Hui Sun

Wuhan University

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Yi Liang

Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences

Shuai Jiang

Pingdingshan University

Yanxia Jin

Second Hospital of Shandong University

Xiangdong Ye

Hubei University of Medicine

Yalin Yin

Xiamen Tobacco Industry (China)

Wenhui Yu

China Pharmaceutical University

Guojun Yu

Cancer Genetics (United States)

Yanting Su

Hubei University of Science and Technology

Yu Zhou

Guizhou Provincial People's Hospital

Barry Hon Cheung Wong

Wuhan University

Cooperative Institutions

Wuhan University

Chinese Academy of Sciences

Sun Yat-sen University

Huazhong University of Science and Technology

Chinese Academy of Medical Sciences & Peking Union Medical College

Tianjin Medical University

Nanjing Medical University

Tianjin Medical University Cancer Institute and Hospital

Fudan University

University of Chinese Academy of Sciences

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Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

Cell (2013)

Yuanchao Xue Kunfu Ouyang Jie Huang Yu Zhou Hong Ouyang

Reprogramming

Polypyrimidine tract-binding protein

Transcription

10.1016/j.cell.2012.11.045

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Citations (524)

A Lever Coupling Mechanism in Dual-Mass Micro-Gyroscopes for Improving the Shock Resistance along the Driving Direction

Sensors (2017)

Yang Gao Hongsheng Li Libin Huang Hui Sun

This paper presents the design and application of a lever coupling mechanism to improve the shock resistance of a dual-mass silicon micro-gyroscope with drive mode coupled along the driving direction without sacrificing the mechanical sensitivity. Firstly, the mechanical sensitivity and the shock response of the micro-gyroscope are theoretically analyzed. In the mechanical design, a novel lever coupling mechanism is proposed to change the modal order and to improve the frequency separation. The micro-gyroscope with the lever coupling mechanism optimizes the drive mode order, increasing the in-phase mode frequency to be much larger than the anti-phase one. Shock analysis results show that the micro-gyroscope structure with the designed lever coupling mechanism can notably reduce the magnitudes of the shock response and cut down the stress produced in the shock process compared with the traditional elastic coupled one. Simulations reveal that the shock resistance along the drive direction is greatly increased. Consequently, the lever coupling mechanism can change the gyroscope's modal order and improve the frequency separation by structurally offering a higher stiffness difference ratio. The shock resistance along the driving direction is tremendously enhanced without loss of the mechanical sensitivity.

Lever

Shock response spectrum

10.3390/s17050995

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Citations (9)

Galectin-7 promotes cisplatin efficacy by facilitating apoptosis and G3BP1 degradation in cervical cancer

Biochemical Pharmacology (2023)

Chenglong Liu Limin Zhou Jia Chen Zelan Yang Shan Chen

Stress granule

Galectin-1

10.1016/j.bcp.2023.115834

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Citations (7)

Identification of a type II LacNAc specific binding lectin CMRBL from Cordyceps militaris

International Journal of Biological Macromolecules (2023)

Xiaomei Liu Zelan Yang Chenglong Liu Bo Xu Xueqing Wang

Ricin

C-type lectin

CD69

10.1016/j.ijbiomac.2023.123207

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Citations (2)

Peropsin Effects Light-dependent Modulation of Retinyl Esters in the RPE

Investigative Ophthalmology & Visual Science (2016)

Jeremy D. Cook Eunice Sze Yin Ng Marcia Lloyd Shannan Eddington Dean Bok

Modulation (music)

Source

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Structural Basis of Specific Recognition of Non-Reducing Terminal N-Acetylglucosamine by an Agrocybe aegerita Lectin

PLoS ONE (2015)

Xiao‐Ming Ren De‐Feng Li Shuai Jiang Xianqing Lan Yonglin Hu

O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a reversible post-translational modification that plays essential roles in many cellular pathways. Research in this field, however, is hampered by the lack of suitable probes to identify, accumulate, and purify the O-GlcNAcylated proteins. We have previously reported the identification of a lectin from the mushroom Agrocybe aegerita, i.e., Agrocybe aegerita lectin 2, or AAL2, that could bind terminal N-acetylglucosamine with higher affinities and specificity than other currently used probes. In this paper, we report the crystal structures of AAL2 and its complexes with GlcNAc and GlcNAcβ1-3Galβ1-4GlcNAc and reveal the structural basis of GlcNAc recognition by AAL2 and residues essential for the binding of terminal N-acetylglucosamine. Study on AAL2 may enable us to design a protein probe that can be used to identify and purify O-GlcNAcylated proteins more efficiently.

