Fernando Moreto

Universidade Estadual Paulista (Unesp)

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Roberto Carlos Burini

Medecell (Brazil)

Camila Renata Corrêa

Universidade Estadual Paulista (Unesp)

Artur Júnio Togneri Ferron

Universidade Estadual Paulista (Unesp)

Fabiane Valentini Francisqueti-Ferron

Universidade Estadual Paulista (Unesp)

Jéssica Leite Garcia

Universidade Estadual Paulista (Unesp)

Ana Lúcia Anjos Ferreira

Universidade Estadual Paulista (Unesp)

Igor Otávio Minatel

Universidade Estadual Paulista (Unesp)

Rodrigo Minoru Manda

Brazilian Academy of Sciences

Mariane Róvero Costa

Universidade Estadual Paulista (Unesp)

Carol Cristina Vágula de Almeida Silva

Universidade Estadual Paulista (Unesp)

Cooperative Institutions

Universidade Estadual Paulista (Unesp)

Universidade de São Paulo

Medecell (Brazil)

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Western University of Health Sciences

ORCID

Universidade Estadual de Campinas (UNICAMP)

Tufts University

Harvard University

Universidade Federal de São Paulo

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Gamma-oryzanol reduces renal inflammation and oxidative stress by modulating AGEs/RAGE axis in animals submitted to high sugar-fat diet

Brazilian Journal of Nephrology (2021)

Fabiane Valentini Francisqueti-Ferron Artur Júnio Togneri Ferron Alessandra Altomare Jéssica Leite Garcia Fernando Moreto

The receptor for AGEs (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface receptors expressed in many organs, among them, the kidneys. When activated, RAGE leads to a sequence of signaling that results in inflammation and oxidative stress, both involved in kidney disease pathogenesis. Gamma-oryzanol (γOz) comprises a mixture of ferulic acid (FA) esters and phytosterols (sterols and triterpene alcohols) mainly found in rice, with antioxidant and anti-inflammatory activities.To evaluate the effect of γOz to reduce renal inflammation and oxidative stress by modulating AGEs/RAGE axis in animals submitted to a high sugar-fat diet.Male Wistar rats (±187g) were randomly divided into two experimental groups: control (n = 7 animals) and high sugar-fat diet (HSF, n = 14 animals) for 20 weeks. After this period, when the presence of renal disease risk factors was detected in the HSF group (insulin resistance, dyslipidemia, increased systolic blood pressure and obesity), the HSF animals were divided to begin the treatment with γOz or continue receiving only HSF for 10 more weeks.No effect of γOz on obesity and metabolic parameters was observed. However, kidney inflammation and oxidative stress decreased as soon as RAGE levels were reduced in HSF + γOz.It is possible to conclude that the gamma- oryzanol was effective in reducing inflammation and oxidative stress in the kidney by modulating the AGEs/RAGE axis.

RAGE

Dyslipidemia

10.1590/2175-8239-jbn-2021-0002

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Citations (6)

Reduction of metabolic syndrome by a lifestyle‐modification program is accompanied by improvements of aerobic fitness and plasma antioxidant markers

The FASEB Journal (2013)

Fernando Moreto Rodrigo Minoru Manda Kátia Cristina Portero‐McLellan Camila Renata Corrêa Roberto Carlos Burini

Lifestyle change is an effective strategy in the primary care of metabolic syndrome (MetS). To verify the effects of a lifestyle‐modification program (LISC) on MetS and its co‐morbidities, 60 subjects (53yrs, 84% women) clinically approved to attend a 20wks intervention in the LISC “Move for Health” were submitted to weekly nutritional counseling and daily (3–5 times/wk) physical activities. Before and after intervention there were performed anthropometric, clinical, physical (with VO 2max test) and laboratorial assessments including plasma analysis of total antioxidant performance (TAP), reduced (GSH) and oxidized (GSSG) glutathione, malonyldialdehyde (MDA) and C‐reactive protein (CRP). For statistical analysis we used paired‐t or signed rank tests with p<0.05 by SigmaStat 3.5 software. The reduction of MetS (47 to 40%) was followed by reductions in waist circumference (97±16 to 94±14cm) and elevations in plasma HDLC levels (47±12 to 49±12mg/dL). VO 2max increased (30±5 to 33±5.2mL/kg/min) as well as plasma TAP (50±9 to 52±9%), reduced GSH (5.9±1.9 to 6.9±1.9μmol/L) with a decrease of GSSG/GSH ratio (0.13[0.08–0.17] to 0.10[0.07–0.13]). No differences in insulin resistance (fasting glucose and HOMA‐IR), inflammatory (CRP) and pro‐oxidant markers (MDA and GSSG) were observed. This LISC was effective in lowering MetS probably secondary to raising either cardiorespiratory fitness and/or antioxidant potential. Supported by CAPES, CNPq

