Pedro Azcárate

Clinica Universidad de Navarra

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Gorka Bastarrika

Clinica Universidad de Navarra

Javier Bermejo

Hospital General Universitario Gregorio Marañón

Luis Javier Alonso

Hospital General Universitario Gregorio Marañón

Patricia Muñóz

Hospital General Universitario Gregorio Marañón

Irene Rovira

Universitat de Barcelona

Adrián Téllez

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Enrique Oliva

Hospital Universitario Ramón y Cajal

Eduard Quintana

Hospital Clínic de Barcelona

Antonio Sánchez-Porto

Hospital Universitario Puerta de Hierro Majadahonda

Felicitas Elena Calvo

Hospital Txagorritxu

Cooperative Institutions

Instituto de Salud Carlos III

188

Centro de Investigación Biomédica en Red

188

Hospital General Universitario Gregorio Marañón

164

Universitat de Barcelona

140

Hospital Clínic de Barcelona

116

Universidad Complutense de Madrid

114

Universitat Autònoma de Barcelona

108

Centro de Investigación en Red en Enfermedades Cardiovasculares

107

Clinica Universidad de Navarra

Hospital Universitario Puerta de Hierro Majadahonda

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[Advances in ischaemic heart disease].

PubMed (2006)

E Alegría Á. Velasco Pedro Azcárate

Atherothrombosis is a key concept in our new pathophysiologic understanding of cardiovascular disease. It has led to new preventive strategies, both pharmacologic and lifestyle-related, to more specific treatments and to emerging imaging modalities.

Ischaemic heart disease

Modalities

Pathophysiology

Therapeutic modalities

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Citations (1)

Poster session IV * Friday 10 December 2010, 14:00-18:00

European Journal of Echocardiography (2010)

Alessandro De Angelis Eva Base W Schmid Martin Andreas U. Weber

10.1093/ejechocard/jeq146

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Citations (0)

Long-term survival (>20 years) following heart transplantation.

PubMed (2012)

Stefano Mastrobuoni A Dell'aquila Pedro Azcárate Gregorio Rábago José Miguel Cisneros

Only a few papers with patients surviving more than 15 years after heart transplantation have been reported. Herein we report the characteristics of patients transplanted between 1984 and 1989 who are long-term survivors (>20 years). Survival after transplant, recipient and donor age and aetiology of heart failure were also compared with patients transplanted in the decades 1990-1999 and 2000-2009.Our Heart Transplant Program Database and medical records of all cardiac transplants performed in our centre from July 1984 to 1989 were reviewed. Primary endpoint of the study was the long-term survival and secondary end points were the incidence of transplant-related complications over time.Forty-five transplants were performed in 1984-1989, 41 patients were male, median age was 46 years (IQR: 39-55), median donor age was 24 years (19-29) and mean graft ischemic time was 134±64 minutes. The actuarial survival of this cohort was 77.8%, 64.4%, 48.9%, 35.6% and 24.2% at 1, 5, 10, 15 and 20 years, respectively. Univariate Cox regression analysis revealed the female gender, the graft ischemic time, the recipient-donor gender mismatch, a diagnosis of diabetes and the number of acute rejection episodes during the first year post-transplant as significant risk factors adversely affecting long-term survival. Cardiac allograft vasculopathy is the main cause of death. The mean recipient and donor age and the graft ischemic time have progressively increased over time but survival has not changed.The long-term outcome of heart transplantation is noteworthy. The main limiting factor for survival is the allograft vasculopathy. Considering the tremendous advances in the immunosuppressive therapy and in the understanding of CAV pathophisyology, we can hope for even better results in the next years.

