Robert Eya’ama Mve

University of Health Sciences

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Joseph Privat Ondo

Université des Sciences et Techniques de Masuku

Bourdettes Meye

Université des Sciences et Techniques de Masuku

Louis Clément Obame Engonga

Dieudonné Nkoghe

Université des Sciences de la Santé

Amel Kevin Alame-Emane

Cédric Sima Obiang

Université des Sciences et Techniques de Masuku

Hilaire Moundounga Kenguele

Université des Sciences et Techniques de Masuku

Hilaire Moudounga Kenguele

Ludjer Mpiga Ekambou

Louis Clément Obame Engonga

Université des Sciences et Techniques de Masuku

Cooperative Institutions

Université des Sciences et Techniques de Masuku

Centre International de Recherches Médicales de Franceville

Centre de Recherche Médicales de Lambaréné

Université des Sciences de la Santé

Libreville Hospital

University of Liège

Institut de Recherche Pour le Développement

Centre Hospitalier Universitaire de Liège

Omar Bongo University

Université de Rouen Normandie

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Pharmacological Effects of the "Hydroxychloroquine-Azithromycin Combination" on the Hematological and Biochemical Parameters of Symptomatic COVID-19 Patients: Case of Amissa Bongo Regional Hospital Center of Franceville

Zenodo (CERN European Organization for Nuclear Research) (2023)

Bourdettes Meye Dieudonné Nkoghe Robert Eya’ama Mve Joseph Privat Ondo Cédric Sima Obiang

Hydroxychloroquine

Center (category theory)

10.5281/zenodo.8265061

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Malaria prevalence in children aged 0 -5 years in the commune of Ntoum , northwest Gabon

Research Square (Research Square) (2024)

Bourdettes Meye Hilaire Moudounga Kenguele Robert Eya’ama Mve Ludjer Mpiga Ekambou Joseph Privat Ondo

Abstract Background In Gabon, the malaria burden among children five residing in the western corner of the Estuary province is unknown. Methods This prospective observational study was conducted over six (6) months, from June to December 2024, at NTOUM Regional (NR) Hospital. Blood samples were collected from 274 children attending the hospital, and analyzed using two different diagnostic methods (microscopy and rapid diagnostic test (RDT)). The socio-demographic data of the children's parents or guardians and the means of malaria prevention used in their household were recorded using a structured questionnaire. Data were then analyzed using R software version 4.1.2. Statistical significance was set at P < 0.05. Results 189 blood samples were microscopically and immunochromatographically positive, representing a overall malaria prevalence of 69%. Very good agreement was observed between light microscopy and RDT (97.5%). Among all the independent variables considered in this study, only the unemployment was significantly associated with malaria (OR = 2.28; 95% CI = 1.2–4.35; P = 0.0118). Whereas, children vomiting were less likely to be infected with malaria (OR = 0.53; 95% CI = 0.29–0.99; P = 0.045) The parents or guardians of the children surveyed were mostly educated to secondary or university level (94.4%) and preferred insecticide - treated nets to aerosol insecticides (71% and 21.2% respectively). Conclusion Malaria is a major public health problem in Gabon. It affects particularly children under five year’s old living in the commune of Ntoum. To break the chain of malaria transmission in this part of the country, better access to malaria preventive measures is needed.

10.21203/rs.3.rs-5667238/v1

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Malaria prevention practices among patients attending the NTOUM departmental hospital, Northwest Gabon

Open Access Research Journal of Biology and Pharmacy (2024)

Bourdettes Meye Amel Kevin Alame-Emane Hilaire Moundounga Kenguele Robert Eya’ama Mve Joseph Privat Ondo

Introduction: In Gabon, a territory located in Central Africa, prevention is an essential measure in the fight against malaria. The aim of this study was to evaluate, in the Komo-Mondah department, the prophylaxis practices employed by the inhabitants of the commune of Ntoum and the prevalence of anti-malarial drugs prescribed by local doctors. Methods: We carried out a prospective, cross-sectional study over a 3-month period, on patients of both sexes and of all ages who came for consultation to the departmental hospital of Ntoum. Patients who had a prescription for malaria drugs at the end of their medical visit were included in the study. Results: Of the 248 subjects enrolled, children under 5 years of age were the main victims (84%).Indeed, children under 5 were two (2) and three (3) times more likely to test positive to malaria than the age group 16-24 (OR = 2.44 [1.05 - 5.63]; P ˂ 0.05) , 25 and over (OR= 3.10 [1.46 - 6.59]; P ˂ 0.05), respectively. Anti-malaria prophylaxis was practiced by 80% of the study population. Patients who declared sleeping under a bed net appear to be protected compare to those who did not (OR= 0.53 [0.28 - 0.97] ; P ˂ 0.05). Self-medication was recorded in 29% of patients, and the drugs most commonly prescribed by doctors were artemisinin-based combinations, including Artefan (51%), Coartem (30%) and Eurartesim (2%). Conclusion: Although conventional prophylaxis measures (vector control and chemoprevention) are adopted by many Gabonese, careful pharmacological management and the implementation of targeted, long-term prevention-surveillance and health education strategies will enable effective malaria control in this part of Gabon.

10.53022/oarjbp.2024.11.1.0019

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