Yoshiro Wada

Nara Medical University

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Kiyoshi Kidouchi

Showa General Hospital

Toshiaki Yamanaka

Nara Medical University

Taeko Ito

Nara Medical University

Satoshi Sumi

Toyota Technological Institute

Hajime Togari

Kinjo Gakuin University

Tomoyuki Shiozaki

Nara Medical University

Naruji Sugiyama

Aichi Medical College for Physical and Occupational Therapy

Masanori Kobayashi

Nippon Veterinary and Life Science University

Tadashi Kitahara

Nara Medical University

Tadashi Kitahara

Nara Medical University

Cooperative Institutions

Nagoya City University

130

Nagoya University

Tohoku University

The University of Tokyo

Osaka University

Kyoto University

Mizuho (Japan)

Nara Medical University

Hokkaido University

Nara Medical University Hospital

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Development of Histidinemic Patients: Follow‐Up Study of Five Cases with Neuropsychological Symptoms

Pediatrics International (1987)

Michiko Ishikawa Hisako Saito Hideko Morishita Tamiko Ito Taiji Kato

Abstract We described the general clinical course of histidinemia in a previous report. Here, we report on five patients having particular problems in the developmental aspects. Case 1 was found to have histidinemia at the age of 3 years during a clinical survey of the nature of his neurological symptoms. He has been followed up for seven years. He developed poorly in verbal expression. Case II was detected by newborn mass screening. The psychomotor development was apparently normal, but in detail, the development of fine motor and cognitive function was insufficient during the follow‐up period. Consequently, a developmental lag in visual perception, visual motor perception and spatial perception were noted in this case. Cases III, IV and V were each 3 years old, and were also diagnosed as histidinemic by newborn mass screening test; scanty attachment and various kinds of autistic behavior were noted during their clinical course. These five cases were clinically different from other non‐symptomatic patients with histidinemia. It is important to study the pathogenesis of such psychomotor abnormalities from the viewpoint of psychological care for the children.

10.1111/j.1442-200x.1987.tb00343.x

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Citations (4)

Copper-binding proteins in the liver and kidney from the patients with Menkes' kinky hair disease.

The Tohoku Journal of Experimental Medicine (1983)

Makoto Yazaki Yoshiro Wada Yutaka Kojima Akemi Tanaka Gen Isshiki

YAZAKI, M., WADA, Y., KOJIMA, Y., TANAKA, A., ISSHIKI, G., KAWAMURA, N. and HIROSE, M. Copper-Binding Proteins in the Liver and Kidney from the Patients with Menkes' Kinky Hair Disease. Tohoku J. exp. Med., 1983, 139 (1), 97-102 - Copper-binding proteins in the tissues from the patients with Menkes' kinky hair disease were examined by gel filtration on a Sephadex G-75 column. In the kidney, major part of copper was found to bind to low molecular weight protein, which corresponded chromatographically to metallothionein. This copper-binding protein contained a large amount of copper and a small amount of zinc. Cu: Zn ratio of this protein was different from that of metallothionein found in the fetal liver. In the liver of the same patient, however, there was no increase of copper bound to this protein.

Sephadex

Metallothionein

10.1620/tjem.139.97

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Citations (7)

[Clinical studies on pulsatile perfusion cooling in open heart surgery].

PubMed (1986)

Yoshiro Wada Yukio Sasaki M Kadowaki K Kitaura Keiji Nishiyama

Pulsatile flow

Source

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Citations (2)

Why and how we perceive tilt perception in space—an experimental plan during long-term space lifein the international space station—

Equilibrium Research (2011)

Yoshiro Wada

We are planning an experiment to determine why and how we perceive tilt in space. Tilt perception was thought to disappear in space, where gravity does not exist as a reference for tilt. Nevertheless, astronauts reported perceived head roll-tilt and ocular counter-rolling (OCR) in a centrifuge experiment in space. To explain these unexpected findings, during long-term space life we will measure the subjective visual body axis (SVBA) and OCR at various body roll-tilt angles relative to the inner-cabin vertical, with and without head roll-tilt relative to the body, with and without visual information. We are also currently performing ground-based experiments to collect control data. In this article, we introduce these space and terrestrial experiments.

Head tilt

10.3757/jser.70.115

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Citations (1)

Urinary pyrimidine analysis in healthy newborns, infants, children, adults and patients with congenital metabolic diseases

Pediatrics International (2000)

Masami Asai Satoshi Sumi Kiyoshi Kidouchi Hiromi Imaeda Hajime Togari

Abstract Background : In previous reports, the reference range for urinary pyrimidine was determined on the basis of a small number of samples, with data for only a few patients being reported. In the present study, we measured urinary pyrimidine compounds in 25 healthy newborns, 33 healthy infants, 130 healthy children and 166 healthy adults. In addition, we also analyzed urinary pyrimidine compounds in various patients with abnormal pyrimidine metabolism, such as congenital pyrimidine metabolism disorders and urea cycle disorders. Methods : We analyzed urines by high‐performance liquid chromatography with column switching. Analyses were performed with both a reverse‐phase column and an anion‐exchange column. The columns were connected by a column switch, with all systems being controlled automatically by a computerized system controller. Results : The excretion of pyrimidine compounds in patients with abnormal pyrimidine metabolism (containing heterozygotes) was out of our reference ranges. Conclusions : These results suggest that urinary pyrimidine analysis is a useful index for the diagnosis of pyrimidine metabolism disorders, urea cycle disorders and these heterozygotes. Based on this large‐group analysis of healthy individuals, we were able to determine the reference ranges of urinary orotic acid, dihydrouracil and uracil for each age group.