Univariate analysis

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Citations (22)

Impact of Intermediate Susceptibility to Penicillin on Antimicrobial Treatment and Outcomes of Endocarditis Caused by Viridans and Gallolyticus Group Streptococci

Clinical Infectious Diseases (2023)

Francesc Escrihuela-Vidal Dámaris Berbel Núria Fernández-Hidalgo Laura Escolà‐Vergé Patricia Muñóz

Evidence supporting combination treatment with a beta-lactam plus an aminoglycoside (C-BA) for endocarditis caused by viridans and gallolyticus group streptococci (VGS-GGS) with intermediate susceptibility to penicillin (PENI-I) is lacking. We assessed the clinical characteristics and outcomes of PEN-I VGS-GGS endocarditis and compared the effectiveness and safety of C-BA with third-generation cephalosporin monotherapy.Retrospective analysis of prospectively collected data of a cohort of definite endocarditis caused by penicillin-susceptible and PENI-I VGS-GGS (penicillin minimum inhibitory concentration ranging from 0.25 to 2 mg/L) between 2008 and 2018 in 40 Spanish hospitals. We compared cases treated with monotherapy or with C-BA and performed multivariable analyses of risk factors for in-hospital and 1-year mortality.A total of 914 consecutive cases of definite endocarditis caused by VGS-GGS with complete or intermediate susceptibility to penicillin were included. A total of 688 (75.3%) were susceptible to penicillin and 226 (24.7%) were PENI-I. Monotherapy was used in 415 (45.4%) cases (cephalosporin in 331 cases) and 499 (54.6%) cases received C-BA. In-hospital mortality was 11.9%, and 190 (20.9%) patients developed acute kidney injury. Heart failure (odds ratio [OR]: 6.06; 95% confidence interval [CI]: 1.37-26.87; P = .018), central nervous system emboli (OR: 9.83; 95% CI: 2.17-44.49; P = .003) and intracardiac abscess (OR: 13.47; 95% CI: 2.24-81.08; P = .004) were independently associated with in-hospital mortality among PEN-I VGS-GGS cases, while monotherapy was not (OR: 1.01; 95% CI: .26-3.96; P = .982).Our findings support the use of cephalosporin monotherapy in PEN-I VGS-GGS endocarditis in order to avoid nephrotoxicity without adversely affecting patient outcomes.

Infective Endocarditis

10.1093/cid/ciad375

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Citations (6)

Cuantificación de la función y masa ventricular con secuencias SSFP en tiempo real y respiración libre

Radiología (2008)

Gorka Bastarrika Pablo Domínguez Pedro Azcárate S. Castaño Rodríguez M.E. Fernández Jarne

Ventricular Function

10.1016/s0033-8338(08)71931-3

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Citations (9)

Endocarditis bacteriana

Medicine - Programa de Formación Médica Continuada Acreditado (2009)

Ana Barrero Pedro Azcárate Sara Rodríguez

10.1016/s0304-5412(09)72486-2

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Citations (3)

Prevalence of Colorectal Neoplasms Among Patients With Enterococcus faecalis Endocarditis in the GAMES Cohort (2008–2017)

Mayo Clinic Proceedings (2021)

Juan M. Pericàs Juan Ambrosioni Patricia Muñóz Arístides de Alarcón Martha Kestler

Infective Endocarditis

Enterococcus faecalis

10.1016/j.mayocp.2020.06.056

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Citations (24)

Fibroelastoma en el ventrículo izquierdo: un hallazgo muy poco frecuente

Revista de ecocardiografía práctica y otras técnicas de imagen cardíaca (2021)

Laura Alvarez Roy Isabel Ruíz Zamora Guillermo Pinillos Francia Pilar Portero Pérez Omer Leal Fernández

La valoración de las masas cardíacas es un problema clínico relativamente frecuente para las técnicas de imagen cardíca. Presentamos el caso de una masa cardíaca con localización inusual en el que las técnicas de imagen permitieron orientar el diagnóstico, que como no puede ser de otro modo, se confirmó en la cirugía.

10.37615/retic.v4n3a9

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Citations (0)

Assessment of left ventricular parameters in orthotopic heart transplant recipients using dual-source CT and contrast-enhanced echocardiography: Comparison with MRI

European Journal of Radiology (2012)

M. Arraiza Pedro Azcárate Carlo N. De Cecco Guillermo Viteri I. Simón-Yarza

Concordance

Bland–Altman plot

Concordance correlation coefficient

Cardiac magnetic resonance

10.1016/j.ejrad.2012.04.001

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