Andranovich Sv

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Mazo Eb

Gamidov Si

РИ

Р И Овчинников

Institut de Médecine de la Reproduction

Iremashvili Vv

Cooperative Institutions

Institut de Médecine de la Reproduction

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation

Sechenov University

Saratov State Medical University

Ministry of Health of the Russian Federation

Peoples' Friendship University of Russia

"National Medical Research Center for Rehabilitation and Balneology" of the Ministry of Health of the Russian Federation

Moscow State University

Lomonosov Moscow State University

Moscow State University of Medicine and Dentistry

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[Postcompression test in diagnosis of vasculogenic erectile dysfunction].

PubMed (2005)

Mazo Eb Gamidov Si Р И Овчинников Andranovich Sv Iremashvili Vv

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[Comparative assessment of the results of ultrasonic measurements of postocclusive alterations in the brachial and cavernous arteries].

PubMed (2007)

Mazo Eb Gamidov Si Р И Овчинников Andranovich Sv Iremashvili Vv

We compared the results of functional endothelial tests of the cavernous penile arteries by the modified by us method with results of the study of endothelial function of the brachial artery. The analysis of the results of examination of 116 patients with endothelial dysfunction of various genesis and 14 men free of endothelial dysfunction has not found a correlation between the tests, but all the patients with postocclusive increase in the diameter of the cavernous artery by less than 50% indicating arteriogenic endothelial dysfunction had signs of endothelial dysfunctions in the study of brachial artery. This suggests the presence of systemic endothelial dysfunction in all the examinees with arteriogenic endothelial dysfunction supporting its role in pathogenesis of this form of endothelial dysfunction.

Endothelial Dysfunction

Brachial artery

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Prediction of clinical efficacy of levitra (vardenafil) in patients with arteriogenic erectile dysfunction

Urologii︠a︡ (Russia) (2006)

Gamidov Si Mazo Eb Р И Овчинников Andranovich Sv Iremashvili Vv

Oral inhibitors of phosphodiesterase of type 5 (PDE-5) are drugs of choice in therapy of erectile dysfunction (ED). However, 20-30% patients do not respond to them. We studied potentialities of ultrasonic investigation (UI) of postcompression increase in cavernous arteries diameter (PICAD) after intake of vardenafil (levitra, Bayer&GlaxoSmithKline) which is a PDE-5 inhibitor in prediction of clinical efficacy of this medicine. A total of 75 males with ED participated in the study. Significant correlations were found between PICAD after vardenafil administration and clinical efficacy of the drug in patients with arteriogenic ED. The highest response to the drug was observed at PICAD value > or = 50%. High sensitivity and specificity of the PICAD threshold value obtained indicate high potentialities of the method in decision making on treatment policy in patients with organic ED.

Vardenafil

Clinical efficacy

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