BACKGROUND Post-stroke depression (PSD) is the most common psychiatric disorder after stroke and affects recovery of neurological function, ability to return to society, and quality of life of the survivors. Telehealth has been shown to improve depressive symptoms and quality of life of post-stroke patients. However, evidence from clinical trials has not been systematically synthesized. OBJECTIVE This study aims to systematically evaluate the effectiveness of telehealth interventions in reducing depression and anxiety symptoms of post-stroke depression. METHODS The Cochrane Library, PubMed, CINAHL, PsycINFO, CNKI and Wanfang Database were searched to identify randomized controlled trials (RCTs) on effectiveness of telehealth interventions for post-stroke depression from inception to November 30, 2021.The quality of included studies was assessed using the Cochrane risk of bias tool. Data extraction and quality assessment were conducted by two reviewers independently. RevMan 5.4 software was used for Meta-analysis. Data would be synthesized by either the fixed-effect (I2≤50%) or random-effect (I2>50%) model according to a heterogeneity test. RESULTS A total of 10 studies with 1717 participants were included, of which 8 were eligible for meta-analysis. Compared with the control group, the anxiety score of the telemedicine group was lower, with statistical significance (SMD=-1.05, 95%CI-1.22 to -0.89, P<.001), while no significant differences in scores in depression (SMD=-0.16, 95%CI-0.67 to 0.36, P=.54), quality of life (SMD=0.00, 95%CI-0.18 to 0.18, P=.99), limb function (SMD=0.46, 95%CI-0.26 to 1.18, P=.21), and daily living ability (SMD=1.95, 95%CI-1.39 to 2.29, P=.67) were observed. CONCLUSIONS Telehealth interventions could availably reduce anxiety symptoms in post-stroke patients, while it had equal salutary effects on depression with the conventional nursing. Therefore large-scale, high-quality randomized controlled trials are needed to further explore the potential of telehealth interventions in terms of mental health for post-stroke patients. CLINICALTRIAL PROSPERO CRD42021291311
… (ECL) systems require highly robust organic emitters in the radical form.In their Research Article (e202301109), Keishiro Tahara, Masaaki Abe, and co-workers used the classical Lewis acid B(C 6 F 5 ) 3 as an electrochemical protector of donoracceptor emitters, leading to the discovery of Lewis-pairing-induced ECL enhancement.The Lewis acid also converted the molecular arrangements of the emitters, playing a unique role in crystalline-film ECL. ElectrocatalysisIn their Research Article (e202300226), Miao Zhong and co-workers developed an electrode-structureengineering strategy to achieve efficient, selective, and stable CO 2 reduction with high CO 2 utilization. Drug DeliveryIn their Communication (e202301566), Weiwei Gao, Liangfang Zhang et al. report a nanodisc formulation made with natural human red blood cell membrane and demonstrate its robust application for bacterial toxin neutralization.
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ABSTRACT Background Adverse childhood experiences (ACEs) are known contributors to lifelong mental health challenges. Despite studies linking ACEs to increased risk of adverse postpartum mental health outcomes, a systematic review on the occurrence of postpartum post‐traumatic stress disorder (PTSD) in women with ACEs is lacking. Methods A systematic search was conducted in seven databases to retrieve studies from inception to January 31, 2024. A random‐effects model was used to quantify weighted estimates of postpartum PTSD incidence. Statistical analysis was conducted using R software. Results Seven studies were included in the system review. One study was identified as an outlier and excluded from the meta‐analysis. Among the six remaining studies, 1186 women exposed to ACEs were identified, with 249 of them experiencing postpartum PTSD. The estimated incidence of postpartum PTSD among women exposed to ACEs was 22.6% (95% confidence interval [CI] 16.1%–29.8%). Subgroup analysis revealed significant variations in incidence depending on study settings ( p < 0.01) and PTSD assessment methods ( p < 0.01). Due to multicollinearity among the primary variables, a meta‐regression to identify factors influencing study heterogeneity was not conducted. Conclusion The incidence of postpartum PTSD was 22.6% in women with ACEs, higher than that observed in the general obstetric population. This finding suggests the need to provide comprehensive postpartum care for these women.
Postpartum post-traumatic stress disorder (PTSD) is a debilitating condition that can arise following childbirth. Despite a growing body of research on postpartum mental health, the relationship between social support and postpartum PTSD remains unclear. This study aimed to assess the association between social support and postpartum PTSD. A prospective cohort study was conducted at a tertiary hospital in Guangdong province of China between November 2022 and April 2023. Eligible mothers were assessed for social support using the Social Support Rating Scale (SSRS) at three days postpartum and for PTSD using the Perinatal Post-Traumatic Stress Disorder Questionnaire (PPQ) at 42 days postpartum. The association between social support and postpartum PTSD was analyzed using multiple linear and log-binomial regression, with adjustments for potential confounders. Forty-six of 560 (8.2%) mothers developed PTSD within 42 days postpartum. Scores for subjective support (β=-0.319, P < 0.001), objective support (β=-0.327, P < 0.001), support availability (β=-0.285, P < 0.001), and overall social support score (β=-0.428, P < 0.001) were inversely associated with PTSD scores. Compared to mothers in the 1st quartile of the overall social support score, those in the 2nd, 3rd, and 4th quartiles had adjusted relative risks of 0.39 (95% confidence interval [CI]: 0.21–0.74), 0.20 (95% CI: 0.09–0.45), and 0.10 (95% CI: 0.03–0.33), respectively, of developing PTSD. An inverse linear trend in the risk of PTSD was observed with increasing social support (P-trend < 0.001). Social support may have a protective effect against postpartum PTSD, with practical implications for interventions targeting various dimensions of support.