Anahit M. Hovhannisyan

Yerevan State University

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Ela V. Minasyan

Scientific Center of Zoology and Hydroecology

Artavazd S. Poghosyan

National Academy of Sciences of Armenia

Ani S. Dadayan

Scientific Center of Zoology and Hydroecology

Slavik A. Dadayan

Scientific Center of Zoology and Hydroecology

Anna F. Mkrtchyan

Yerevan State University

Karapet R. Ghazaryan

Yerevan State University

Samvel G. Ghazaryan

Scientific Center of Zoology and Hydroecology

Ashot S. Saghyan

Yerevan State University

Anna S. Tovmasyan

Scientific Center of Zoology and Hydroecology

Victor N. Khrustalev

Peoples' Friendship University of Russia

Cooperative Institutions

National Academy of Sciences of Armenia

Yerevan State University

Scientific Center of Zoology and Hydroecology

National Polytechnic University of Armenia

A. N. Nesmeyanov Institute of Organoelement Compounds

Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry

Russian Academy of Sciences

University of Rostock

Zhejiang Sci-Tech University

Biofuel Research Team

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COMPARATIVE STUDY OF FATTY ACID COMPOSITION OF WHITE AND BLACK SESAME OILS AND DEVELOPMENT OF A RELATIVELY EFFICIENT METHOD FOR ISOLATING THE NATURAL ANTIOXIDANT SESAMOL

Proceedings of the YSU B Chemical and Biological Sciences (2022)

Ani S. Dadayan Artavazd S. Poghosyan Samvel G. Ghazaryan Ela V. Minasyan Anahit M. Hovhannisyan

The work is devoted to a comparative study of the fatty acid composition of white and black sesame oils, as well as the development of a relatively effective method for isolating the natural antioxidant sesamol. The purpose of this work was to determine the comparative indicators of the content of fatty and free organic acids in the studied oils by gas and high-performance liquid chromatography, confirm their suitability and further use. The optimal conditions for obtaining high-quality unrefined oil from sesame seeds for the food and pharmaceutical industries were determined by the method of cold pressing (pressing chamber temperature was 100℃, oil outlet temperature was ≤ 40℃). Under these conditions, the oil yield was 30% and 27%, respectively. It was shown that finished sesame seed oils contain a highly effective natural antioxidant sesamol (oxyhydroquinone methyl ester) – 0.140 mg/kg, due to which they can be stored at room conditions for more than 3 years. The extracts of squeezes of sesame oils contain valuable free organic acids: oxalic – 0.017 mg/mL, malic – 0.02 mg/mL, fumaric – 0.001 mg/mL. Based on the research, the fatty acid composition of oils was determined and a relatively effective method for the complex processing of sesame raw materials was developed to obtain a highly effective natural antioxidant sesamol.

Sesamol

Sesame oil

10.46991/pysu:b/2022.56.3.203

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Synthesis and evaluation of new mono- and binuclear salen complexes for the Cα-alkylation reaction of amino acid substrates as chiral phase transfer catalysts

Molecular Catalysis (2024)

Anahit M. Hovhannisyan Anna S. Tovmasyan Anna F. Mkrtchyan Karapet R. Ghazaryan Ela V. Minasyan

10.1016/j.mcat.2024.114618

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THE STUDY OF ANTIOXIDANT ACTIVITY OF BIOLOGICALLY ACTIVE SUBSTANCES IN THE ALCOHOL EXTRACT OF NETTLE LEAVES

Proceedings of the YSU B Chemical and Biological Sciences (2023)

Svetlana H. Apoyan Samvel M. Vardapetyan Gohar F. Mkrtchyan Anahit M. Hovhannisyan

