnea and Cheyne-Stokes respiration in heart failure

South Russian Journal of Therapeutic Practice (2021)

Yuliya Alyokhina E. M. Seredenina А. Л. Калинкин

The risk factors, clinical manifestations, pathophysiology, diagnosis and treatment options for central sleep apnea and Cheyne-Stokes respiration in patients with heart failure are highlighted in this review. The effectiveness and prospects of therapeutic approaches are discussed: CPAP therapy, adaptive servo ventilation, transvenous stimulation of the phrenic nerve.

Cheyne–Stokes respiration

Central sleep apnea

Pathophysiology

10.21886/2712-8156-2021-2-1-8-16

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Magnetically Controlled Hyaluronic Acid–Maghemite Nanocomposites with Embedded Doxorubicin

Polymers (2023)

V. V. Spiridonov Zukhra Zoirova Yuliya Alyokhina N. S. Perov M. I. Afanasov

The controllable delivery of drugs is a key task of pharmacology. For this purpose, a series of polymer composites was synthesized via the cross-linking of hyaluronate and a hyaluronate/polyacrylate mixture with Fe2O3 nanoparticles. The cross-linking imparts magnetic properties to the composites, which are more pronounced for the ternary hyaluronate/polyacrylate/γ-Fe2O3 composites compared with the binary hyaluronate/Fe2O3 composites. When dispersed in water, the composites produce microsized hydrogel particles. Circulation of the ternary microgels in an aqueous solution at a speed of 1.84 cm/s can be stopped using a permanent external magnet with a magnetic flux density of 400 T. The composite hydrogels can absorb the antitumor antibiotic doxorubicin (Dox); the resulting constructs show their cytotoxicity to tumor cells to be comparable to the cytotoxicity of Dox itself. The addition of the hyaluronidase enzyme induces degradation of the binary and ternary microgels down to smaller particles. This study presents prospectives for the preparation of magnetically controlled biodegradable polymer carriers for the encapsulation of bioactive substances.

Polyacrylic acid

10.3390/polym15173644

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