Journal Article The effect of electroconvulsive shock at a clinically equivalent schedule on rat cortical β-adrenoceptors Get access R H Belmaker, R H Belmaker Jerusalem Mental Health Center—Ezrath Nashim, P.O.B. 140, Jerusalem, Israel Jerusalem Mental Health Center—Ezrath Nashim, P.O.B. 140, Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar B Lerer, B Lerer Jerusalem Mental Health Center—Ezrath Nashim, P.O.B. 140, Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar J Bannet, J Bannet Jerusalem Mental Health Center—Ezrath Nashim, P.O.B. 140, Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar B Birmaher B Birmaher Jerusalem Mental Health Center—Ezrath Nashim, P.O.B. 140, Jerusalem, Israel Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 34, Issue 4, April 1982, Page 275, https://doi.org/10.1111/j.2042-7158.1982.tb04246.x Published: 12 April 2011 Article history Received: 07 September 1981 Published: 12 April 2011
Increased ^3 H-spiperone binding after chronic neuroleptic treatment has been proposed as a molecular model of tardive dyskinesia. Sulpiride has been claimed to be an atypical neuroleptic that might not produce tardive dyskinesia. The effect of chronic sulpiride was, therefore, compared to that of chronic haloperidol on striatal ^3 H-spiperone binding. 3 weeks of haloperidol feeding caused a 28% increase in ^3 H-spiperone binding, whereas even very high dose sulpiride had no effect on spiperone binding. These findings support the concept that sulpiride may be a unique neuroleptic with regard to long-term effects on dopamine receptors.
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