The purpose of this research is the extraction of phenolic compounds from nettle leaves, grown in urban conditions, with different concentrations of ethanol and the study of the antioxidant properties of these extracts. Nettle (Urtica dioica) is a great source of bioactive compounds. The content of biologically active compounds in nettle leaves depends on the growing conditions of the plant. Analysis of the electronic spectra of the extract shows that all extracts contain aurones and coumarins, hydroxybenzoic acid and flavonoids. The antioxidant activity (AO) of polyphenols in alcoholic extracts of nettle was studied using the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). It was found that the total amount of biologically active substances is greatest in a 70% ethanol solution of nettle leaves, but the antioxidant activity is higher in a 95% solution. The total amount of flavonoids in the leaves of urban nettles is higher than in the leaves of the nettle grown in the meadow. Perhaps this is connected with the process of the plant’s protective mechanisms caused by air pollution in the city.

Urtica dioica

10.46991/pysu:b/2023.57.3.207

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THE INFLUENCE OF NON-PROTEIN AMINO ACIDS AND PEPTIDES ON BACTERIAL COLLAGENASE

Proceedings of the YSU B Chemical and Biological Sciences (2022)

A. S. Sargsyan Ani J. Karapetyan Liana A. Hayriyan Anahit M. Hovhannisyan Marina Melkumyan

Bacterial collagenolytic proteases have drawn increasing attention due to their essential role in the global nitrogen cycling and their virulent role in some diseases. The inhibition of these enzymes is attractive, as it does not attack the pathogen directly but rather blocks the colonization and infiltration of the host by the clostridia. Optically active non-protein α-amino acids have been screened for their ability to inhibit collagenase of Clostridium histolyticum. Both structure-based drug design approach (modeling) and that of determining enzyme activity in the presence of amino acids have been used to identify low molecular weight inhibitors of collagenase. The compounds able to inhibit collagenase activity have been revealed and IC50 values have been estimated.

Clostridia

Microbial collagenase

10.46991/pysu:b/2022.56.2.126

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Synthesis of enantiomerically enriched β-substituted analogs of (S)-α-alanine containing 1-phenyl-1H-1,2,3-triazole groups

Amino Acids (2024)

Artavazd S. Poghosyan E. A. Khachatryan Anna F. Mkrtchyan Volodya Mirzoyan Anahit M. Hovhannisyan

A synthesis of new enantiomerically enriched derivatives of (S)-α-aminopropionic acid, containing in the β-position 1,2,3-triazole groups coupled with a o-, m- and p-substituted phenyl residue, was developed based on Cu(I) catalyzed [3 + 2] cycloaddition of azides with alkynes. As the starting materials was used the square-planar Ni(II)complex of the Schiff base of propargylglycine with the chiral auxiliary BPB (Benzylprolylbenzophenone) and 1,4-substituted phenyl azides. The assignment of the (S)-absolute configuration of the α-carbon atom of the amino acid residue of the main diastereomeric complexes of the cycloaddition products was carried out on the basis of positive Cotton effects in the region of 480–580 nm of the circular dichroism spectra. The target amino acids were isolated from acid hydrolysates of diastereomeric complexes using ion-exchange demineralization and crystallization from aqueous ethanol. Additional confirmation of the absolute configuration and determination of the enantiomeric purity of the target amino acids were carried out by chiral HPLC analysis. As a result, seven new non-proteinogenic (S)-α-amino acids, containing in the β-position a 1,2,3-triazole moiety, were synthesized.

Diastereomer

Moiety

Absolute Configuration

Asymmetric carbon

10.1007/s00726-024-03430-5

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COMPARATIVE STUDY OF THE CONTENT OF ANTHOCYANINS IN THE FRUITS OF BLUEBERRIES, BLACKBERRIES AND BLACKCURRANTS. DEVELOPMENT OF A TECHNOLOGICAL METHOD FOR OBTAINING PARTIALLY PURIFIED NEW-GALENIC EXTRACTS

Proceedings of the YSU B Chemical and Biological Sciences (2023)

