Miruna Bratiloveanu

Carol Davila University of Medicine and Pharmacy

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Mihai Dumitru

Carol Davila University of Medicine and Pharmacy

Daniela Vrînceanu

Carol Davila University of Medicine and Pharmacy

CȘ

Crenguța Șerboiu

Emergency University

Adrian Costache

Carol Davila University of Medicine and Pharmacy

Maria Dana Gheorghiev

Oana Maria Pătraşcu

Carol Davila University of Medicine and Pharmacy

Anca-Ionela Cîrstea

Carol Davila University of Medicine and Pharmacy

Andreea Nicoleta Marinescu

Carol Davila University of Medicine and Pharmacy

Mariana Costache

Carol Davila University of Medicine and Pharmacy

Andreea Marinescu

Emergency University

Cooperative Institutions

Carol Davila University of Medicine and Pharmacy

Clinical Emergency Hospital Bucharest

Emergency University

Amita Health St. Mary's Hospital

Grigore T. Popa University of Medicine and Pharmacy

Bucharest Emergency University Hospital

University of Bucharest

University of Medicine and Pharmacy of Craiova

Ovidius University

Institutul Cantacuzino

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Parotid Gland Tumors: Molecular Diagnostic Approaches

International Journal of Molecular Sciences (2024)

Daniela Vrînceanu Mihai Dumitru Miruna Bratiloveanu Andreea Marinescu Crenguța Șerboiu

Parotid gland pathology represents a web of differential diagnoses. There are many complex cases that require extensive diagnostic tests for a complete and correct final pathology diagnosis. Currently the official classification of parotid gland tumors extends over more than 40 subtypes. We performed a query of the PubMed database regarding the use of molecular biology tests in performing a better characterization of the tumors in specific cases. By using fluorescence in situ hybridization (FISH), reverse transcription polymerase chain reaction (RT-PCR) or next-generation sequencing, the team managing complex cases can offer a personalized therapeutic solution. We review the molecular differential diagnosis according to published articles in the last 5 years for many types of parotid gland tumors ranging from benign to borderline malign tumors to malign aggressive tumors. Mucoepidermoid carcinoma is a distinct subtype of parotid malignancy that was the subject of a consistent number of articles. However, the molecular biology diagnosis techniques helped more in excluding the diagnosis of mucoepidermoid carcinoma, and probably retrospectively limiting the number of cases with this final diagnosis. In Romania, the molecular biology diagnosis is available only in limited research facilities and should receive more consistent funding that will make it available on a larger scale. The novelty of this scoping review is that we propose an algorithm for molecular differential diagnosis of the tumors that could be encountered in the parotid gland.

10.3390/ijms25137350

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Challenges in the Management of Giant Carcinoma Ex-Pleiomorphic Adenoma of the Parotid Gland in a Single Tertiary Center

Medicina (2024)

Miruna Bratiloveanu Mihai Dumitru Andreea Nicoleta Marinescu Crenguța Șerboiu Oana Maria Pătraşcu

Background and Objectives: Carcinoma ex-pleiomorphic adenoma (CXPA) is a carcinoma derived from a primary or recurrent pleiomorphic adenoma. Microscopically, non-invasive CXPA (intracapsular and carcinoma in situ), minimally invasive CXPA (extracapsular invasion less than 1.5 mm), and invasive CXPA (extracapsular invasion more than 1.5 mm) are described. Materials and Methods: We performed a retrospective clinical study over the period of 2009–2023 in patients admitted to the ENT Department of the Bucharest University Emergency Hospital. Results: In the studied group, there was a net male predominance of 2.5:1. The tumor evolution until presentation was 6.64 years on average, with values between 2 and 20 years. The reasons for presenting to our department included a sudden increase in size in eleven cases (78.57%), pain in nine cases (64.29%), peripheral facial paralysis in eight cases (57.14%), skin invasion/ulceration in five cases (35.71%), and massive tumor hemorrhage in one case (7.14%). There were histopathological results on paraffin of myoepithelial CXPA in four cases (28.57%), of high-grade CXPA (salivary duct, secretory) in eight cases (57.14%), and of squamous CXPA in two cases (14.29%). The patients with unfavorable evolution showed the following characteristics: a tumor diameter over 11 cm (four cases), integument invasion (four cases), perivascular invasion at HP exam (six cases), perineural invasion at HP exam (six cases), and invasion of the ganglion (three N3b cases and two N1 cases). Conclusions: CXPA is a neoplasia that, when associated with large tumor volumes or peripheral facial paralysis in particular, is a challenge for both the doctor and patient.

Salivary duct carcinoma

Perineural invasion

10.3390/medicina61010037

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Evoluţia chirurgiei sinusului maxilar: abordurile deschise în era endoscopiei nazale

ORL ro (2024)

Anca-Ionela Cîrstea Maria Dana Gheorghiev Miruna Bratiloveanu Lorena Păun Rareş Oancă

10.26416/orl.65.4.2024.10299

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Semne clinice rare în limfomul non-Hodgkin de cap şi gât

ORL ro (2023)

Anca-Ionela Cîrstea Daniela Vrînceanu Raluca Grigore Mihai Dumitru Maria Dana Gheorghiev

Lymphoma is the second most frequent malignant diagnosis of the head and neck, following squamous cell carcinoma. The most common form of manifestation of lymphomas in the ENT practice is cervical polyadenopathy. This paper presents two cases in which the clinical presentation was not typical for a head and neck lymphoma. The first case presents an ulceration of the tonsillar fossa and a laterocervical lymph node block, while the second case presents a parotid tumor. In both cases, the final diagnosis was non-Hodgkin lymphoma. Lymphoma should be taken into consideration when making the differential diagnosis of a tumor formation in the head and neck, regardless of its ulcerated or hypertrophic, exophytic or infiltrative form. For an accurate and prompt diagnosis, close collaboration between the otorhinolaryngologist and the pathologist is necessary.

Fossa

Cervical lymph nodes

Presentation (obstetrics)

10.26416/orl.59.2.2023.8113

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