Sylvia Talaat Kamal

Ain Shams University

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Serum Adiponectin and Resistin Levels in Association with Bronchial Asthma in Adults

QJM (2021)

Salwa Seddik Hosny Mohamed Nazmy Farres Nermine Melek Amira Ramadan El Mahdi Sylvia Talaat Kamal

Abstract Background The association between obesity and bronchial asthma has been demonstrated by many studies, either observational or interventional studies in both children and adults. However, the mechanism behind this association is still unknown. Many studies proposed that adipokines provide a mechanistic link between asthma and obesity. Adipokines may be proinflammatory (e.g. resistin) or anti-inflammatory (e.g. adiponectin). The Effects of these adipokines on the lungs have been proposed to have the potential to cause or exacerbate existing asthma. Objective To determine serum levels of adiponectin and resistin in adult asthmatics in comparison to non-asthmatics. Methods 96 subjects were included in this study; 64 with bronchial asthma and 32 healthy individuals as control group. All the patients were subjected to the following: Full history, clinical examination, calculation of body mass index (BMI), waist/hip ratio, body fat percentage, asthma control test (ACT), Skin prick test (SPT) for common allergens, CBC, Total IgE, Pulmonary functions and measurement of serum adiponectin and resistin after overnight fasting by ELISA. Results The present study proved that patients with bronchial asthma had higher levels of serum Adiponectin and serum Resistin in comparison to control subjects. Conclusion Serum Resistin is increased in bronchial asthma and act as proinflammatory marker while serum Adiponectin might not act as anti-inflammatory in asthma in fact, it may exacerbate inflammation. Interaction between different adipokines need to be further studied.

Resistin

Proinflammatory cytokine

10.1093/qjmed/hcab100.099

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Prevalence of Selective IgA Deficiency in a Sample of Egyptian Patients with Type1 Diabetes Mellitus

The Egyptian Journal of Hospital Medicine (2021)

Hoda Mohamed Nafee Elsayed Fawzia Hassan Abou Ali Dina Sayed Sheha Nesma Ali Ibrahim Yasmin Sayed Sharawy

Background: Selective Immunoglobulin A deficiency (SIgAD) is known to be one of the most frequent primary immunodeficiency diseases.Several studies worldwide confirm the increased frequency of this disease among type 1 diabetes mellitus (T1DM), yet this has not been studied in Egypt.Objective: This work aimed to define the prevalence of SIgAD among Egyptian patients with T1DM.Patients and Methods: Fifty patients with T1DM were compared to fifty apparently healthy individuals.Serum levels of IgA, IgG, and Immunoglobulin M (IgM) levels were measured by Nephelometry to all participants.Results: The mean age of the diabetic group was 24.5 ± 5.3 years.Thirty out of fifty patients with T1DM (60%) were diagnosed as SIgAD with, female predominance (66.7% of SIgAD).We also found a significant relationship between SIgAD and diabetic ketoacidosis (P-value<0.001).Serum IgA levels were positively correlated to IgG and IgM. Conclusion:The current study displays 60% prevalence of SIgAD among adult Egyptians with T1DM, which is higher than stated in other countries.

10.21608/ejhm.2021.209971

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Anti-ficolin-2 Antibody: Could it be a Predictor of Proliferative Lupus Nephritis in Lupus Patients?

The Egyptian Journal of Hospital Medicine (2021)

Sylvia Talaat Kamal Mohamed Nazmy Farres Rehab Ali Ibrahim Ibrahim Sami Ibrahim Fatma Abdelrahman Ahmed

Background: Nephritis is a challenging domain of systemic lupus erythematosus (SLE).There is a growing need for identification of a non-invasive marker for diagnosing and monitoring nephritis.Objective: To explore the relevance of using anti-ficolin-2 antibody (Anti-FCN2) as a biomarker for detecting lupus nephritis (LN), and its relation to renal biopsy histopathology and disease activity.Patients and Methods: Sixty SLE patients were compared to 30 apparently healthy individuals.Thirty of the patients were LN patients (documented by a recent renal biopsy).Full history, examination and laboratory investigations were done.Activity was assessed by SLE disease activity index (SLEDAI) score, and Anti-FCN2 titer was measured by enzyme-linked immunosorbent assay technique (ELISA).Results: Forty-four of our SLE patients were in disease activity by SLEDAI score.Anti-FCN2 titer was significantly higher among SLE patients compared to control group (p value <0.001).It was also higher among patients with high disease activity compared to those with low disease activity and cutoff value was at 37 ng/ml (p value is <0.001).Anti-FCN2 titer was significantly higher among patients with LN compared to those without LN (p value is <0.001) with best cutoff value at 72.50 ng/ml.Regarding LN patients, it was significantly higher among patients with proliferative changes than LN patients with non-proliferative changes (p value is 0.05) with best cutoff value at 155 ng/ml.Conclusion: Anti-FCN2 shows promising results as a biomarker for lupus disease activity, especially regarding LN and proliferative changes.Further longitudinal studies on larger samples are needed to confirm.

