Left ventricular non-compaction, often known as LVNC, is a form of congenital cardiomyopathy that is extremely uncommon. It is a condition that may be identified by an elevated number of endomyocardial trabeculations as well as an increase in their prominence. Alcoholic cardiomyopathy, also known as ACM, is a non-ischemic form of dilated cardiomyopathy that is characterized by contractile failure and an enlargement of the heart ventricles. It is not entirely known whether or not there is a clinically significant overlap in phenotypic characteristics between the two illnesses. We report a patient who had previously been diagnosed with ACM and who had cardiac MRI (CMR) results that fit the criteria for both LVNC and ACM.
A BSTRACT Context: Hypertension is a growing concern worldwide, particularly in developing countries. In India, it significantly contributes to morbidity and mortality. Various states have reported an increasing incidence of hypertension, underscoring the need to assess its prevalence and associated risk factors. Aims: This study aimed to evaluate the prevalence of hypertension in Punjab, compare urban and rural areas, and identify the associated risk factors. Settings and Design: A community-based cross-sectional study was conducted across Ludhiana, Punjab, involving three urban areas and three villages. Methods and Materials: Residents aged 20 years and older were selected, and their blood pressure was measured according to JNC-7 guidelines. Other demographic details and personal histories, including alcohol consumption and hypercholesterolemia, were documented for each participant. Results: The prevalence of hypertension in Ludhiana was 62%, with an equal distribution between rural and urban areas. However, fewer individuals in rural areas were aware of their hypertensive status, and the number of new cases was higher in these areas. Hypertension was notably more prevalent among males and those with lower educational backgrounds. Identified risk factors included obesity, a sedentary lifestyle, high socioeconomic status (SES), salt intake, stress levels, alcohol consumption, hypercholesterolemia, and low literacy rates, which were more prevalent in rural areas compared to urban areas. Conclusions: Our study highlights the increasing incidence of hypertension in Punjab, emphasizing that rural populations are more likely to be unaware of their condition. This finding suggests a limited reach of adequate healthcare services in these areas.
Background Advances in cancer treatment have markedly improved survival rates but have also heightened morbidity due to treatment-related side effects. Despite this, the literature remains scarce on predicting the incidence of acute cardiac toxicity resulting from chemotherapy. We conducted a prospective evaluation to assess the incidence, timing, clinical correlates, global longitudinal strain (GLS), and response to heart failure (HF) therapy in patients experiencing cardiotoxicity. Aims and objectives Our study aimed to assess the cardiovascular complications of cancer therapy in breast cancer patients, with particular emphasis on therapy-related cardiac dysfunction. Materials and methods We conducted a prospective observational study to detect chemotherapy-related cardiac dysfunction (CTRCD) in breast cancer patients attending the outpatient department (OPD) or admitted to Dayanand Medical College and Hospital (DMCH), Ludhiana, Punjab, between March 1, 2020, and October 31, 2021. We assessed left ventricular ejection fraction (LVEF) at baseline, mid-chemotherapy, and post-chemotherapy. Patients who developed left ventricular dysfunction (LVD) had their chemotherapy regimen modified and were initiated on HF therapy. Results Ninety-seven patients (mean age: 50.74±10.30 years) were enrolled and categorized into the LVD group (n=13) and non-LVD group (n=84). CTRCD developed in 13 patients (13.4%). Patients with estrogen receptor (ER) positive, progesterone receptor (PR) positive, and human epidermal growth factor receptor 2 (HER2) positive status, as well as those in cancer stages III and IV, are at higher risk of developing LV dysfunction. Among the 13 patients, 10 (77%) experienced complete recovery, while three (23%) had partial recovery. Markers for partial recovery included cancer stages III-IV, younger age, lower body mass index (BMI), lower radiotherapy dosage, lower mean chemotherapy dosage, and left breast involvement. Conclusion Our findings suggest that acute cardiotoxicity is not linked to the cumulative dose of anthracyclines. Early detection, modification of chemotherapy regimens, and prompt initiation of CTRCD therapy can lead to substantial recovery of cardiac dysfunction.
Left ventricular non-compaction cardiomyopathy, often known as LVNC, is a form of congenital cardiomyopathy that is extremely uncommon. It is a condition that may be identified by an elevated number of endomyocardial trabeculations as well as an increase in their prominence. Alcoholic cardiomyopathy, also known as ACM, is a non-ischemic form of dilated cardiomyopathy that is characterized by contractile failure and an enlargement of the heart ventricles. It is not entirely known whether or not there is a clinically significant overlap in phenotypic characteristics between the two illnesses. We report a patient who had previously been diagnosed with ACM and who had cardiac MRI results that fit the criteria for both LVNC and ACM.
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