Ani S. Dadayan Artavazd S. Poghosyan Samvel G. Ghazaryan Anahit M. Hovhannisyan Melanya S. Ghazaryan

The work is devoted to a comparative study of the content of anthocyanins in the fruits of blueberries, blackberries and blackcurrants to develop a technological method for producing partially purified extracts. The latter, due to the significant content of anthocyanins, compounds with antioxidant, antiaggregate, angioprotective, anti-inflammatory activities stipulate their use in the complex therapy of ophthalmic diseases (myopia, age-related macular degeneration, diabetic retinopathy). The objects of the study were fresh natural fruits of common blueberries (Vaccinium myrtillus L.), blackberries (Rubus caesius L.) and blackcurrants (Ribes nigrum L.) collected in the foothill landscapes of the city of Aparan of the Republic of Armenia, harvested in 2022. The purpose of this study was to determine the comparative indicators of the quality and content of anthocyanins in fresh fruit extracts by direct spectrometry and obtain environmentally friendly extracts with the lowest content of macro- (Fe, Cu, Zn, Ca, Mg, etc.) and microelements (Mn, Co, Cd, V, Se, Cr, As, Pb, etc.) by ion-exchange sorption and desorption. It has been shown that the highest content of the total amount of anthocyanins in terms of cyanidin-3-O-glycoside is determined in the juice of fresh blueberries in an acidic medium at an analytical wavelength of 546 nm – 4.21 ± 0.18%. At the same time, the completeness of extraction of anthocyanins (≥ 95%) from blueberries is achieved at a ratio of raw material to extractant (95% EtOH, 1% HCl) 1 : 50 and when heated in a boiling water bath for 40 min. It has been shown that the content of these macro- and microelements in the extracts after ion-exchange sorption and desorption with Ku-2×8 (H+) cation exchanger does not exceed the permissible limits.

Vaccinium myrtillus

Bilberry

Anthocyanidins

Rubus

10.46991/pysu:b/2023.57.2.100

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CCDC 612972: Experimental Crystal Structure Determination

The Cambridge Structural Database (2007)

A. S. Saghiyan L. L. Manasyan Arpine V. Geolchanyan Anahit M. Hovhannisyan Tariel V. Ghochikyan

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccnkv9b

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Synthesis and Evaluation of New Mono- and Binuclear Salen Complexes for the Cα-Alkylation Reaction of Amino Acid Substrates as Chiral Phase Transfer Catalysts

Giovanni N. Roviello Anahit M. Hovhannisyan Anna S. Tovmasyan Anna F. Mkrtchyan Karapet R. Ghazaryan

Metal salen complexes

10.2139/ssrn.4862113

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QUANTITATIVE DETERMINATION OF TANNIN IN NETTLE BY SPECTROPHOTOMETRIC AND CHROMATOGRAPHIC METHODS

Proceedings of the YSU B Chemical and Biological Sciences (2021)

Svetlana H. Apoyan Samvel M. Vardapetyan Anahit M. Hovhannisyan Gohar F. Mkrtchyan

The amount of tannins in the leaves of stinging nettle was determined depending on the phenological phase (budding phase, mass flowering phase and fruiting phase). UV spectrophotometric and high performance liquid chromatographic (HPLC) methods were used to quantify tannins in the plant. It was found that the maximum accumulation of this group of substances in nettle leaves occurs in the fruiting phase. Based on the results of the study, the chromatographic method is optimal for the analysis of tannins in nettle leaves.

Tannin

Condensed tannin

10.46991/pysu:b/2021.55.1.012

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Asymmetric synthesis of anti-diastereoisomers of β-heterocycle substituted (S)-α-aminobutyric acids

Tetrahedron Asymmetry (2006)

A. S. Saghiyan L. L. Manasyan Arpine V. Geolchanyan Anahit M. Hovhannisyan Tariel V. Ghochikyan

Diastereomer

10.1016/j.tetasy.2006.10.016

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Citations (11)