Eimear Courtney

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2dfjds

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CCDC 2217536: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Hamad H. Al Mamari J.P. Borel Aobha Hickey Eimear Courtney Julia Merz

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2dfjft

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CCDC 2217534: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Hamad H. Al Mamari J.P. Borel Aobha Hickey Eimear Courtney Julia Merz

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2dfjcr

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CCDC 2217538: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Hamad H. Al Mamari J.P. Borel Aobha Hickey Eimear Courtney Julia Merz

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2dfjhw

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CCDC 2240411: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Si Lok Ko Eimear Courtney Mark E. Light David Jones Gerard P. McGlacken

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2f6bbb

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CCDC 2240956: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Si Lok Ko Eimear Courtney Mark E. Light David Jones Gerard P. McGlacken

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2f6wxg

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Manganese-catalysed C2 allylation and deuteration of indoles in water

Tetrahedron Green Chem (2023)

Si Lok Ko Eimear Courtney Dr Mark Light David J. Jones Dr Gerard P. McGlacken

Mn-catalysed C–H activation has emerged as a useful sustainable methodology for the formation of new C–C bonds. To date most of the protocols are described in organic solvents. Water as solvent, on the other hand, would be highly advantageous, but is usually incompatible with organometallic chemistry. Herein, we describe the C–H activation of indoles using an unmodified, commercially available manganese catalyst in water. Two types of valuable allyl groups can be added and a good substrate scope is described. Substitution of the C-3 group is tolerated, allowing access to medicinally important frameworks, and the reaction works on a gram scale. Finally, harnessing the tolerance of water as the reaction medium, D2O can be used as an inexpensive source of deuterium for the C-2 labelling of indoles.

Functional group

10.1016/j.tgchem.2023.100019

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Regioselective Iridium‐Catalyzed C8‐H Borylation of 4‐Quinolones via Transient O‐Borylated Quinolines

Chemistry - A European Journal (2023)

Hamad H. Al Mamari J.P. Borel Aobha Hickey Eimear Courtney Julia Merz

The quinolone-quinoline tautomerization is harnessed to effect the regioselective C8-borylation of biologically important 4-quinolones by using [Ir(OMe)(cod)]2 as the catalyst precursor, the silica-supported monodentate phosphine Si-SMAP as the ligand, and B2 pin2 as the boron source. Initially, O-borylation of the quinoline tautomer takes place. Critically, the newly formed 4-(pinBO)-quinolines then undergo N-directed selective Ir-catalyzed borylation at C8. Hydrolysis of the OBpin moiety on workup returns the system to the quinolone tautomer. The C8-borylated quinolines were converted to their corresponding potassium trifluoroborate (BF3 K) salts and to their C8-chlorinated quinolone derivatives. The two-step C-H borylation-chlorination reaction sequence resulted in various C8-Cl quinolones in good yields. Conversion to C8-OH-, C8-NH2 -, and C8-Ar-substituted quinolones was also feasible by using this methodology.

Borylation

Quinoline

Moiety

Quinolone

10.1002/chem.202301734

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CCDC 2217533: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Hamad H. Al Mamari J.P. Borel Aobha Hickey Eimear Courtney Julia Merz

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2dfjbq

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CCDC 2217532: Experimental Crystal Structure Determination

The Cambridge Structural Database (2023)

Hamad H. Al Mamari J.P. Borel Aobha Hickey Eimear Courtney Julia Merz

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc2dfj9p

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Eimear Courtney

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