Aerobic Exercise

10.1096/fasebj.27.1_supplement.1067.9

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Dietary factors associated with metabolic syndrome and its components in overweight and obese Brazilian schoolchildren: a cross-sectional study

Diabetology & Metabolic Syndrome (2016)

Ana Elisa Madalena Rinaldi Gleice Fernanda Costa Pinto Gabriel Fernando Moreto José Eduardo Corrente Kátia Cristina Portero McLellan

The metabolic syndrome (MS) has been assessed since childhood mainly because of the nutritional and epidemiological transition that has occurred worldwide. Our objectives were to explore the MS and its components according to anthropometric and demographic factors and to assess the relationship among MS components and dietary characteristics in overweight and obese schoolchildren. This was a cross-sectional study which included 147 schoolchildren (aged 6–10 years) from three elementary schools, with body mass index (BMI) higher than the 85th percentile. Sexual maturation stages, anthropometric measures (weight, height, skinfold thickness and waist circumference), biochemical data (glucose, HDL-C and triacylglycerol), blood pressure and dietary intake were assessed. The metabolic syndrome was diagnosed if three or more of the following components were presented: waist circumference ≥90th age and sex-specific cut-off, blood pressure ≥90th age, sex and height-specific cut-off, glucose ≥100 mg/dL, HDL-C ≥ 40 mg/dL and triacylglycerols ≥ 110 mg/dL. The dietary intake was assessed by three non-consecutive 24-h recalls. The T test, Kruskal–Wallis and multiple linear regression analysis were applied to assess MS components and dietary intake. The MS percentage was 10.2 % and it was higher in obese children and ones with high body fat percentage. The waist circumference was the main altered component of MS and 62 % of overweight schoolchildren showed at least one altered component of MS. The components of metabolic syndrome associated with dietary intake were triacylglycerol (positive association with saturated and monounsaturated fat, whole-milk products and processed foods and negative associated with legumes and polyunsaturated fat), glycemia (positive association with processed foods and negative with cereals), HDL-C (positive association with vegetables and greens) and waist circumference was negative associated with protein. The frequency of MS was higher in obese than overweight schoolchildren and the frequency of at least one MS component was high in more than half of our subjects. The waist circumference was the most frequent among all other components. The triacylglycerol and glycemia were the most frequent MS components associated with dietary intake. Unprocessed food was considered a protective dietary factor for MS metabolic components and processed food with high percentage of sugar and saturated fat was a risk factor for MS metabolic components.

Cross-sectional study

10.1186/s13098-016-0178-9

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Citations (39)

Additional Benefits of W-3 Oil Supplements on Metabolic Syndrome Care in Exercise Protocol Intervention

Medicine & Science in Sports & Exercise (2012)

Erick P. de Oliveira Lidiana C. Talon Fernando Moreto Viviane M. R. Acerra Kátia Cristina Portero McLellan

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Fructose Consumption Alters Biogenic Amines Associated with Cardiovascular Disease Risk Factors

Figshare (2023)

Fabiane Valentini Francisqueti-Ferron Matheus Antônio Filiol Belin Thiago Luiz Novaga Palacio Artur Júnio Togneri Ferron Jéssica Leite Garcia

Abstract Background Cardiovascular diseases (CVD) are the major cause of mortality worldwide, whose most prominent risk factor is unhealthy eating habits, such as high fructose intake. Biogenic amines (BAs) perform important functions in the human body. However, the effect of fructose consumption on BA levels is still unclear, as is the association between these and CVD risk factors. Objective This study aimed to establish the association between BA levels and CVD risk factors in animals that consumed fructose. Methods Male Wistar rats received standard chow (n=8) or standard chow + fructose in drinking water (30%) (n=8) over a 24-week period. At the end of this period, the nutritional and metabolic syndrome (MS) parameters and plasmatic BA levels were analyzed. A 5% level of significance was adopted. Results Fructose consumption led to MS, reduced the levels of tryptophan and 5-hydroxitryptophan, and increased histamine. Tryptophan, histamine, and dopamine showed a correlation with metabolic syndrome parameters. Conclusion Fructose consumption alters BAs associated with CVD risk factors.