N-Acetylglucosamine

Acetylglucosamine

10.1371/journal.pone.0129608

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Citations (17)

A Lectin with Mycelia Differentiation and Antiphytovirus Activities from the Edible Mushroom Agrocybe aegerita

BMB Reports (2003)

Hui Sun Zhao Chen Xin Tong Yi Qi

A lectin named AAL has been purified from the fruiting bodies of the edible mushroom Agrocybe aegerita. AAL consisted of two identical subunits of 15.8 kDa, its pI was about 3.8 determined by isoelectric focusing, and no carbohydrate was discerned. Being treated by pyrogultamate aminopeptidase, the blocked N-terminus of AAL was sequenced as QGVNIYNI. AAL agglutinated human and animal erythrocytes regardless of blood type or animal species. Its hemagglutinating activity was unaffected by acid or alkali treatment and demetalization or addition of divalent metals Mg(2+), Ca(2+) and Zn(2+). AAL was toxic to mice: its LD50 was 15.85 mg per kilogram body weight by intraperitoneal injection. In this study, two novel activities of AAL were proved. It showed inhibition activity to infection of tobacco mosaic virus on Nicotiana glutinosa. The result of IEF suggested that AAL attached to TMV particles. Mycelia differentiation promotion was the other interesting activity. AAL promoted the differentiation of fruit body primordia from the mycelia of Agrocybe aegerita and Auricularia polytricha. AAL antiserum was prepared and immunologically cross-reactived with several proteins from five other kinds of mushrooms. These results suggested that AAL probably was a representative of a large protein family, which plays important physiological roles in mushroom.

Edible mushroom

Antiviral protein

10.5483/bmbrep.2003.36.2.214

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Citations (61)

Expression characteristics of annexin A2 in dermal papilla cells with aggregative behavior

Chinese Journal of Dermatology (2015)

Rushan Xia Hui Sun Shiqin Tao Lei Cao

Objective To analyze the expression characteristics of annexin A2 in dermal papilla cells (DPCs) with aggregative behavior. Methods Reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot were performed to measure the mRNA and protein expressions of annexin A2 respectively in DPCs with or without aggregative behavior. Results The mRNA expression level of annexin A2 was significantly higher in DPCs with aggregative behavior than in those without aggregative behavior (0.50 ± 0.15 vs. 0.35 ± 0.19, t= 8.26, P< 0.05). Western blot showed that annexin A2 had two isoforms, including one isoform with a relative molecular mass of 40 000 and the other one with a relative molecular mass of 36 000. The annexin A2 isoform with a relative molecular mass of 40 000 was highly expressed in both DPCs with aggregative behavior and those without aggregative behavior, while the other isoform was only expressed in DPCs with aggregative behavior. Conclusion Annexin A2 may be closely related to the aggregative growth of DPCs. Key words: Hair follicle; Annexin A2; Cell growth processes; Reverse transcriptase polymerase chain reaction; Blotting, Western; Dermal papilla cells

Annexin A2

Dermal papillae

Northern blot

Dental papilla

10.3760/cma.j.issn.0412-4030.2015.10.013

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Surgical treatment of uremia caused secondary hyperparathyroidism

国际外科学杂志 (2010)

Zhang Chun-hai Xuehai Bian Guang Zhang Hui Sun

Uremia caused secondary hyperparathyroidism is one of the common and serious complications caused by uremia. Surgery treatment is effective. Total parathyroidectomy plus forearm transplantation is more commonly used because of exact outcomes and easy monitoring. It is necessary to be fully prepared be-fore operation,particularly to clarify the location of parathyroid gland. Yet each surgical method has its re-lapse rate. Key words: Uremia; Secondary hyperparathyroidism

Uremia

Parathyroid gland

10.3760/cma.j.issn.1673-4203.2010.01.020

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sLe<sup>x</sup> expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator

Cancer Biology and Medicine (2021)

Yawen Song Hui Sun Kailiang Wu Jianke Lyu Jingyue Zhang

Objective: Mucin 1 (MUC1/EMA) and sialyl Lewis X (sLex) indicate polarity reversal in invasive micropapillary carcinoma (IMPC).The purpose of this study was to evaluate the expression of MUC1/EMA and sLex and to assess their diagnostic and prognostic valuein patients with IMPC. Methods: The expression of sLex and MUC1/EMA in 100 patients with IMPC and a control group of 89 patients with invasive ductalcarcinoma not otherwise specified (IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPCor IDC-NOS for primary culture and immunofluorescence analysis. Results: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to expressmore sLex and MUC1/EMA in the cytomembranes (the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells.In IMPC, high cytomembrane expression of sLex, but not MUC1/EMA, indicated poor prognosis. In addition, among the 100patients with IMPC, 10 patients had sLex+/EMA- expression patterns, and 8 patients had sLex-/EMA+ expression patterns. Theprimary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells.Immunofluorescence analysis showed that MUC1/EMA and sLex were co-expressed on the cytomembranes in IMPC cell clusters andin the cytoplasm in IDC-NOS cells. Conclusions: sLex can be used as a prognostic indicator and can be combined with MUC1/EMA as a complementary diagnosticindicator to avoid missed IMPC diagnosis.

MUC1

Immunofluorescence

Sialyl-Lewis X

10.20892/j.issn.2095-3941.2020.0422

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Citations (9)