10.21608/ejhm.2021.205090

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Anti-Ficolin-2 Antibody: Could It Be a Predictor of Proliferative Lupus Nephritis in Lupus Patients?

QJM (2023)

Sylvia Talaat Kamal Mohamed Nazmy Farres Rehab Ali Ibrahim Ibrahim Sami Ibrahim Fatma Abdelrahman Ahmed

Abstract Background Nephritis is a challenging domain of systemic lupus erythematosus (SLE). There is a growing need for identification of a non-invasive marker for diagnosing and monitoring nephritis. Objective To explore the relevance of using anti-ficolin-2 antibody (Anti-FCN2) as a biomarker for detecting lupus nephritis (LN), and its relation to renal biopsy histopathology and disease activity. Patients and Methods Sixty SLE patients were compared to 30 apparently healthy individuals. Thirty of the patients were LN patients (documented by a recent renal biopsy). Full history, examination and laboratory investigations were done. Activity was assessed by SLE disease activity index (SLEDAI) score, and Anti-FCN2 titer was measured by enzyme-linked immunosorbent assay technique (ELISA). Results Forty-four of our SLE patients were in disease activity by SLEDAI score. Anti-FCN2 titer was significantly higher among SLE patients compared to control group (p value <0.001). It was also higher among patients with high disease activity compared to those with low disease activity and cutoff value was at 37 ng/ml (p value is < 0.001). AntiFCN2 titer was significantly higher among patients with LN compared to those without LN (p value is < 0.001) with best cutoff value at 72.50 ng/ml. Regarding LN patients, it was significantly higher among patients with proliferative changes than LN patients with non-proliferative changes (p value is 0.05) with best cutoff value at 155 ng/ml. Conclusion Anti-FCN2 shows promising results as a biomarker for lupus disease activity, especially regarding LN and proliferative changes. Further longitudinal studies on larger samples are needed to confirm.

Nephritis

10.1093/qjmed/hcad069.432

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A study on serum zonulin in chronic spontaneous urticaria patients.

PubMed (2024)

Sylvia Talaat Kamal Mohamed El-Shayeb Menna Allah Zakaria Abou Elwafa Radwa H A ElAdawy Marwa A. Mohamed

Chronic spontaneous urticaria (CSU) is a widespread disease with a complicated heterogenous pathophysiology. Increased intestinal permeability i.e., leaky gut has been linked to the pathology of many diseases. Zonulin was recently used as a marker for leaky guts. This study aimed to assess the relation between serum zonulin level and CSU and its possible relationship with disease activity. This was a comparative cross-sectional study, which included 97 CSU adult patients and 87 apparently healthy controls. CSU patients had significant lower zonulin level than controls (p < 0.001). The median of serum zonulin level was equal to 2.93 ng/ml with interquartile range (IQR) (1.40-4.19) in the CSU group and of 3.92 ng/ml with IQR (2.97-4.69) in the control group. We found a positive correlation between serum zonulin and C-reactive protein with Pearson correlation coefficient of 0.2, (p=0.04). No significant correlation was found between serum zonulin level and urticaria activity score 7 or total immunoglobulin E level. In conclusion, this study found that serum zonulin level is lower in CSU patients than in controls which could be attributed to food restriction, severity of the CSU disease and/or drug intake in the CSU cases.

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Assessment of serum levels of adiponectin and resistin in adult patients with asthma

Egyptian Journal of Chest Diseases and Tuberculosis (2021)

Salwa Seddik Hosny Mohamed Nazmy Farres Nermine Melek Sylvia Talaat Kamal Marwa Rushdy El Najjar

Introduction The mechanisms connecting obesity and asthma are complex. Mechanical and inflammatory factors have been proposed. Adipose tissues secrete various adipokines. Some are proinflammatory such as resistin, whereas others are anti-inflammatory such as adiponectin. We aimed to assess the serum levels of adiponectin and resistin in patients with asthma and correlate them with asthma control and severity as well as obesity parameters of the participants. Patients and methods This case–control study included 64 patients with asthma and 24 healthy controls. They were all subjected to anthropometric measurements, asthma control test, pulmonary function tests, skin prick test, and total serum immunoglobulin E levels. Serum adiponectin and resistin concentrations were measured. Results Adiponectin and resistin levels were significantly higher among patients with asthma than controls ( P <0.001). Serum resistin levels were significantly higher in obese patients with asthma than nonobese ( P <0.001), whereas adiponectin levels were not different between the two subgroups. Serum adiponectin level was positively correlated with the duration of asthma, forced expiratory volume in 1 s /forced vital capacity ratio, and resistin level, whereas resistin level was positively correlated with age, sex, and body fat percentage. Resistin/adiponectin ratio was positively correlated with body fat percentage. Conclusion Adiponectin and resistin levels were higher in patients with asthma. Moreover, resistin was higher in obese than nonobese patients with asthma. These findings could provide novel insights into their role in asthma and their potential use as therapeutic targets.

Resistin

Proinflammatory cytokine

Vital capacity

10.4103/ejcdt.ejcdt_142_20

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Citations (3)