Consumption

10.6084/m9.figshare.23544483

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Quantitative proteomics study of carnosine effect in an animal model of Western diet‐induced nonalcoholic fatty liver disease

Journal of Biochemical and Molecular Toxicology (2024)

Fernando Moreto Jéssica Leite Garcia Ana Lúcia Anjos Ferreira Silvia Radrezza Mariane Róvero Costa

Abstract The nonalcoholic fatty liver disease (NAFLD), which is closely related to westernized dietary (WD) patterns, displays a rising epidemiological and economic burden. Since there is no pharmacological therapy approved for this disease, mechanistic studies are warranted. In this work, we investigated the action of carnosine (CAR), a natural dipeptide with several protection roles against oxidative stress in the liver of NAFLD rats. NAFLD was induced by WD‐rich sugars and fat, verifying the histological evidence of steatosis. As intraperitoneal administration of CAR reversed liver steatosis, the protein profiles of NAFLD liver and CAR NAFLD liver were evaluated by label‐free proteomics approach. A total of 2531 proteins were identified and the 230 and 276 were significantly up‐ and downregulated, respectively, by CAR treatment of NAFLD rats and involved in fundamental pathways such as oxidative stress and lipid metabolism. Perilipin 2 and apolipoprotein E, components of the plasma membrane of vesicle, resulted in highly downregulated in the CAR‐treated NAFLD liver. The advanced bioanalytical approach demonstrated the efficacy of CAR in overcoming the main symptoms of NAFLD, ameliorating the steatosis in the liver.

Steatosis

Carnosine

Liver disease

10.1002/jbt.23644

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Citations (1)

Gamma-oryzanol as a potential modulator of oxidative stress and inflammation via PPAR-y in adipose tissue: a hypothetical therapeutic for cytokine storm in COVID-19?

Molecular and Cellular Endocrinology (2020)

Fabiane Valentini Francisqueti-Ferron Jéssica Leite Garcia Artur Júnio Togneri Ferron Erika Tiemi Nakandakare-Maia Cristina Schmitt Gregolin

Cytokine Storm

10.1016/j.mce.2020.111095

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Citations (27)

List of Contributors

Elsevier eBooks (2017)

Ajibola Ibraheem Abioye Jamal Ahmad Alexis Alejandre Deepika Anand O.G. Arinola

10.1016/b978-0-12-809853-0.01002-6

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Consumo de Gama Orizanol Previne a Inflamação Hepática Induzida pelo Consumo de Dieta Rica em Açúcar e Gordura

SILVA J P D C Artur Júnio Togneri Ferron E T N MAIA Jéssica Leite Garcia Juliana Silva Siqueira

10.26626/978-65-5668-019-4c0032

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Influência da adiposidade sobre o risco inflamatório em pacientes com glicemia de jejum alterada

Revista de Nutrição (2009)

João Felipe Mota Wilson L. Medina Fernando Moreto Roberto Carlos Burini

OBJETIVO: Investigar as alterações dos marcadores inflamatórios em obesos com glicemia de jejum alterada. MÉTODOS: Foram avaliados 125 indivíduos adultos tendo sido pesquisados: Índice de Massa Corporal, circunferência da cintura, glicemia de jejum, proteína C reativa ultra-sensível, ácido úrico e homocisteína. Os grupos apresentando glicemia de jejum normal (grupo 1) e glicemia de jejum alterada (grupo 2) foram comparados entre si e em associação aos subgrupos de obesos, sobrepesos e eutróficos. RESULTADOS: O grupo 2 apresentou maiores valores de circunferência da cintura (p<0,05), principalmente quando associados ao excesso de peso. Adicionalmente, o grupo 2 mostrou valores de proteína C reativa e ácido úrico superiores, sendo os dos obesos maiores que os com sobrepeso e os eutróficos, enquanto a homocisteína foi semelhante entre obesos, com sobrepeso e eutróficos. O Índice de Massa Corporal correlacionou-se positivamente com ambos ácido úrico (r=0,39, p<0,01) e proteína C reativa (r=0,37; p<0,01). A circunferência da cintura apresentou correlação apenas com o ácido úrico (r=0,53, p<0,01). Porém, a correlação entre Índice de Massa Corporal e proteína C reativa foi significante no grupo 2 (r=0,66, p<0,01), mas não no grupo 1 (r=0,25, p>0,05). O mesmo resultado foi encontrado em relação à circunferência da cintura e à proteína C reativa, que se correlacionaram significantemente somente na presença de glicemia de jejum alterada (r=0,40, p<0,05). Na regressão logística, a circunferência da cintura foi a variável explicativa (11%, p<0,01) da alteração da glicemia de jejum. CONCLUSÃO: Os estados pró-oxidativo e pró-inflamatório estiveram significantemente associados à glicemia de jejum alterada na presença de adiposidade corporal.

10.1590/s1415-52732009000300005

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Citations (7)