Orotic acid

Pyrimidine metabolism

Uracil

10.1046/j.1442-200x.2000.01274.x

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Citations (11)

Accuracy assessment of kinect body tracker in instant posturography for balance disorders

Hiroyuki Funaya Tomohiro Shibata Yoshiro Wada Toshiaki Yamanaka

The accuracy of the body-tracking algorithm of Microsoft Kinect SDK was investigated with the aim to apply the device to the medical care of balance disorders. We focused on the inclination of body posture, assuming that Kinect is used for instant posturography in the test of balance. Subjects were asked to participate in several balance tests and the positions of motion-capture markers on subjects were recorded simultaneously with Kinect body-tracking measurements. After calibrating coordinates and compensating for temporal delay between the two sensor systems using a hybrid marker, the correspondence between the body-part locations of Kinect and those of motion capture was modeled by a linear combination model of neighboring markers with optimal parameters, which were estimated according to the criterion of trajectory minimization. The experiment for six healthy adults showed that our method can track body motion at the accuracy required for standard balance tests.

Posturography

Motion Capture

Tracking (education)

Balance disorders

Body segment

10.1109/ismict.2013.6521731

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Citations (18)

Clinical and Biochemical Findings of a Patient with Thanatophoric Dysplasia Type I: Additional Finding of Dicarboxylic Aciduria

The Cleft Palate-Craniofacial Journal (2002)

Kazuki Okajima Kiyofumi Asai Toshimitsu Niwa Shigeru Ohki Hisanori Sobajima

Objective A long-surviving thanatophoric dysplasia type I patient to age of 6 years is presented. Results and Conclusions Molecular studies revealed a heterozygous point mutation, S249C in the fibroblast growth factor receptor 3 gene. Most of the clinical course was similar to previous reports, including hearing loss and acanthosis nigricans. Abnormal urinary excretion of dicarboxylic acids and 3-hydroxydicarboxylic acids was observed. We hypothesize that this was a consequence of the FGFR3 mutation.

Acanthosis Nigricans

10.1597/1545-1569_2002_039_0246_cabfoa_2.0.co_2

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Citations (3)

Construction of a Mixed Reality Environment for Evaluating an Illusory Sense of Linear Acceleration Based on Vergence Eye Movement

The Journal of The Institute of Image Information and Television Engineers (2010)

Sei Ikeda Yoshiro Wada Tomohiro Shibata

We describe a mixed reality (MR) environment for testing a novel index of an illusory sense of linear acceleration. The index is based on a measurement of the user's vergence eye movement, which is defined as the simultaneous and collaborative movement of both eyes. For evaluating the illusory sense of linear acceleration, we developed an MR environment consisting of a large hemisphere display and a motion chair, and we conducted eye-movement measurements. In this experiment, subjects sat on a motion chair and were instructed to look around the center of a display. We considered four conditions in a 2 × 2 factorial design with the factors of video motion and chair motion. The video was recorded out of doors by using a car, and the chair was either tilted or not tilted. We observed the significantly faster eye convergence when the video was played (not static) and when the chair was tilted, providing support for the usability of our MR environment.

Vergence (optics)

Linear motion

Linear acceleration

10.3169/itej.64.244

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Citations (1)

Globoid Cell Leukodystrohy: The First Case with Antemortem Diagnosis in Japan

The Tohoku Journal of Experimental Medicine (1975)

Yoshiro Wada Tsuneo Arakawa Nobukazu Chida Akira Onuma Hiroshi Nakagawa

A Japanese boy was diagnosed as globoid cell leukody-strophy on the basis of a marked decrease in the galactocerebroside β-galactosidase activity in the leukocytes and the serum when one year and two months old. At autopsy when 1 year and 10 months, microscopic findings were characteristic for those of globoid cell leukodystrophy. Galactocerebroside β-galactosidase activities of leukocytes and sera of his father and mother were found to be half those of control subjects, thus it suggested the parents being heterozygotes of the disease.

Galactocerebroside

Heterozygote advantage

10.1620/tjem.115.53

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Citations (1)

Vertigenous Patients during the Past 10 Years in Our Clinic

Practica oto-rhino-laryngologica Suppl (1990)

Isao Koh Yoshiro Wada Katsuya Akioka Nobuya Fjita Yoshiyuki Kitaoku

A statistical analysis was made on 1820 patients who visited our clinic, complaining of vertigo and dizziness from 1977 to 1986.The number of patients was increasing, especially patients over 65 years old. Otological origin occupied 32% (Meniere's disease 10%), and unknown origin 47%. Vestibular dysfunction due to ototoxic drugs (KM. SM), cerebrovascular disorder, and vertigo following head trauma were predominant in males, vertigo due to hypotension was in females.Brain tumor and origin unknown vertigo were predominant in the patients under 15years old, sudden deafness with vertigo in those between 15 and 65 years old, vestibular dysfunction due to ototoxic drugs (SM. KM) and vertigo due to hypotension in those over 65 years old.Half of the patients complained of vertigo and one third complained of dizziness.

10.5631/jibirinsuppl1986.1990.supplement37_51

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Citations (0)